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Category:GO:0047747 ! cholate-CoA ligase activity
name: cholate-CoA ligase activity
namespace: molecular_function
alt_id: GO:0047477
def: "Catalysis of the reactions: (1) ATP + cholate + CoA = AMP + diphosphate + choloyl-CoA and (2) ATP + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA = AMP + diphosphate + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA. This reaction is the first step in the conjugation of bile acids with amino acids, converting bile acids into their acyl-CoA thioesters. Chenodeoxycholate, deoxycholate, lithocholate and trihydroxycoprostanoate can also act as substrates." [EC:6.2.1.7]
synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate--CoA ligase activity" RELATED [EC:6.2.1.7]
synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate-CoA ligase activity" EXACT []
synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate:CoA ligase (AMP-forming) activity" RELATED [EC:6.2.1.7]
synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoate-CoA ligase activity" RELATED [EC:6.2.1.7]
synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoate-CoA synthetase activity" RELATED [EC:6.2.1.7]
synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl coenzyme A synthetase activity" RELATED [EC:6.2.1.7]
synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate-CoA ligase activity" RELATED [EC:6.2.1.7]
synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate:CoA ligase (AMP-forming)" RELATED [EC:6.2.1.7]
synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA ligase activity" RELATED [EC:6.2.1.7]
synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA synthetase activity" RELATED [EC:6.2.1.7]
synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl coenzyme A synthetase activity" RELATED [EC:6.2.1.7]
synonym: "BAL activity" RELATED [EC:6.2.1.7]
synonym: "bile acid CoA ligase activity" RELATED [EC:6.2.1.7]
synonym: "bile acid coenzyme A ligase activity" RELATED [EC:6.2.1.7]
synonym: "cholate thiokinase activity" RELATED [EC:6.2.1.7]
synonym: "cholate:CoA ligase (AMP-forming)" RELATED [EC:6.2.1.7]
synonym: "cholic acid:CoA ligase activity" RELATED [EC:6.2.1.7]
synonym: "cholic thiokinase activity" RELATED [EC:6.2.1.7]
synonym: "choloyl coenzyme A synthetase activity" RELATED [EC:6.2.1.7]
synonym: "choloyl-CoA synthetase activity" RELATED [EC:6.2.1.7]
synonym: "cholyl-CoA synthetase activity" RELATED [EC:6.2.1.7]
synonym: "THCA-CoA ligase activity" RELATED [EC:6.2.1.7]
synonym: "trihydroxycoprostanoyl-CoA synthetase activity" RELATED [EC:6.2.1.7]
xref: EC:6.2.1.7
xref: MetaCyc:CHOLATE--COA-LIGASE-RXN
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity
AmiGO
<GOterm>GO:0047747</GOterm>
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