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Category:GO:0035539 ! 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
name: 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate (8-oxo-dGTP) + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate (8-oxo-dGMP) + diphosphate. 8-oxo-dGTP is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA." [PMID:17804481, PMID:7782328, PMID:7859359, RHEA:31575]
synonym: "8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase activity" EXACT [PMID:17804481]
synonym: "8-oxo-7,8-dihydro-deoxyguanosine triphosphate pyrophosphatase activity" EXACT [PMID:17804481]
synonym: "8-oxo-7,8-dihydrodeoxyguanosine triphosphatase activity" EXACT [PMID:7782328]
synonym: "8-oxo-dGTP pyrophosphohydrolase activity" EXACT [PMID:17804481]
synonym: "8-oxo-dGTPase activity" EXACT [PMID:7782328]
xref: EC:3.6.1.55
xref: RHEA:31575
is_a: GO:0047429 ! nucleoside triphosphate diphosphatase activity
AmiGO
<GOterm>GO:0035539</GOterm>
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