Category:GO:0034038 ! deoxyhypusine synthase activity

name: deoxyhypusine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine. Four sub-reactions have been identified,in which the intermediates remain tightly associated with the enzyme: spermidine + NAD+ = dehydrospermidine + NADH; dehydrospermidine + [enzyme]-lysine = N-(4-aminobutylidene)-[enzyme]-lysine + propane-1,3-diamine; N-(4-aminobutylidene)-[enzyme]-lysine + [eIF5A-precursor]-lysine = N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + [enzyme]-lysine; N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + NADH + H+ = [eIF5A-precursor]-deoxyhypusine + NAD+." [GOC:pde, RHEA:33299]
comment: Note that this term is equivalent to the obsolete molecular function term 'deoxyhypusine synthase activity ; GO:0004171' and corresponds closely to the biological process term 'deoxyhypusine biosynthetic process from spermidine, using deoxyhypusine synthase ; GO:0050983'.
synonym: "(4-aminobutyl)lysine synthase" BROAD [EC:2.5.1.46]
synonym: "eIF-5A-deoxyhypusine synthase activity" RELATED [EC:2.5.1.46]
synonym: "spermidine dehydrogenase" BROAD [EC:2.5.1.46]
xref: EC:2.5.1.46
xref: MetaCyc:2.5.1.46-RXN
xref: RHEA:33299
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

AmiGO <GOterm>GO:0034038</GOterm>
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