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Category:GO:0033783 ! 25-hydroxycholesterol 7-alpha-hydroxylase activity
name: 25-hydroxycholesterol 7-alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reactions: 25-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha,25-dihydroxycholesterol + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. Also converts (25R)-cholest-5-ene-3beta,26-diol to (25R)-cholest-5-en-3beta,7alpha,26-triol." [EC:1.14.14.29]
synonym: "25-hydroxycholesterol 7alpha-monooxygenase activity" RELATED [EC:1.14.14.29]
synonym: "cholest-5-ene-3beta,25-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating) activity" RELATED [EC:1.14.14.29]
synonym: "CYP7B1" RELATED [EC:1.14.14.29]
synonym: "CYP7B1 oxysterol 7alpha-hydroxylase activity" RELATED [EC:1.14.14.29]
xref: EC:1.14.14.29
is_a: GO:0008387 ! steroid 7-alpha-hydroxylase activity
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
AmiGO
<GOterm>GO:0033783</GOterm>
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