Category:GO:0030374 ! obsolete nuclear receptor coactivator activity

This GO term has been obsoleted. Do not annotate to it.

id: GO:0030374
name: obsolete nuclear receptor coactivator activity
namespace: molecular_function
alt_id: GO:0038049
def: "OBSOLETE. A transcription coactivator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:dph, GOC:tb]
comment: The reason for obsoletion is that these activities are not necessarily specific for nuclear receptors subclass of dbTFs, so that distinction leads to misannotations.
synonym: "ligand-activated RNA polymerase II transcription factor binding transcription factor activity" EXACT []
synonym: "ligand-dependent nuclear receptor transcription co-activator activity" EXACT []
synonym: "ligand-dependent nuclear receptor transcription coactivator activity" EXACT []
synonym: "nuclear receptor transcription coactivator activity" EXACT []
synonym: "transcription factor activity, ligand-activated RNA polymerase II transcription factor binding" EXACT []
is_obsolete: true
replaced_by: GO:0003713 ! transcription coactivator activity

AmiGO <GOterm>GO:0030374</GOterm>
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