name: nuclear receptor coactivator activity
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def: "A transcription coactivator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:dph, GOC:tb]
comment: For usage guidance, see comment in GO:0003712 ; transcription coregulator activity.
synonym: "ligand-activated RNA polymerase II transcription factor binding transcription factor activity" EXACT 
synonym: "ligand-dependent nuclear receptor transcription co-activator activity" EXACT 
synonym: "ligand-dependent nuclear receptor transcription coactivator activity" EXACT 
synonym: "nuclear receptor transcription coactivator activity" EXACT 
synonym: "transcription factor activity, ligand-activated RNA polymerase II transcription factor binding" EXACT 
is_a: GO:0003713 ! transcription coactivator activity
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Pages in category "GO:0030374 ! nuclear receptor coactivator activity"
The following 3 pages are in this category, out of 3 total.