It is now the 5th OPEN Period for CACAO Fall 2017! It will end on Sunday November 19, 2017 at 11:59 pm CST
This is your chance to make annotations OR challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.

Have any questions? Please email us at

Category:GO:0019172 ! glyoxalase III activity

Jump to: navigation, search
DAG for GO:0019172id: GO:0019172

name: glyoxalase III activity
namespace: molecular_function
def: "Catalysis of the reaction: methylglyoxal + H2O = D-lactate." [EC:, GOC:mcc,, MetaCyc:GLYOXIII-RXN, PMID:21696459, PMID:7848303, RHEA:27757]
comment: Note that this term was reinstated from obsolete. Also note that this enzymatic activity converts methylglyoxal to D-lactate in a single glutathione (GSH)-independent step. The other known route for this conversion is the two-step GSH-dependent pathway catalyzed by EC (lactoylglutathione lyase) and EC (hydroxyacylglutathione hydrolase).
synonym: "(R)-lactate hydro-lyase" EXACT []
synonym: "D-lactate dehydratase" EXACT []
synonym: "glutathione-independent glyoxalase activity" RELATED []
xref: MetaCyc:GLYOXIII-RXN
xref: RHEA:27754
is_a: GO:0016836 ! hydro-lyase activity
relationship: part_of: GO:0019249 ! lactate biosynthetic process
relationship: part_of: GO:0061727 ! methylglyoxal catabolic process to lactate


Last version checked

23:02:2017 10:01.

Last updated

Gene Ontology Home
The contents of this box are automatically generated. You can help by adding information to the "Notes"

Usage Notes


See Help:References for how to manage references in GONUTS.

Pages in category "GO:0019172 ! glyoxalase III activity"

The following 4 pages are in this category, out of 4 total.

Jump to pages starting with: H M P R