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Category:GO:0019172 ! glyoxalase III activity
name: glyoxalase III activity
namespace: molecular_function
def: "Catalysis of the reaction: methylglyoxal + H2O = D-lactate." [GOC:mcc, PMID:21696459, PMID:7848303, RHEA:27754]
comment: Note that this term was reinstated from obsolete. Also note that this enzymatic activity converts methylglyoxal to D-lactate in a single glutathione (GSH)-independent step. The other known route for this conversion is the two-step GSH-dependent pathway catalyzed by EC:4.4.1.5 (lactoylglutathione lyase) and EC:3.1.2.6 (hydroxyacylglutathione hydrolase).
synonym: "(R)-lactate hydro-lyase" EXACT []
synonym: "D-lactate dehydratase" EXACT []
synonym: "glutathione-independent glyoxalase activity" RELATED []
xref: EC:4.2.1.130
xref: MetaCyc:GLYOXIII-RXN
xref: RHEA:27754
is_a: GO:0016836 ! hydro-lyase activity
relationship: part_of: GO:0019249 ! lactate biosynthetic process
relationship: part_of: GO:0061727 ! methylglyoxal catabolic process to lactate
AmiGO
<GOterm>GO:0019172</GOterm>
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