GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
Category:GO:0017059 ! serine palmitoyltransferase complex
name: serine palmitoyltransferase complex
namespace: cellular_component
def: "A protein complex that catalyses the condensation of L-serine with palmitoyl-CoA to form 3-ketosphinganine, the sphingoid base which is the starting point for all sphingolipids. In bacteria the enzyme is a cytoplasmic homodimer, whereas in eukaryotes the enzyme is a multiprotein complex localised to the endoplasmic reticulum. The eukaryotic complex consists of catalytic components (SPTLC1, SPTLC2 and SPTLC3 in humans; LCB1 and LCB2 in S. cerevisiae) and regulatory components, which include activators (SPTSSA/SPTSSB in humans, TSC3 in S. cerevisiae) and negative regulators (ORMDL1/ORMDL2/ORMDL3 in humans, ORM1/2 in S. cerevisiae )." [PMID:29863195, PMID:33558761]
synonym: "serine C-palmitoyltransferase complex" RELATED []
synonym: "serine palmitoyltransferase, Orm1/2, Tsc3 and Sac1 complex" RELATED []
synonym: "SPOTS complex" RELATED []
synonym: "SPT" RELATED []
is_a: GO:0002178 ! palmitoyltransferase complex
AmiGO
<GOterm>GO:0017059</GOterm>
Gene Ontology Home
The contents of this box are automatically generated. You can help by adding information to the "Notes"
Usage Notes
References
See Help:References for how to manage references in GONUTS.
This category currently contains no pages or media.
