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Category:GO:0008118 ! N-acetyllactosaminide alpha-2,3-sialyltransferase activity
name: N-acetyllactosaminide alpha-2,3-sialyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H+." [PMID:10206952, RHEA:52316]
comment: The substrate for this reaction is a beta-D-galactosyl-(1->4)-N-acetyl- D-glucosaminyl (known as type 2 histo-blood group precursor disaccharide) in non-reducing termini of glycan moieties in glycoproteins and glycolipids.
synonym: "alpha2->3 sialyltransferase activity" RELATED [EC:2.4.3.6]
synonym: "cytidine monophosphoacetylneuraminate-beta-galactosyl(1->4)acetylglucosaminide alpha2->3-sialyltransferase activity" RELATED [EC:2.4.3.6]
synonym: "N-acetyllactosaminide alpha-2,3-sialyltransferase" EXACT [EC:2.4.3.6]
synonym: "neolactotetraosylceramide alpha-2,3-sialyltransferase activity" NARROW [EC:2.4.3.6]
xref: EC:2.4.3.6
xref: MetaCyc:2.4.99.6-RXN
xref: RHEA:52316
is_a: GO:0008373 ! sialyltransferase activity
AmiGO
<GOterm>GO:0008118</GOterm>
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