Category:GO:0004879 ! ligand-dependent nuclear receptor activity

name: ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
namespace: molecular_function
def: "Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling, GOC:txnOH]
comment: GO:0004879 is intended for annotation of nuclear receptors that regulate transcription by binding directly to DNA. When the nuclear receptor functions by binding to other transcription factors or transcription factor complexes, consider instead annotating to 'ligand-activated RNA polymerase II transcription factor binding transcription factor activity ; GO:0038049'.
synonym: "ligand-dependent nuclear receptor activity" RELATED [GOC:bf]
synonym: "ligand-dependent transcription factor activity" RELATED [GOC:bf]
synonym: "nuclear hormone receptor" NARROW []
synonym: "nuclear receptor activity" RELATED [GOC:bf]
is_a: GO:0000981 ! sequence-specific DNA binding RNA polymerase II transcription factor activity
is_a: GO:0038023 ! signaling receptor activity

AmiGO <GOterm>GO:0004879</GOterm>
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