Category:GO:0004662 ! CAAX-protein geranylgeranyltransferase activity

name: CAAX-protein geranylgeranyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families." [EC:2.5.1.59, PMID:8621375]
synonym: "geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity" EXACT []
synonym: "geranylgeranyltransferase type I activity" EXACT []
synonym: "GGTase-I activity" EXACT []
synonym: "GGTaseI activity" EXACT []
synonym: "protein geranylgeranyltransferase type I" RELATED [EC:2.5.1.59]
synonym: "type I protein geranyl-geranyltransferase activity" RELATED [EC:2.5.1.59]
xref: EC:2.5.1.59
xref: MetaCyc:RXN-3701
is_a: GO:0004661 ! protein geranylgeranyltransferase activity

AmiGO <GOterm>GO:0004662</GOterm>
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