CVMJH:R1A

Species (Taxon ID)	Murine coronavirus (strain JHM) (MHV-JHM) (Murine hepatitis virus). (11144)
Gene Name(s)	No Information Provided.
Protein Name(s)	Replicase polyprotein 1a pp1a ORF1a polyprotein Non-structural protein 1 nsp1 p28 Non-structural protein 2 nsp2 p65 Non-structural protein 3 nsp3 PL1-PRO/PL2-PRO PL1/PL2 Papain-like proteinases 1/2 p210 Non-structural protein 4 nsp4 Peptide HD2 p44 3C-like proteinase 3CL-PRO 3CLp M-PRO nsp5 p27 Non-structural protein 6 nsp6 Non-structural protein 7 nsp7 p10 Non-structural protein 8 nsp8 p22 Non-structural protein 9 nsp9 p12 Non-structural protein 10 nsp10 Growth factor-like peptide GFL p15 Non-structural protein 11 nsp11
External Links
UniProt	P0C6V1
EMBL	M55148 M18040 S51684
PIR	A36815 B36815
RefSeq	YP_209230.1
ProteinModelPortal	P0C6V1
SMR	P0C6V1
Proteomes	UP000007193
GO	GO:0033644 GO:0044220 GO:0016021 GO:0004197 GO:0008242 GO:0003723 GO:0003968 GO:0008270 GO:0039595 GO:0039520 GO:0039648 GO:0039548 GO:0039579 GO:0039502 GO:0019079 GO:0019082
InterPro	IPR022570 IPR002589 IPR014828 IPR014829 IPR014822 IPR002705 IPR008740 IPR013016 IPR018995 IPR029063 IPR009003 IPR014827
Pfam	PF11963 PF01661 PF09401 PF08716 PF08717 PF08710 PF01831 PF05409 PF08715
SMART	SM00506
SUPFAM	SSF101816 SSF144246 SSF50494 SSF53335
PROSITE	PS51442 PS51154 PS51124

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0004197	cysteine-type endopeptidase activity	PMID:10933699	ECO:0000315			F		Figure 6. Compares the phenotypes of the wild type PLP2 peptide and PLP2 peptides after having undergone site-directed mutagenesis which replaced the cysteine residue necessary for cleavage. The figure shows a loss of the cysteine results in PLP2 no longer being capable of properly cleaving its substrate Cen-MP1, both of which originate from ORF1a.	complete CACAO 10350
	GO:0097264	self proteolysis	PMID:10933699	ECO:0000314			P		Figure 6. Shows the peptide is capable of undergoing self-proteolysis.	complete CACAO 10362
involved_in	GO:0097264	self proteolysis	PMID:10933699	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	PMID:10933699	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001172	transcription, RNA-templated	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003968	P		Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032592	F		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014822 InterPro:IPR018995 InterPro:IPR036333	F		Seeded From UniProt	complete
enables	GO:0003968	RNA-directed 5'-3' RNA polymerase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002705 InterPro:IPR013016	F		Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014827 InterPro:IPR014828 InterPro:IPR014829 InterPro:IPR037204 InterPro:IPR037230	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002705 InterPro:IPR013016	P		Seeded From UniProt	complete
enables	GO:0008234	cysteine-type peptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002705 InterPro:IPR013016	F		Seeded From UniProt	complete
enables	GO:0008242	omega peptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014827 InterPro:IPR014828 InterPro:IPR014829 InterPro:IPR037204 InterPro:IPR037230	F		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018995 InterPro:IPR036333	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014827 InterPro:IPR014828 InterPro:IPR014829 InterPro:IPR037204 InterPro:IPR037230	F		Seeded From UniProt	complete
involved_in	GO:0019079	viral genome replication	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014822 InterPro:IPR018995 InterPro:IPR036333	P		Seeded From UniProt	complete
involved_in	GO:0019082	viral protein processing	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008740	P		Seeded From UniProt	complete
enables	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.4.19.12	F		Seeded From UniProt	complete
involved_in	GO:0039548	suppression by virus of host IRF3 activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1092	P		Seeded From UniProt	complete
involved_in	GO:0039520	induction by virus of host autophagy	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1072	P		Seeded From UniProt	complete
involved_in	GO:0030683	evasion or tolerance by virus of host immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0899	P		Seeded From UniProt	complete
involved_in	GO:0039503	suppression by virus of host innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1090	P		Seeded From UniProt	complete
involved_in	GO:0039502	suppression by virus of host type I interferon-mediated signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1114	P		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0039657	suppression by virus of host gene expression	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1190	P		Seeded From UniProt	complete
involved_in	GO:0039595	induction by virus of catabolism of host mRNA	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1132	P		Seeded From UniProt	complete
involved_in	GO:0039579	suppression by virus of host ISG15 activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1095	P		Seeded From UniProt	complete
involved_in	GO:0039648	modulation by virus of host protein ubiquitination	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1130 UniProtKB-KW:KW-1127	P		Seeded From UniProt	complete
enables	GO:0008234	cysteine-type peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0788	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
part_of	GO:0030430	host cell cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1035	C		Seeded From UniProt	complete
part_of	GO:0033644	host cell membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1043 UniProtKB-SubCell:SL-0380	C		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
part_of	GO:0044220	host cell perinuclear region of cytoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0382	C		Seeded From UniProt	complete
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References

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