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CVMA5:R1A
Contents
| Species (Taxon ID) | Murine coronavirus (strain A59) (MHV-A59) (Murine hepatitis virus). (11142) | |
| Gene Name(s) | No Information Provided. | |
| Protein Name(s) | Replicase polyprotein 1a
pp1a ORF1a polyprotein Non-structural protein 1 nsp1 p28 Non-structural protein 2 nsp2 p65 Non-structural protein 3 nsp3 PL1-PRO/PL2-PRO PL1/PL2 Papain-like proteinases 1/2 p210 Non-structural protein 4 nsp4 Peptide HD2 p44 3C-like proteinase 3CL-PRO 3CLp M-PRO nsp5 p27 Non-structural protein 6 nsp6 Non-structural protein 7 nsp7 p10 Non-structural protein 8 nsp8 p22 Non-structural protein 9 nsp9 p12 Non-structural protein 10 nsp10 Growth factor-like peptide GFL p15 Non-structural protein 11 nsp11 | |
| External Links | ||
| UniProt | P0C6V0 | |
| EMBL | X73559 AF029248 M27198 | |
| PIR | A32440 S15760 | |
| RefSeq | NP_045298.1 | |
| PDB | 2M0A | |
| PDBsum | 2M0A | |
| ProteinModelPortal | P0C6V0 | |
| SMR | P0C6V0 | |
| GeneID | 1489749 | |
| Proteomes | UP000007192 | |
| GO | GO:0033644 GO:0044220 GO:0016021 GO:0004197 GO:0008242 GO:0003723 GO:0003968 GO:0008270 GO:0039595 GO:0039520 GO:0039648 GO:0039548 GO:0039579 GO:0039502 GO:0019079 GO:0019082 | |
| InterPro | IPR022570 IPR002589 IPR014828 IPR014829 IPR014822 IPR002705 IPR008740 IPR013016 IPR018995 IPR029063 IPR009003 IPR014827 | |
| Pfam | PF11963 PF01661 PF09401 PF08716 PF08717 PF08710 PF01831 PF05409 PF08715 | |
| SMART | SM00506 | |
| SUPFAM | SSF101816 SSF144246 SSF50494 SSF53335 | |
| PROSITE | PS51442 PS51154 PS51124 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0003968 |
RNA-directed RNA polymerase activity |
ECO:0000314 |
F |
Table 1. Shows the levels of RNA synthesis present in infected and uninfected cells at certain time points. DNase was added to the fractions tested, so the only template available was RNA. Showing RNA-directed RNA polymerase activity. |
complete | |||||
| GO:0097264 |
self proteolysis |
ECO:0000315 |
P |
Figure 2. Shows certain deletions result in a loss of cleavage. (Wild-type protein not shown here). |
complete | |||||
|
involved_in |
GO:0097264 |
self proteolysis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001172 |
transcription, RNA-templated |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0003968 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003676 |
nucleic acid binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003968 |
RNA-directed 5'-3' RNA polymerase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004197 |
cysteine-type endopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR014827 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008234 |
cysteine-type peptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008242 |
omega peptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR014827 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR014827 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0019079 |
viral genome replication |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019082 |
viral protein processing |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0036459 |
thiol-dependent ubiquitinyl hydrolase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0039714 |
cytoplasmic viral factory |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039548 |
suppression by virus of host IRF3 activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0033644 |
host cell membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039648 |
modulation by virus of host protein ubiquitination |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039503 |
suppression by virus of host innate immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030430 |
host cell cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030683 |
evasion or tolerance by virus of host immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039502 |
suppression by virus of host type I interferon-mediated signaling pathway |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008234 |
cysteine-type peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039595 |
induction by virus of catabolism of host mRNA |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039579 |
suppression by virus of host ISG15 activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016032 |
viral process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008233 |
peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039520 |
induction by virus of host autophagy |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039657 |
suppression by virus of host gene expression |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044220 |
host cell perinuclear region of cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Brayton, PR et al. (1982) Characterization of two RNA polymerase activities induced by mouse hepatitis virus. J. Virol. 42 847-53 PubMed GONUTS page
- ↑ 2.0 2.1 Bonilla, PJ et al. (1997) Characterization of a second cleavage site and demonstration of activity in trans by the papain-like proteinase of the murine coronavirus mouse hepatitis virus strain A59. J. Virol. 71 900-9 PubMed GONUTS page
- ↑ Beachboard, DC et al. (2015) Mutations across murine hepatitis virus nsp4 alter virus fitness and membrane modifications. J. Virol. 89 2080-9 PubMed GONUTS page
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- GO:0097264 ! self proteolysis
- ssRNA positive-strand viruses, no DNA stage
- GO:0039548 ! symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity
- GO:0039520 ! symbiont-mediated activation of host autophagy
- GO:0039657 ! symbiont-mediated suppression of host gene expression
- GO:0039648 ! symbiont-mediated perturbation of host ubiquitin-like protein modification
- GO:0039579 ! symbiont-mediated suppression of host ISG15-protein conjugation
- GO:0039595 ! symbiont-mediated degradation of host mRNA
- GO:0039502 ! symbiont-mediated suppression of host type I interferon-mediated signaling pathway
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