CVHNL:SPIKE

Species (Taxon ID)	Human coronavirus NL63 (HCoV-NL63). (277944)
Gene Name(s)	S
Protein Name(s)	Spike glycoprotein S glycoprotein E2 Peplomer protein
External Links
UniProt	Q6Q1S2
EMBL	AY567487 AY518894 AY758297 AY758298 AY758300 AY758301
RefSeq	YP_003767.1
PDB	2IEQ 3KBH 5SZS
PDBsum	2IEQ 3KBH 5SZS
ProteinModelPortal	Q6Q1S2
SMR	Q6Q1S2
DIP	DIP-49012N
GeneID	2943499
KEGG	vg:2943499
KO	K19254
OrthoDB	VOG0900000Z
EvolutionaryTrace	Q6Q1S2
Proteomes	UP000008573 UP000161757
GO	GO:0044173 GO:0016021 GO:0019031 GO:0055036 GO:0046789 GO:0019064 GO:0009405 GO:0046813
Gene3D	1.20.5.790
InterPro	IPR002551 IPR002552 IPR027400
Pfam	PF01600 PF01601

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0019062	virion attachment to host cell	PMID:21798295	ECO:0000315			P		Figures 3c and d show that high expression levels on cell surface are positively correlated with high S protein levels in the virion, therefore, showing this protein helps with attachment/infection.	complete CACAO 12619
involved_in	GO:0046813	receptor-mediated virion attachment to host cell		ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046789	host cell surface receptor binding		ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9BYF1	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002552	C		Seeded From UniProt	complete
part_of	GO:0019031	viral envelope	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002552	C		Seeded From UniProt	complete
involved_in	GO:0019064	fusion of virus membrane with host plasma membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002551	P		Seeded From UniProt	complete
involved_in	GO:0046813	receptor-mediated virion attachment to host cell	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002552	P		Seeded From UniProt	complete
involved_in	GO:0061025	membrane fusion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002552	P		Seeded From UniProt	complete
part_of	GO:0033644	host cell membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1043	C		Seeded From UniProt	complete
part_of	GO:0019031	viral envelope	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0261	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0019012	virion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0946	C		Seeded From UniProt	complete
involved_in	GO:0009405	pathogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0843	P		Seeded From UniProt	complete
involved_in	GO:0046718	viral entry into host cell	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1160	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
involved_in	GO:0019062	virion attachment to host cell	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1161	P		Seeded From UniProt	complete
part_of	GO:0055036	virion membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0275	C		Seeded From UniProt	complete
part_of	GO:0044173	host cell endoplasmic reticulum-Golgi intermediate compartment membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0392	C		Seeded From UniProt	complete
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References

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