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CORGL:MURC

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Species (Taxon ID) Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 /LMG 3730 / NCIMB 10025). (196627)
Gene Name(s) murC (ECO:0000255 with HAMAP-Rule:MF_00046)
Protein Name(s) UDP-N-acetylmuramate--L-alanine ligase (ECO:0000255 with HAMAP-Rule:MF_00046)

UDP-N-acetylmuramoyl-L-alanine synthetase (ECO:0000255 with HAMAP-Rule:MF_00046)

External Links
UniProt P94335
EMBL AB015023
AJ242646
BA000036
BX927154
AB003132
Y08964
RefSeq NP_601359.1
YP_226398.1
ProteinModelPortal P94335
STRING 196627.cg2368
PhosSite P0903515
EnsemblBacteria BAB99550
CAF20497
GeneID 1020109
3345028
KEGG cgl:NCgl2077
PATRIC 21496318
eggNOG COG0773
HOGENOM HOG000256031
KO K01924
OMA FHFIGIG
OrthoDB EOG64BQ73
UniPathway UPA00219
Proteomes UP000000582
UP000001009
GO GO:0005737
GO:0005524
GO:0008763
GO:0007049
GO:0051301
GO:0071555
GO:0009252
GO:0008360
Gene3D 3.40.1190.10
3.40.50.720
3.90.190.20
HAMAP MF_00046
InterPro IPR004101
IPR013221
IPR000713
IPR016040
IPR005758
Pfam PF01225
PF02875
PF08245
SUPFAM SSF53244
SSF53623
TIGRFAMs TIGR01082

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0008763

UDP-N-acetylmuramate-L-alanine ligase activity

PMID:18974047[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

GO:0008763

UDP-N-acetylmuramate-L-alanine ligase activity

PMID:18974047[1]

ECO:0000314

F

Figure 2 shows the phosphorylation by MurC by having lower bands on the gel. Figure 4 Shows the essential domains needed for phosphorylation. Figure 6a Shows that MurC has 100% activity at the phosphorylation site.

complete
CACAO 7746

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000713
InterPro:IPR004101
InterPro:IPR013221
InterPro:IPR036565
InterPro:IPR036615

F

Seeded From UniProt

complete

enables

GO:0008763

UDP-N-acetylmuramate-L-alanine ligase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005758

F

Seeded From UniProt

complete

involved_in

GO:0009058

biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000713
InterPro:IPR004101
InterPro:IPR013221
InterPro:IPR036565
InterPro:IPR036615

P

Seeded From UniProt

complete

involved_in

GO:0009252

peptidoglycan biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005758

P

Seeded From UniProt

complete

enables

GO:0016874

ligase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004101
InterPro:IPR036615

F

Seeded From UniProt

complete

enables

GO:0008763

UDP-N-acetylmuramate-L-alanine ligase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:6.3.2.8

F

Seeded From UniProt

complete

involved_in

GO:0009252

peptidoglycan biosynthetic process

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000163961

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000163961

F

Seeded From UniProt

complete

enables

GO:0008763

UDP-N-acetylmuramate-L-alanine ligase activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000163961

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000163961

C

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

involved_in

GO:0009252

peptidoglycan biosynthetic process

GO_REF:0000037
GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0573
UniPathway:UPA00219

P

Seeded From UniProt

complete

involved_in

GO:0071555

cell wall organization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0961

P

Seeded From UniProt

complete

involved_in

GO:0008360

regulation of cell shape

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0133

P

Seeded From UniProt

complete

enables

GO:0016874

ligase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0436

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

involved_in

GO:0051301

cell division

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0132

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Fiuza, M et al. (2008) The MurC ligase essential for peptidoglycan biosynthesis is regulated by the serine/threonine protein kinase PknA in Corynebacterium glutamicum. J. Biol. Chem. 283 36553-63 PubMed GONUTS page