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CONKI:CM3A
Contents
| Species (Taxon ID) | Conus kinoshitai (Kinoshita's cone). (376876) | |
| Gene Name(s) | No Information Provided. | |
| Protein Name(s) | Mu-conotoxin KIIIA | |
| External Links | ||
| UniProt | P0C195 | |
| PDB | 2LXG | |
| PDBsum | 2LXG | |
| ConoServer | 1694 | |
| GO | GO:0005576 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0044740 |
negative regulation of sensory perception of pain in other organism |
ECO:0000314 |
P |
Figure 2 shows the result of a paw-licking assay with mice. In panel A, injection with KIIIA prior to injection with formalin reduced paw-licking compared to a saline control and a lidocaine injection. Panel B shows the dose-dependence of this pain reduction. |
complete | |||||
|
involved_in |
GO:0009405 |
pathogenesis |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0090729 |
P |
Seeded From UniProt |
complete | ||
| GO:0044489 |
modulation of voltage-gated sodium channel activity in other organism |
ECO:0000314 |
P |
Figures 3 and 4 show KIIIA blocking voltage-gated sodium channels in mice. |
complete | |||||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0090729 |
toxin activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Zhang, MM et al. (2007) Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels. J. Biol. Chem. 282 30699-706 PubMed GONUTS page
