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CLOPF:W8EFP8
Contents
| Species (Taxon ID) | Clostridium perfringens. (1502) | |
| Gene Name(s) | cpa (ECO:0000313 with EMBL:AHJ81248.1) | |
| Protein Name(s) | Alpha toxin (ECO:0000313 with EMBL:AHJ81248.1) | |
| External Links | ||
| UniProt | W8EFP8 | |
| EMBL | KF914160 | |
| STRING | 195103.CPF_0042 | |
| eggNOG | ENOG41064S2 ENOG4112CMR | |
| GO | GO:0004629 GO:0008270 | |
| Gene3D | 1.10.575.10 2.60.60.20 | |
| InterPro | IPR001024 IPR008947 IPR001531 IPR029002 | |
| Pfam | PF01477 PF00882 | |
| PRINTS | PR00479 | |
| ProDom | PD003946 | |
| SMART | SM00770 | |
| SUPFAM | SSF48537 SSF49723 | |
| PROSITE | PS00384 PS51346 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0004629 |
phospholipase C activity |
ECO:0000315 |
F |
Table 1 The effects on hemolytic, PLC, and SMase activities of replacement of the D-56 residue of alpha-toxin with glutamic acid, asparagine, glycine, or serine were investigated. The wild-type toxin at the concentration of 5 ng completely lysed. However, up to 5, 10, and 20mg of the D56E, D56N, D56G, or D56S variant toxins, respectively, exhibited no hemolytic, PLC, and SMase activities. Wild-type shows 100% PLC activity. |
complete | |||||
|
enables |
GO:0004629 |
phospholipase C activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016788 |
hydrolase activity, acting on ester bonds |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Nagahama, M et al. (1997) Site-specific mutagenesis of Clostridium perfringens alpha-toxin: replacement of Asp-56, Asp-130, or Glu-152 causes loss of enzymatic and hemolytic activities. Infect. Immun. 65 3489-92 PubMed GONUTS page
