GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
CLOPF:Q5PXE6
Contents
| Species (Taxon ID) | Clostridium perfringens. (1502) | |
| Gene Name(s) | plc (ECO:0000313 with EMBL:AAV76024.1) | |
| Protein Name(s) | Alpha toxin (ECO:0000313 with EMBL:AAV76024.1) | |
| External Links | ||
| UniProt | Q5PXE6 | |
| EMBL | AY823400 | |
| ProteinModelPortal | Q5PXE6 | |
| SMR | Q5PXE6 | |
| STRING | 195103.CPF_0042 | |
| eggNOG | ENOG41064S2 ENOG4112CMR | |
| GO | GO:0004629 GO:0008270 | |
| Gene3D | 1.10.575.10 2.60.60.20 | |
| InterPro | IPR001024 IPR008947 IPR001531 IPR029002 | |
| Pfam | PF01477 PF00882 | |
| PRINTS | PR00479 | |
| ProDom | PD003946 | |
| SMART | SM00770 | |
| SUPFAM | SSF48537 SSF49723 | |
| PROSITE | PS50095 PS00384 PS51346 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0044507 |
positive regulation of receptor activity in other organism |
ECO:0000314 |
P |
Using direct flourescent binding array, the Clostridium perfringens alpha toxin binds very tightly with ganglioside GM1a because of its lack of sailic acid. The alpha toxin was also shown to induce IL-8 by binding to A549 cells. This was demonstrated by various concentrations of alpha toxin to 549 cells and measuring the amount of IL-8. |
complete | |||||
|
enables |
GO:0004629 |
phospholipase C activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016788 |
hydrolase activity, acting on ester bonds |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0034480 |
phosphatidylcholine phospholipase C activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004629 |
phospholipase C activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000323 |
imported automatically asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Oda, M et al. (2012) Clostridium perfringens alpha-toxin recognizes the GM1a-TrkA complex. J. Biol. Chem. 287 33070-9 PubMed GONUTS page
b
