CLOPE:PHLC1

Species (Taxon ID)	Clostridium perfringens (strain 13 / Type A). (195102)
Gene Name(s)	plc (synonyms: cpa)
Protein Name(s)	Phospholipase C PLC Alpha-toxin Hemolysin Lecithinase Phosphatidylcholine cholinephosphohydrolase
External Links
UniProt	P0C216
EMBL	X17300 D10248 D32123 D32124 D32126 D32127 D32128 D49968 D49969 L43545 L43546 L43547 L43548 D63911 BA000016
PIR	B49231 JQ0366
RefSeq	WP_011009584.1
PDB	1CA1 1GYG 1QM6 1QMD 1SB4
PDBsum	1CA1 1GYG 1QM6 1QMD 1SB4
ProteinModelPortal	P0C216
SMR	P0C216
EnsemblBacteria	BAB79742
GeneID	988262
KEGG	cpe:CPE0036
PATRIC	19493928
KO	K16619
OMA	DHFWDPD
OrthoDB	EOG6PS5WX
BioCyc	CPER195102:GJFM-47-MONOMER
EvolutionaryTrace	P0C216
Proteomes	UP000000818
GO	GO:0005576 GO:0034480 GO:0008270 GO:0044179 GO:0009405
Gene3D	1.10.575.10 2.60.60.20
InterPro	IPR001024 IPR008947 IPR001531 IPR029002
Pfam	PF01477 PF00882
PRINTS	PR00479
ProDom	PD003946
SMART	SM00770
SUPFAM	SSF48537 SSF49723
PROSITE	PS50095 PS00384 PS51346

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0050429	calcium-dependent phospholipase C activity	PMID:9426125	ECO:0000314			F		Table 1: alpha toxin variants decrease phospholipase C activation when Tyr-275 and Tyr-277 are changed in recombinant toxin	complete CACAO 11313
enables	GO:0004629	phospholipase C activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001531	F		Seeded From UniProt	complete
	GO:0007202	activation of phospholipase C activity	PMID:9426125	ECO:0000314			P		Figure 2 shows direct correlation between calcium concentrations and its role on phospholipase C activation.	complete CACAO 11314
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001531	F		Seeded From UniProt	complete
enables	GO:0016788	hydrolase activity, acting on ester bonds	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008947	F		Seeded From UniProt	complete
enables	GO:0034480	phosphatidylcholine phospholipase C activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.4.3	F		Seeded From UniProt	complete
enables	GO:0004629	phospholipase C activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.4.3	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0044179	hemolysis in other organism	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0354	P		Seeded From UniProt	complete
involved_in	GO:0009405	pathogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0843	P		Seeded From UniProt	complete
involved_in	GO:0019835	cytolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0204	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0090729	toxin activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0800	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
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References

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