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CLODI:TOXA

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Species (Taxon ID) Clostridium difficile. (1496)
Gene Name(s) toxA (synonyms: tcdA)
Protein Name(s) Toxin A
External Links
UniProt P16154
EMBL X51797
M30307
X92982
PIR A37052
PDB 2F6E
2G7C
2QJ6
3HO6
4DMV
4DMW
PDBsum 2F6E
2G7C
2QJ6
3HO6
4DMV
4DMW
ProteinModelPortal P16154
SMR P16154
CAZy GT44
MEROPS C80.002
TCDB 1.C.57.1.2
EvolutionaryTrace P16154
GO GO:0016757
GO:0009405
InterPro IPR018337
IPR020974
IPR024770
IPR024772
IPR024769
Pfam PF01473
PF11713
PF12919
PF12920
PF12918
PROSITE PS51170

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0090044

positive regulation of tubulin deacetylation

PMID:20696758[1]

ECO:0000314

P

Fig. 1A.

Note that the GO term cannot beGO:0090042 because ToxA mediates tubulin deacetylation via HDAC6.

complete

involved_in

GO:0009405

pathogenesis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024769

P

Seeded From UniProt

complete

enables

GO:0016757

transferase activity, transferring glycosyl groups

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024770

F

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

P

Seeded From UniProt

complete

enables

GO:0008234

cysteine-type peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0788

F

Seeded From UniProt

complete

involved_in

GO:0009405

pathogenesis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0260

P

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

F

Seeded From UniProt

complete

enables

GO:0090729

toxin activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0800

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Nam, HJ et al. (2010) Clostridium difficile toxin A decreases acetylation of tubulin, leading to microtubule depolymerization through activation of histone deacetylase 6, and this mediates acute inflammation. J. Biol. Chem. 285 32888-96 PubMed GONUTS page