CHICK:RAF1

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	RAF1 (synonyms: MIL)
Protein Name(s)	RAF proto-oncogene serine/threonine-protein kinase C-MIL C-RAF MIL proto-oncogene serine/threonine-protein kinase RAF-1
External Links
UniProt	P05625
EMBL	X07017 K03269 K03259 K03260 K03261 K03262 K03263 K03264 K03265 K03266 K03267 K03268 K03048 K03047 M19461 X55430
PIR	I50382 S00644
RefSeq	NP_990638.1
UniGene	Gga.42842
ProteinModelPortal	P05625
SMR	P05625
PaxDb	P05625
PRIDE	P05625
Ensembl	ENSGALT00000033956
GeneID	396245
KEGG	gga:396245
CTD	5894
eggNOG	COG0515
GeneTree	ENSGT00760000118807
HOGENOM	HOG000252972
HOVERGEN	HBG001886
InParanoid	P05625
KO	K04366
OMA	RMIENNN
OrthoDB	EOG7F5128
PhylomeDB	P05625
TreeFam	TF317006
BRENDA	2.7.11.1
Reactome	REACT_197481 REACT_197905 REACT_232852 REACT_239688 REACT_246236 REACT_247316 REACT_257240
NextBio	20816297
PRO	PR:P05625
Proteomes	UP000000539
GO	GO:0005737 GO:0005794 GO:0005886 GO:0031143 GO:0005524 GO:0046872 GO:0004674 GO:0005057 GO:0071550 GO:0045104 GO:0008285 GO:1902042 GO:0031333 GO:0048011 GO:0033138 GO:0035019
InterPro	IPR020454 IPR011009 IPR002219 IPR000719 IPR017441 IPR003116 IPR001245 IPR008271 IPR029071
Pfam	PF00130 PF07714 PF02196
PRINTS	PR00008
SMART	SM00109 SM00455
SUPFAM	SSF54236 SSF56112
PROSITE	PS00107 PS50011 PS00108 PS50898 PS00479 PS50081

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11345	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11345	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000584608 RGD:3531 UniProtKB:P04049	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000584608 UniProtKB:P04049	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000584576 RGD:2148 UniProtKB:P04049 UniProtKB:P15056	C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88065 MGI:MGI:88190 PANTHER:PTN000584576	C	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003079 MGI:MGI:1346881 MGI:MGI:2443258 PANTHER:PTN001908122 RGD:1359261 RGD:619908 RGD:620063 TAIR:locus:2144613 UniProtKB:O43283 UniProtKB:P04049 UniProtKB:P10398 UniProtKB:P15056 UniProtKB:P80192 UniProtKB:Q02779 UniProtKB:Q13418 UniProtKB:Q13546 UniProtKB:Q16584	F	Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001907370 RGD:3531 WB:WBGene00003030	P	Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:L7RRS6 ensembl:ENSP00000251849	C	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04049 ensembl:ENSP00000251849	P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04049 ensembl:ENSP00000251849	F	Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04049 ensembl:ENSP00000251849	P	Seeded From UniProt	complete
involved_in	GO:0031333	negative regulation of protein complex assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04049 ensembl:ENSP00000251849	P	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04049 ensembl:ENSP00000251849	F	Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04049 ensembl:ENSP00000251849	C	Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04049 ensembl:ENSP00000251849	P	Seeded From UniProt	complete
involved_in	GO:0007190	activation of adenylate cyclase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04049 ensembl:ENSP00000251849	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04049 ensembl:ENSP00000251849	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04049 ensembl:ENSP00000251849	C	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04049 ensembl:ENSP00000251849	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04049 ensembl:ENSP00000251849	C	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04049 ensembl:ENSP00000251849	F	Seeded From UniProt	complete
involved_in	GO:0000186	activation of MAPKK activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04049 ensembl:ENSP00000251849	P	Seeded From UniProt	complete
involved_in	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99N57 ensembl:ENSMUSP00000000451	P	Seeded From UniProt	complete
involved_in	GO:0071550	death-inducing signaling complex assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99N57 ensembl:ENSMUSP00000000451	P	Seeded From UniProt	complete
involved_in	GO:0060324	face development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99N57 ensembl:ENSMUSP00000000451	P	Seeded From UniProt	complete
involved_in	GO:0048538	thymus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99N57 ensembl:ENSMUSP00000000451	P	Seeded From UniProt	complete
involved_in	GO:0048011	neurotrophin TRK receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99N57 ensembl:ENSMUSP00000000451	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99N57 ensembl:ENSMUSP00000000451	P	Seeded From UniProt	complete
involved_in	GO:0045104	intermediate filament cytoskeleton organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99N57 ensembl:ENSMUSP00000000451	P	Seeded From UniProt	complete
involved_in	GO:0035994	response to muscle stretch	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99N57 ensembl:ENSMUSP00000000451	P	Seeded From UniProt	complete
involved_in	GO:0035773	insulin secretion involved in cellular response to glucose stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99N57 ensembl:ENSMUSP00000000451	P	Seeded From UniProt	complete
involved_in	GO:0035019	somatic stem cell population maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99N57 ensembl:ENSMUSP00000000451	P	Seeded From UniProt	complete
part_of	GO:0031143	pseudopodium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99N57 ensembl:ENSMUSP00000000451	C	Seeded From UniProt	complete
involved_in	GO:0030878	thyroid gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99N57 ensembl:ENSMUSP00000000451	P	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99N57 ensembl:ENSMUSP00000000451	P	Seeded From UniProt	complete
enables	GO:0017016	Ras GTPase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99N57 ensembl:ENSMUSP00000000451	F	Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99N57 ensembl:ENSMUSP00000000451	P	Seeded From UniProt	complete
involved_in	GO:0001678	cellular glucose homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99N57 ensembl:ENSMUSP00000000451	P	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008271	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008271	P	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003116	P	Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002219	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[1]

CHICK:RAF1

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