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CHICK:Q9PU44

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) cyp3A37 (ECO:0000313 with EMBL:CAB62060.1)
Protein Name(s) Cytochrome P450 (ECO:0000313 with EMBL:CAB62060.1)
External Links
UniProt Q9PU44
EMBL AJ250337
RefSeq NP_001001751.1
UniGene Gga.1163
ProteinModelPortal Q9PU44
SMR Q9PU44
GeneID 414832
KEGG gga:414832
CTD 1551
HOGENOM HOG000039127
HOVERGEN HBG108567
KO K07424
PhylomeDB Q9PU44
NextBio 20818730
GO GO:0020037
GO:0005506
GO:0016712
Gene3D 1.10.630.10
InterPro IPR001128
IPR017972
IPR008072
IPR002402
Pfam PF00067
PRINTS PR00464
PR01689
PR00385
SUPFAM SSF48264
PROSITE PS00086

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0045177

apical part of cell

PMID:24498193[1]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(CL:0000584)
  • part_of:(UBERON:0002116)
  • part_of:(UBERON:0002115)

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:24498193[1]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(CL:0000182)
  • part_of:(UBERON:0001283)

Seeded From UniProt

complete

part_of

GO:0016324

apical plasma membrane

PMID:24498193[1]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0002113)
  • part_of:(CL:1000507)

Seeded From UniProt

complete

involved_in

GO:0042445

hormone metabolic process

PMID:10620362[2]

ECO:0000314

direct assay evidence used in manual assertion

P

has_direct_input:(CHEBI:17347)|has_direct_input:(CHEBI:16422)

Seeded From UniProt

complete

involved_in

GO:0008202

steroid metabolic process

PMID:10620362[2]

ECO:0000314

direct assay evidence used in manual assertion

P

has_direct_input:(CHEBI:17347)|has_direct_input:(CHEBI:16422)

Seeded From UniProt

complete

involved_in

GO:1901615

organic hydroxy compound metabolic process

PMID:10620362[2]

ECO:0000314

direct assay evidence used in manual assertion

P

has_direct_input:(CHEBI:17347)|has_direct_input:(CHEBI:16422)

Seeded From UniProt

complete

enables

GO:0050649

testosterone 6-beta-hydroxylase activity

PMID:10620362[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0008395

steroid hydroxylase activity

PMID:10620362[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0042448

progesterone metabolic process

PMID:10620362[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005623

cell

PMID:20580800[3]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(UBERON:0002107)

Seeded From UniProt

complete

involved_in

GO:0017144

drug metabolic process

PMID:20580800[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046677

response to antibiotic

PMID:20580800[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043385

mycotoxin metabolic process

PMID:24090734[4]

ECO:0000314

direct assay evidence used in manual assertion

P

has_direct_input:(CHEBI:9381)

Seeded From UniProt

complete

enables

GO:0032451

demethylase activity

PMID:24090734[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0070988

demethylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0032451

P

Seeded From UniProt

complete

enables

GO:0004497

monooxygenase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002402

F

Seeded From UniProt

complete

enables

GO:0005506

iron ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001128
InterPro:IPR002402
InterPro:IPR008072
InterPro:IPR036396

F

Seeded From UniProt

complete

enables

GO:0016705

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001128
InterPro:IPR017972
InterPro:IPR036396

F

Seeded From UniProt

complete

enables

GO:0016712

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008072

F

Seeded From UniProt

complete

enables

GO:0020037

heme binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001128
InterPro:IPR002402
InterPro:IPR008072
InterPro:IPR036396

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001128
InterPro:IPR002402
InterPro:IPR008072
InterPro:IPR017972
InterPro:IPR036396

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

enables

GO:0004497

monooxygenase activity

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0503

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Guo, M et al. (2014) E. coli infection modulates the pharmacokinetics of oral enrofloxacin by targeting P-glycoprotein in small intestine and CYP450 3A in liver and kidney of broilers. PLoS ONE 9 e87781 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Ourlin, JC et al. (2000) Cloning and functional expression of a first inducible avian cytochrome P450 of the CYP3A subfamily (CYP3A37). Arch. Biochem. Biophys. 373 375-84 PubMed GONUTS page
  3. 3.0 3.1 3.2 Zhang, LL et al. (2011) Effects of fluoroquinolones on CYP4501A and 3A in male broilers. Res. Vet. Sci. 90 99-105 PubMed GONUTS page
  4. 4.0 4.1 Yuan, Y et al. (2013) T-2 toxin is hydroxylated by chicken CYP3A37. Food Chem. Toxicol. 62 622-7 PubMed GONUTS page