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CHICK:Q9I8V6

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) LEPR (ECO:0000313 with EMBL:AAF31355.2)
Protein Name(s) Leptin receptor (ECO:0000313 with EMBL:AAF31355.2)
External Links
UniProt Q9I8V6
EMBL AF169827
RefSeq NP_989654.1
UniGene Gga.13
ProteinModelPortal Q9I8V6
GeneID 374223
KEGG gga:374223
CTD 3953
HOGENOM HOG000231995
HOVERGEN HBG000140
KO K05062
PhylomeDB Q9I8V6
NextBio 20813725
GO GO:0016020
GO:0004896
Gene3D 2.60.40.10
InterPro IPR003961
IPR003529
IPR013783
IPR010457
IPR015752
PANTHER PTHR23036:SF11
Pfam PF06328
SMART SM00060
SUPFAM SSF49265
PROSITE PS50853
PS01353

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005623

cell

PMID:19055044[1]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0003984)
  • part_of:(UBERON:0002384)
  • part_of:(UBERON:0001630)
  • part_of:(UBERON:0000483)|part_of:(UBERON:0013516)
  • part_of:(CL:0000160)
  • part_of:(UBERON:0002384)
  • part_of:(UBERON:0001630)|part_of:(UBERON:0008975)

Seeded From UniProt

complete

involved_in

GO:0010629

negative regulation of gene expression

PMID:25447880[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • occurs_in:(UBERON:0002107)
  • occurs_in:(UBERON:0001898)
  • occurs_in:(UBERON:0001495)
  • occurs_in:(UBERON:0007808)

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:25447880[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • occurs_in:(UBERON:0002107)
  • occurs_in:(UBERON:0001898)
  • occurs_in:(UBERON:0001495)
  • occurs_in:(UBERON:0007808)

Seeded From UniProt

complete

involved_in

GO:0001934

positive regulation of protein phosphorylation

PMID:25447880[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0002107)

Seeded From UniProt

complete

involved_in

GO:0006112

energy reserve metabolic process

PMID:25447880[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010887

negative regulation of cholesterol storage

PMID:25447880[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045717

negative regulation of fatty acid biosynthetic process

PMID:25447880[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032100

positive regulation of appetite

PMID:25447880[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010629

negative regulation of gene expression

PMID:24650216[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • occurs_in:(UBERON:0001898)
  • occurs_in:(UBERON:0000155)
  • occurs_in:(UBERON:0005170)
  • occurs_in:(UBERON:0007808)

Seeded From UniProt

complete

involved_in

GO:0032099

negative regulation of appetite

PMID:24650216[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001552

ovarian follicle atresia

PMID:24650216[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2000355

negative regulation of ovarian follicle development

PMID:24650216[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:24650216[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • occurs_in:(UBERON:0001898)
  • occurs_in:(UBERON:0002107)
  • occurs_in:(UBERON:0000155)
  • occurs_in:(UBERON:0005170)

Seeded From UniProt

complete

involved_in

GO:0046321

positive regulation of fatty acid oxidation

PMID:25447880[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0019221

cytokine-mediated signaling pathway

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004896

P

Seeded From UniProt

complete

involved_in

GO:0033210

leptin-mediated signaling pathway

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0038021

P

Seeded From UniProt

complete

enables

GO:0004896

cytokine receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003529

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003529

C

Seeded From UniProt

complete

enables

GO:0038021

leptin receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR015752

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Grzegorzewska, AK et al. (2008) MRNA expression and immunocytochemical localization of leptin receptor in the oviduct of the laying hen (Gallus domesticus). Folia Biol. (Krakow) 56 179-85 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Lei, MM et al. (2015) Creating leptin-like biofunctions by active immunization against chicken leptin receptor in growing chickens. Domest. Anim. Endocrinol. 50 55-64 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 Lei, MM et al. (2014) Leptin receptor signaling inhibits ovarian follicle development and egg laying in chicken hens. Reprod. Biol. Endocrinol. 12 25 PubMed GONUTS page