CHICK:Q9I8D2

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	IL-18 (ECO:0000313 with EMBL:CAB96214.1) (synonyms: IL18 (ECO:0000313 with EMBL:ABY55308.1))
Protein Name(s)	Interleukin 18 (ECO:0000313 with EMBL:CAB96214.1) Interleukin-18 (ECO:0000313 with EMBL:AAV52772.1)
External Links
UniProt	Q9I8D2
EMBL	AY775780 AY775782 EU334505 FJ788632 AJ277865
RefSeq	NP_989939.1
UniGene	Gga.17593
ProteinModelPortal	Q9I8D2
PRIDE	Q9I8D2
GeneID	395312
KEGG	gga:395312
CTD	3606
HOVERGEN	HBG102119
KO	K05482
Reactome	REACT_197474
NextBio	20815397
ExpressionAtlas	Q9I8D2
GO	GO:0005615 GO:0070062 GO:0001525 GO:0071407 GO:0006954 GO:0031663 GO:0000165 GO:0030101 GO:0042104 GO:0010628 GO:0032725 GO:0032729 GO:0032740 GO:0032819 GO:0042346 GO:0051142 GO:0030155 GO:0042088
InterPro	IPR008996 IPR015529 IPR000975
PANTHER	PTHR11326
Pfam	PF00340
PIRSF	PIRSF015162
PRINTS	PR01933
SUPFAM	SSF50353

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0035710	CD4-positive, alpha-beta T cell activation	PMID:12902481^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050671	positive regulation of lymphocyte proliferation	PMID:12902481^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000492)	Seeded From UniProt	complete
involved_in	GO:1902715	positive regulation of interferon-gamma secretion	PMID:12902481^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000492)	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:2000556	positive regulation of T-helper 1 cell cytokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14116 ensembl:ENSP00000280357	P		Seeded From UniProt	complete
involved_in	GO:0071407	cellular response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14116 ensembl:ENSP00000280357	P		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14116 ensembl:ENSP00000280357	P		Seeded From UniProt	complete
involved_in	GO:0051142	positive regulation of NK T cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14116 ensembl:ENSP00000280357	P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14116 ensembl:ENSP00000280357	P		Seeded From UniProt	complete
involved_in	GO:0048661	positive regulation of smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14116 ensembl:ENSP00000280357	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14116 ensembl:ENSP00000280357	P		Seeded From UniProt	complete
enables	GO:0045515	interleukin-18 receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14116 ensembl:ENSP00000280357	F		Seeded From UniProt	complete
involved_in	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14116 ensembl:ENSP00000280357	P		Seeded From UniProt	complete
involved_in	GO:0042104	positive regulation of activated T cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14116 ensembl:ENSP00000280357	P		Seeded From UniProt	complete
involved_in	GO:0042088	T-helper 1 type immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14116 ensembl:ENSP00000280357	P		Seeded From UniProt	complete
involved_in	GO:0035655	interleukin-18-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14116 ensembl:ENSP00000280357	P		Seeded From UniProt	complete
involved_in	GO:0032819	positive regulation of natural killer cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14116 ensembl:ENSP00000280357	P		Seeded From UniProt	complete
involved_in	GO:0032740	positive regulation of interleukin-17 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14116 ensembl:ENSP00000280357	P		Seeded From UniProt	complete
involved_in	GO:0032729	positive regulation of interferon-gamma production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14116 ensembl:ENSP00000280357	P		Seeded From UniProt	complete
involved_in	GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14116 ensembl:ENSP00000280357	P		Seeded From UniProt	complete
involved_in	GO:0032148	activation of protein kinase B activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14116 ensembl:ENSP00000280357	P		Seeded From UniProt	complete
involved_in	GO:0031663	lipopolysaccharide-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14116 ensembl:ENSP00000280357	P		Seeded From UniProt	complete
involved_in	GO:0030155	regulation of cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14116 ensembl:ENSP00000280357	P		Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14116 ensembl:ENSP00000280357	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14116 ensembl:ENSP00000280357	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14116 ensembl:ENSP00000280357	C		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14116 ensembl:ENSP00000280357	F		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14116 ensembl:ENSP00000280357	P		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14116 ensembl:ENSP00000280357	P		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000975	F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000975	C		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000975	P		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000975	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0964	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000040	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000483752	C		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000483752	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Göbel, TW et al. (2003) IL-18 stimulates the proliferation and IFN-gamma release of CD4+ T cells in the chicken: conservation of a Th1-like system in a nonmammalian species. J. Immunol. 171 1809-15 PubMed GONUTS page

[PMID:12902481-1] 1.0 ^1.1 ^1.2 Göbel, TW et al. (2003) IL-18 stimulates the proliferation and IFN-gamma release of CD4+ T cells in the chicken: conservation of a Th1-like system in a nonmammalian species. J. Immunol. 171 1809-15 PubMed GONUTS page

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CHICK:Q9I8D2

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