CHICK:Q98945

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	No Information Provided.
Protein Name(s)	Protein tyrosine phosphatase CRYP-2 (ECO:0000313 with EMBL:AAB17968.1)
External Links
UniProt	Q98945
EMBL	U65891
RefSeq	NP_989453.1
UniGene	Gga.142
PDB	2PI7
PDBsum	2PI7
ProteinModelPortal	Q98945
SMR	Q98945
STRING	9031.ENSGALP00000021332
PaxDb	Q98945
GeneID	373911
KEGG	gga:373911
CTD	5800
eggNOG	COG5599
HOGENOM	HOG000115792
HOVERGEN	HBG053763
KO	K18035
PhylomeDB	Q98945
EvolutionaryTrace	Q98945
NextBio	20813443
GO	GO:0016324 GO:0030424 GO:0043197 GO:0030426 GO:0030027 GO:0016328 GO:0043005 GO:0005886 GO:0042803 GO:0004725 GO:0017147 GO:0007411 GO:0000902 GO:0072112 GO:0032835 GO:0030032 GO:0002548 GO:0008045 GO:0090090 GO:0010812 GO:0003105 GO:0010977 GO:0090260 GO:0035335 GO:0003093 GO:0036060
Gene3D	2.60.40.10 3.90.190.10
InterPro	IPR003961 IPR013783 IPR029021 IPR000387 IPR016130 IPR000242
Pfam	PF00041 PF00102
PRINTS	PR00700
SMART	SM00060 SM00194
SUPFAM	SSF49265 SSF52799
PROSITE	PS50853 PS00383 PS50056 PS50055

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0090260	negative regulation of retinal ganglion cell axon guidance	PMID:11514594^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:E9Q612	P		Seeded From UniProt	complete
involved_in	GO:0072112	glomerular visceral epithelial cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:E9Q612	P		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:E9Q612	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:10213455^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:E9Q612	F		Seeded From UniProt	complete
involved_in	GO:0036060	slit diaphragm assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:E9Q612	P		Seeded From UniProt	complete
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	PMID:19573017^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032835	glomerulus development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q16827	P		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	PMID:10213455^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:10213455^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030032	lamellipodium assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:E9Q612	P		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	PMID:10213455^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:E9Q612	F		Seeded From UniProt	complete
part_of	GO:0016328	lateral plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:E9Q612	C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:E9Q612	C		Seeded From UniProt	complete
involved_in	GO:0010977	negative regulation of neuron projection development	PMID:11514594^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010812	negative regulation of cell-substrate adhesion	PMID:11514594^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000101)	Seeded From UniProt	complete
involved_in	GO:0008045	motor neuron axon guidance	PMID:15829633^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:E9Q612	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:E9Q612	C		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	PMID:19573017^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:Q16288)	Seeded From UniProt	complete
involved_in	GO:0003105	negative regulation of glomerular filtration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62797	P		Seeded From UniProt	complete
involved_in	GO:0003093	regulation of glomerular filtration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:E9Q612	P		Seeded From UniProt	complete
involved_in	GO:0002548	monocyte chemotaxis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q16827	P		Seeded From UniProt	complete
involved_in	GO:0000902	cell morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:E9Q612	P		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000242 InterPro:IPR016130	F		Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000242	P		Seeded From UniProt	complete
involved_in	GO:0016311	dephosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000387 InterPro:IPR016130	P		Seeded From UniProt	complete
enables	GO:0016791	phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000387	F		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.3.48	F		Seeded From UniProt	complete
enables	GO:0004721	phosphoprotein phosphatase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0904	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000414439	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Stepanek, L et al. (2001) CRYP-2/cPTPRO is a neurite inhibitory repulsive guidance cue for retinal neurons in vitro. J. Cell Biol. 154 867-78 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Ledig, MM et al. (1999) Expression of receptor tyrosine phosphatases during development of the retinotectal projection of the chick. J. Neurobiol. 39 81-96 PubMed GONUTS page
↑ ^3.0 ^3.1 Hower, AE et al. (2009) Dimerization of tyrosine phosphatase PTPRO decreases its activity and ability to inactivate TrkC. J. Neurochem. 110 1635-47 PubMed GONUTS page
↑ Stepanek, L et al. (2005) Receptor tyrosine phosphatases guide vertebrate motor axons during development. J. Neurosci. 25 3813-23 PubMed GONUTS page

[PMID:11514594-1] 1.0 ^1.1 ^1.2 Stepanek, L et al. (2001) CRYP-2/cPTPRO is a neurite inhibitory repulsive guidance cue for retinal neurons in vitro. J. Cell Biol. 154 867-78 PubMed GONUTS page

[PMID:10213455-2] 2.0 ^2.1 ^2.2 ^2.3 Ledig, MM et al. (1999) Expression of receptor tyrosine phosphatases during development of the retinotectal projection of the chick. J. Neurobiol. 39 81-96 PubMed GONUTS page

[PMID:19573017-3] 3.0 ^3.1 Hower, AE et al. (2009) Dimerization of tyrosine phosphatase PTPRO decreases its activity and ability to inactivate TrkC. J. Neurochem. 110 1635-47 PubMed GONUTS page

[PMID:15829633-4] Stepanek, L et al. (2005) Receptor tyrosine phosphatases guide vertebrate motor axons during development. J. Neurosci. 25 3813-23 PubMed GONUTS page

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CHICK:Q98945

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References

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