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CHICK:Q90ZG0
Contents
Species (Taxon ID) | Gallus gallus (Chicken). (9031) | |
Gene Name(s) | FKBP12 (ECO:0000313 with EMBL:BAB56111.1) | |
Protein Name(s) | Peptidyl-prolyl cis-trans isomerase (ECO:0000256 with RuleBase:RU004231) | |
External Links | ||
UniProt | Q90ZG0 | |
EMBL | AB055761 | |
RefSeq | NP_989661.1 | |
UniGene | Gga.56362 | |
ProteinModelPortal | Q90ZG0 | |
SMR | Q90ZG0 | |
PRIDE | Q90ZG0 | |
GeneID | 374233 | |
KEGG | gga:374233 | |
CTD | 2280 | |
HOVERGEN | HBG051623 | |
KO | K09568 | |
PhylomeDB | Q90ZG0 | |
Reactome | REACT_198125 | |
NextBio | 20813732 | |
PRO | PR:Q90ZG0 | |
ExpressionAtlas | Q90ZG0 | |
GO | GO:0030424 GO:0043231 GO:0043204 GO:0033017 GO:0005528 GO:0003755 GO:0007420 GO:0019221 GO:0009792 GO:0007507 GO:0060347 GO:0060173 GO:0001889 GO:0030324 GO:0006936 GO:0010614 GO:0001933 GO:0010615 GO:0060452 GO:0006457 GO:0055117 GO:0060314 GO:0051209 GO:0031000 GO:0048745 GO:0048536 GO:0042098 GO:0055010 | |
InterPro | IPR023566 IPR001179 | |
PANTHER | PTHR10516 | |
Pfam | PF00254 | |
PROSITE | PS50059 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
part_of |
GO:0014802 |
terminal cisterna |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0008144 |
drug binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060314 |
regulation of ryanodine-sensitive calcium-release channel activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:1990000 |
amyloid fibril formation |
ECO:0000247 |
sequence alignment evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:1902991 |
regulation of amyloid precursor protein catabolic process |
ECO:0000247 |
sequence alignment evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0070062 |
extracellular exosome |
ECO:0000247 |
sequence alignment evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060347 |
heart trabecula formation |
ECO:0000247 |
sequence alignment evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060315 |
negative regulation of ryanodine-sensitive calcium-release channel activity |
ECO:0000247 |
sequence alignment evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060314 |
regulation of ryanodine-sensitive calcium-release channel activity |
ECO:0000247 |
sequence alignment evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060314 |
regulation of ryanodine-sensitive calcium-release channel activity |
ECO:0000247 |
sequence alignment evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0055010 |
ventricular cardiac muscle tissue morphogenesis |
ECO:0000247 |
sequence alignment evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051280 |
negative regulation of release of sequestered calcium ion into cytosol |
ECO:0000247 |
sequence alignment evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051209 |
release of sequestered calcium ion into cytosol |
ECO:0000247 |
sequence alignment evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050776 |
regulation of immune response |
ECO:0000247 |
sequence alignment evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0048185 |
activin binding |
ECO:0000247 |
sequence alignment evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0046332 |
SMAD binding |
ECO:0000247 |
sequence alignment evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0044325 |
ion channel binding |
ECO:0000247 |
sequence alignment evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0097435 |
supramolecular fiber organization |
ECO:0000247 |
sequence alignment evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043123 |
positive regulation of I-kappaB kinase/NF-kappaB signaling |
ECO:0000247 |
sequence alignment evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000247 |
sequence alignment evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042098 |
T cell proliferation |
ECO:0000247 |
sequence alignment evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0033017 |
sarcoplasmic reticulum membrane |
ECO:0000247 |
sequence alignment evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032925 |
regulation of activin receptor signaling pathway |
ECO:0000247 |
sequence alignment evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032880 |
regulation of protein localization |
ECO:0000247 |
sequence alignment evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032515 |
negative regulation of phosphoprotein phosphatase activity |
ECO:0000247 |
sequence alignment evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032092 |
positive regulation of protein binding |
ECO:0000247 |
sequence alignment evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0031398 |
positive regulation of protein ubiquitination |
ECO:0000247 |
sequence alignment evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0031000 |
response to caffeine |
ECO:0000247 |
sequence alignment evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0030018 |
Z disc |
ECO:0000247 |
sequence alignment evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0019855 |
calcium channel inhibitor activity |
ECO:0000247 |
sequence alignment evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0019221 |
cytokine-mediated signaling pathway |
ECO:0000247 |
sequence alignment evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000247 |
sequence alignment evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000247 |
sequence alignment evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0008144 |
drug binding |
ECO:0000247 |
sequence alignment evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007183 |
SMAD protein complex assembly |
ECO:0000247 |
sequence alignment evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006936 |
muscle contraction |
ECO:0000247 |
sequence alignment evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
ECO:0000247 |
sequence alignment evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
ECO:0000247 |
sequence alignment evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000247 |
sequence alignment evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005528 |
FK506 binding |
ECO:0000247 |
sequence alignment evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005528 |
FK506 binding |
ECO:0000247 |
sequence alignment evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003755 |
peptidyl-prolyl cis-trans isomerase activity |
ECO:0000247 |
sequence alignment evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003755 |
peptidyl-prolyl cis-trans isomerase activity |
ECO:0000247 |
sequence alignment evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0003007 |
heart morphogenesis |
ECO:0000247 |
sequence alignment evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0001933 |
negative regulation of protein phosphorylation |
ECO:0000247 |
sequence alignment evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0000413 |
protein peptidyl-prolyl isomerization |
ECO:0000247 |
sequence alignment evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0000413 |
protein peptidyl-prolyl isomerization |
ECO:0000247 |
sequence alignment evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0086003 |
cardiac muscle cell contraction |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(CL:0002495) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0070884 |
regulation of calcineurin-NFAT signaling cascade |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(CL:0002495) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005623 |
cell |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0002165) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010880 |
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(UBERON:0001134) |
Seeded From UniProt |
complete | ||
part_of |
GO:0014802 |
terminal cisterna |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001134) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060452 |
positive regulation of cardiac muscle contraction |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060173 |
limb development |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0048745 |
smooth muscle tissue development |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0048536 |
spleen development |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0043231 |
intracellular membrane-bounded organelle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0043204 |
perikaryon |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
NOT|involved_in |
GO:0032526 |
response to retinoic acid |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0030424 |
axon |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030324 |
lung development |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010615 |
positive regulation of cardiac muscle adaptation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010614 |
negative regulation of cardiac muscle hypertrophy |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0009792 |
embryo development ending in birth or egg hatching |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0009792 |
embryo development ending in birth or egg hatching |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0009792 |
embryo development ending in birth or egg hatching |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007507 |
heart development |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007507 |
heart development |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007420 |
brain development |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0001889 |
liver development |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0061077 |
chaperone-mediated protein folding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000054102 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000054102 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0003755 |
peptidyl-prolyl cis-trans isomerase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
CGD:CAL0000188340 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0000413 |
protein peptidyl-prolyl isomerization |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000054102 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060347 |
heart trabecula formation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26883 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060314 |
regulation of ryanodine-sensitive calcium-release channel activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26883 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0055010 |
ventricular cardiac muscle tissue morphogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26883 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051209 |
release of sequestered calcium ion into cytosol |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26883 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0045202 |
synapse |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26883 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0044325 |
ion channel binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26883 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26883 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042098 |
T cell proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26883 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0033017 |
sarcoplasmic reticulum membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26883 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0031000 |
response to caffeine |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26883 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0019221 |
cytokine-mediated signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26883 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0016020 |
membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26883 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0008144 |
drug binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26883 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006936 |
muscle contraction |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26883 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0005528 |
FK506 binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26883 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0003007 |
heart morphogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26883 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001933 |
negative regulation of protein phosphorylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P26883 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0003755 |
peptidyl-prolyl cis-trans isomerase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0016853 |
isomerase activity |
ECO:0000323 |
imported automatically asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003755 |
peptidyl-prolyl cis-trans isomerase activity |
ECO:0000323 |
imported automatically asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0016853 |
isomerase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000413783 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0055117 |
regulation of cardiac muscle contraction |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Qi, Y et al. (1998) FK-binding protein is associated with the ryanodine receptor of skeletal muscle in vertebrate animals. J. Biol. Chem. 273 34813-9 PubMed GONUTS page
- ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 2.12 2.13 2.14 2.15 2.16 2.17 2.18 2.19 2.20 2.21 2.22 2.23 2.24 2.25 2.26 2.27 2.28 2.29 2.30 2.31 2.32 2.33 2.34 2.35 2.36 2.37 2.38 2.39 2.40 2.41 2.42 2.43 2.44 2.45 2.46 2.47 2.48 2.49 2.50 2.51 Obata, K et al. (2001) Role of FK506-binding protein 12 in development of the chick embryonic heart. Biochem. Biophys. Res. Commun. 283 613-20 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 3.9 Yazawa, S et al. (2003) Gene expression of FK506-binding proteins 12.6 and 12 during chicken development. Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. 136 391-9 PubMed GONUTS page
- ↑ Jeyakumar, LH et al. (2001) FKBP binding characteristics of cardiac microsomes from diverse vertebrates. Biochem. Biophys. Res. Commun. 281 979-86 PubMed GONUTS page
- ↑ 5.0 5.1 Zeilhofer, HU et al. (2000) Calcium-dependent inactivation of neuronal calcium channel currents is independent of calcineurin. Neuroscience 95 235-41 PubMed GONUTS page
- ↑ Yazawa, S et al. (2003) Heart-selective expression of the chicken FK506-binding protein (FKBP) 12.6 gene during embryonic development. Dev. Dyn. 226 33-41 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
a
c
e
h
n
- GO:0051280 ! negative regulation of release of sequestered calcium ion into cytosol
- GO:0010614 ! negative regulation of cardiac muscle hypertrophy
- GO:0060315 ! negative regulation of ryanodine-sensitive calcium-release channel activity
- GO:0001933 ! negative regulation of protein phosphorylation
- Neognathae
o
p
- GO:0003755 ! peptidyl-prolyl cis-trans isomerase activity
- GO:0043204 ! perikaryon
- Phasianidae
- Phasianinae
- GO:0010615 ! positive regulation of cardiac muscle adaptation
- GO:0043123 ! positive regulation of canonical NF-kappaB signal transduction
- GO:0031398 ! positive regulation of protein ubiquitination
- GO:0032092 ! positive regulation of protein binding
- GO:0060452 ! positive regulation of cardiac muscle contraction
- GO:0042803 ! protein homodimerization activity
- GO:0000413 ! protein peptidyl-prolyl isomerization
r
- GO:1902991 ! regulation of amyloid precursor protein catabolic process
- GO:0032925 ! regulation of activin receptor signaling pathway
- GO:0050776 ! regulation of immune response
- GO:0060314 ! regulation of ryanodine-sensitive calcium-release channel activity
- GO:0055117 ! regulation of cardiac muscle contraction
- GO:0010880 ! regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
- GO:0032880 ! regulation of protein localization
- GO:0070884 ! regulation of calcineurin-NFAT signaling cascade
- GO:0051209 ! release of sequestered calcium ion into cytosol
- GO:0032526 ! response to retinoic acid
- GO:0031000 ! response to caffeine
s
t