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CHICK:Q90ZG0

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) FKBP12 (ECO:0000313 with EMBL:BAB56111.1)
Protein Name(s) Peptidyl-prolyl cis-trans isomerase (ECO:0000256 with RuleBase:RU004231)
External Links
UniProt Q90ZG0
EMBL AB055761
RefSeq NP_989661.1
UniGene Gga.56362
ProteinModelPortal Q90ZG0
SMR Q90ZG0
PRIDE Q90ZG0
GeneID 374233
KEGG gga:374233
CTD 2280
HOVERGEN HBG051623
KO K09568
PhylomeDB Q90ZG0
Reactome REACT_198125
NextBio 20813732
PRO PR:Q90ZG0
ExpressionAtlas Q90ZG0
GO GO:0030424
GO:0043231
GO:0043204
GO:0033017
GO:0005528
GO:0003755
GO:0007420
GO:0019221
GO:0009792
GO:0007507
GO:0060347
GO:0060173
GO:0001889
GO:0030324
GO:0006936
GO:0010614
GO:0001933
GO:0010615
GO:0060452
GO:0006457
GO:0055117
GO:0060314
GO:0051209
GO:0031000
GO:0048745
GO:0048536
GO:0042098
GO:0055010
InterPro IPR023566
IPR001179
PANTHER PTHR10516
Pfam PF00254
PROSITE PS50059

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0014802

terminal cisterna

PMID:9857007[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0008144

drug binding

PMID:9857007[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0060314

regulation of ryanodine-sensitive calcium-release channel activity

PMID:9857007[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1990000

amyloid fibril formation

PMID:11341768[2]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P62942

P

Seeded From UniProt

complete

involved_in

GO:1902991

regulation of amyloid precursor protein catabolic process

PMID:11341768[2]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P62942

P

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:11341768[2]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P62942

C

Seeded From UniProt

complete

involved_in

GO:0060347

heart trabecula formation

PMID:11341768[2]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P26883

P

Seeded From UniProt

complete

involved_in

GO:0060315

negative regulation of ryanodine-sensitive calcium-release channel activity

PMID:11341768[2]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P62942

P

Seeded From UniProt

complete

involved_in

GO:0060314

regulation of ryanodine-sensitive calcium-release channel activity

PMID:11341768[2]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P26883

P

Seeded From UniProt

complete

involved_in

GO:0060314

regulation of ryanodine-sensitive calcium-release channel activity

PMID:11341768[2]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P62942

P

Seeded From UniProt

complete

involved_in

GO:0055010

ventricular cardiac muscle tissue morphogenesis

PMID:11341768[2]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P26883

P

Seeded From UniProt

complete

involved_in

GO:0051280

negative regulation of release of sequestered calcium ion into cytosol

PMID:11341768[2]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P62942

P

Seeded From UniProt

complete

involved_in

GO:0051209

release of sequestered calcium ion into cytosol

PMID:11341768[2]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P26883

P

Seeded From UniProt

complete

involved_in

GO:0050776

regulation of immune response

PMID:11341768[2]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P62942

P

Seeded From UniProt

complete

enables

GO:0048185

activin binding

PMID:11341768[2]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P62942

F

Seeded From UniProt

complete

enables

GO:0046332

SMAD binding

PMID:11341768[2]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P62942

F

Seeded From UniProt

complete

enables

GO:0044325

ion channel binding

PMID:11341768[2]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P26883

F

Seeded From UniProt

complete

involved_in

GO:0097435

supramolecular fiber organization

PMID:11341768[2]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P62942

P

Seeded From UniProt

complete

involved_in

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

PMID:11341768[2]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P62942

P

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

PMID:11341768[2]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P26883

F

Seeded From UniProt

complete

involved_in

GO:0042098

T cell proliferation

PMID:11341768[2]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P26883

P

Seeded From UniProt

complete

part_of

GO:0033017

sarcoplasmic reticulum membrane

PMID:11341768[2]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P26883

C

Seeded From UniProt

complete

involved_in

GO:0032925

regulation of activin receptor signaling pathway

PMID:11341768[2]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P62942

P

Seeded From UniProt

complete

involved_in

GO:0032880

regulation of protein localization

PMID:11341768[2]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P62942

P

Seeded From UniProt

complete

involved_in

GO:0032515

negative regulation of phosphoprotein phosphatase activity

PMID:11341768[2]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P62942

P

Seeded From UniProt

complete

involved_in

GO:0032092

positive regulation of protein binding

PMID:11341768[2]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P62942

P

Seeded From UniProt

complete

involved_in

GO:0031398

positive regulation of protein ubiquitination

PMID:11341768[2]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P62942

P

Seeded From UniProt

complete

involved_in

GO:0031000

response to caffeine

PMID:11341768[2]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P26883

P

Seeded From UniProt

complete

part_of

GO:0030018

Z disc

PMID:11341768[2]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P62942

C

Seeded From UniProt

complete

enables

GO:0019855

calcium channel inhibitor activity

PMID:11341768[2]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P62942

F

Seeded From UniProt

complete

involved_in

GO:0019221

cytokine-mediated signaling pathway

PMID:11341768[2]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P26883

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:11341768[2]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P62942

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:11341768[2]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P26883

C

Seeded From UniProt

complete

enables

GO:0008144

drug binding

PMID:11341768[2]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P26883

F

Seeded From UniProt

complete

involved_in

GO:0007183

SMAD protein complex assembly

PMID:11341768[2]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P62942

P

Seeded From UniProt

complete

involved_in

GO:0006936

muscle contraction

PMID:11341768[2]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P26883

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:11341768[2]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P18203

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:11341768[2]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P62942

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:11341768[2]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P62942

C

Seeded From UniProt

complete

enables

GO:0005528

FK506 binding

PMID:11341768[2]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P26883

F

Seeded From UniProt

complete

enables

GO:0005528

FK506 binding

PMID:11341768[2]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P62942

F

Seeded From UniProt

complete

enables

GO:0003755

peptidyl-prolyl cis-trans isomerase activity

PMID:11341768[2]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P18203

F

Seeded From UniProt

complete

enables

GO:0003755

peptidyl-prolyl cis-trans isomerase activity

PMID:11341768[2]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P62942

F

Seeded From UniProt

complete

involved_in

GO:0003007

heart morphogenesis

PMID:11341768[2]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P26883

P

Seeded From UniProt

complete

involved_in

GO:0001933

negative regulation of protein phosphorylation

PMID:11341768[2]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P26883

P

Seeded From UniProt

complete

involved_in

GO:0000413

protein peptidyl-prolyl isomerization

PMID:11341768[2]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P62942

P

Seeded From UniProt

complete

involved_in

GO:0000413

protein peptidyl-prolyl isomerization

PMID:11341768[2]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P18203

P

Seeded From UniProt

complete

involved_in

GO:0086003

cardiac muscle cell contraction

PMID:11341768[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:0002495)

Seeded From UniProt

complete

involved_in

GO:0070884

regulation of calcineurin-NFAT signaling cascade

PMID:11341768[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:0002495)

Seeded From UniProt

complete

part_of

GO:0005623

cell

PMID:11341768[2]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(UBERON:0002165)

Seeded From UniProt

complete

involved_in

GO:0010880

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

PMID:9857007[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0001134)

Seeded From UniProt

complete

part_of

GO:0014802

terminal cisterna

PMID:9857007[1]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(UBERON:0001134)

Seeded From UniProt

complete

involved_in

GO:0060452

positive regulation of cardiac muscle contraction

PMID:11341768[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060173

limb development

PMID:14511757[3]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048745

smooth muscle tissue development

PMID:14511757[3]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048536

spleen development

PMID:14511757[3]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0043231

intracellular membrane-bounded organelle

PMID:11237759[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0043204

perikaryon

PMID:10619480[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

NOT|involved_in

GO:0032526

response to retinoic acid

PMID:14511757[3]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0030424

axon

PMID:10619480[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0030324

lung development

PMID:14511757[3]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010615

positive regulation of cardiac muscle adaptation

PMID:11341768[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010614

negative regulation of cardiac muscle hypertrophy

PMID:11341768[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009792

embryo development ending in birth or egg hatching

PMID:14511757[3]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009792

embryo development ending in birth or egg hatching

PMID:11341768[2]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009792

embryo development ending in birth or egg hatching

PMID:12508222[6]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007507

heart development

PMID:11341768[2]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007507

heart development

PMID:14511757[3]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007420

brain development

PMID:14511757[3]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001889

liver development

PMID:14511757[3]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0061077

chaperone-mediated protein folding

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000054102
UniProtKB:Q02790
UniProtKB:Q13451

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000054102
UniProtKB:P62942
UniProtKB:P68106
UniProtKB:Q38931
UniProtKB:Q8I4V8

C

Seeded From UniProt

complete

enables

GO:0003755

peptidyl-prolyl cis-trans isomerase activity

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

CGD:CAL0000188340
MGI:MGI:1336205
PANTHER:PTN000054102
PomBase:SPAC27F1.06c
SGD:S000005079
UniProtKB:P18203
UniProtKB:P62942
UniProtKB:P68106
UniProtKB:Q02790
UniProtKB:Q13451
UniProtKB:Q8I4V8
WB:WBGene00001431

F

Seeded From UniProt

complete

involved_in

GO:0000413

protein peptidyl-prolyl isomerization

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000054102
UniProtKB:P62942
UniProtKB:P68106
WB:WBGene00001431

P

Seeded From UniProt

complete

involved_in

GO:0060347

heart trabecula formation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26883
ensembl:ENSMUSP00000037206

P

Seeded From UniProt

complete

involved_in

GO:0060314

regulation of ryanodine-sensitive calcium-release channel activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26883
ensembl:ENSMUSP00000037206

P

Seeded From UniProt

complete

involved_in

GO:0055010

ventricular cardiac muscle tissue morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26883
ensembl:ENSMUSP00000037206

P

Seeded From UniProt

complete

involved_in

GO:0051209

release of sequestered calcium ion into cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26883
ensembl:ENSMUSP00000037206

P

Seeded From UniProt

complete

part_of

GO:0045202

synapse

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26883
ensembl:ENSMUSP00000037206

C

Seeded From UniProt

complete

enables

GO:0044325

ion channel binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26883
ensembl:ENSMUSP00000037206

F

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26883
ensembl:ENSMUSP00000037206

F

Seeded From UniProt

complete

involved_in

GO:0042098

T cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26883
ensembl:ENSMUSP00000037206

P

Seeded From UniProt

complete

part_of

GO:0033017

sarcoplasmic reticulum membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26883
ensembl:ENSMUSP00000037206

C

Seeded From UniProt

complete

involved_in

GO:0031000

response to caffeine

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26883
ensembl:ENSMUSP00000037206

P

Seeded From UniProt

complete

involved_in

GO:0019221

cytokine-mediated signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26883
ensembl:ENSMUSP00000037206

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26883
ensembl:ENSMUSP00000037206

C

Seeded From UniProt

complete

enables

GO:0008144

drug binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26883
ensembl:ENSMUSP00000037206

F

Seeded From UniProt

complete

involved_in

GO:0006936

muscle contraction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26883
ensembl:ENSMUSP00000037206

P

Seeded From UniProt

complete

enables

GO:0005528

FK506 binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26883
ensembl:ENSMUSP00000037206

F

Seeded From UniProt

complete

involved_in

GO:0003007

heart morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26883
ensembl:ENSMUSP00000037206

P

Seeded From UniProt

complete

involved_in

GO:0001933

negative regulation of protein phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P26883
ensembl:ENSMUSP00000037206

P

Seeded From UniProt

complete

enables

GO:0003755

peptidyl-prolyl cis-trans isomerase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:5.2.1.8

F

Seeded From UniProt

complete

enables

GO:0016853

isomerase activity

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0413

F

Seeded From UniProt

complete

enables

GO:0003755

peptidyl-prolyl cis-trans isomerase activity

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0697

F

Seeded From UniProt

complete

enables

GO:0016853

isomerase activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000413783

F

Seeded From UniProt

complete

involved_in

GO:0055117

regulation of cardiac muscle contraction

PMID:14511757[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 Qi, Y et al. (1998) FK-binding protein is associated with the ryanodine receptor of skeletal muscle in vertebrate animals. J. Biol. Chem. 273 34813-9 PubMed GONUTS page
  2. 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 2.12 2.13 2.14 2.15 2.16 2.17 2.18 2.19 2.20 2.21 2.22 2.23 2.24 2.25 2.26 2.27 2.28 2.29 2.30 2.31 2.32 2.33 2.34 2.35 2.36 2.37 2.38 2.39 2.40 2.41 2.42 2.43 2.44 2.45 2.46 2.47 2.48 2.49 2.50 2.51 Obata, K et al. (2001) Role of FK506-binding protein 12 in development of the chick embryonic heart. Biochem. Biophys. Res. Commun. 283 613-20 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 3.9 Yazawa, S et al. (2003) Gene expression of FK506-binding proteins 12.6 and 12 during chicken development. Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. 136 391-9 PubMed GONUTS page
  4. Jeyakumar, LH et al. (2001) FKBP binding characteristics of cardiac microsomes from diverse vertebrates. Biochem. Biophys. Res. Commun. 281 979-86 PubMed GONUTS page
  5. 5.0 5.1 Zeilhofer, HU et al. (2000) Calcium-dependent inactivation of neuronal calcium channel currents is independent of calcineurin. Neuroscience 95 235-41 PubMed GONUTS page
  6. Yazawa, S et al. (2003) Heart-selective expression of the chicken FK506-binding protein (FKBP) 12.6 gene during embryonic development. Dev. Dyn. 226 33-41 PubMed GONUTS page
  7. 7.0 7.1 7.2 7.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page