CHICK:Q90815

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	CRYPalpha1 (ECO:0000313 with EMBL:AAA64460.1)
Protein Name(s)	Protein-tyrosine phosphatase CRYPalpha1 isoform (ECO:0000313 with EMBL:AAA64460.1)
External Links
UniProt	Q90815
EMBL	L32780
PIR	I50212
RefSeq	NP_990738.1
UniGene	Gga.2657 Gga.42907
PDB	2YD4
PDBsum	2YD4
ProteinModelPortal	Q90815
SMR	Q90815
PaxDb	Q90815
PRIDE	Q90815
GeneID	396375
KEGG	gga:396375
CTD	5802
eggNOG	COG5599
HOGENOM	HOG000010250
HOVERGEN	HBG053758
KO	K06778
PhylomeDB	Q90815
EvolutionaryTrace	Q90815
NextBio	20816417
GO	GO:0004725
Gene3D	2.60.40.10 3.90.190.10
InterPro	IPR003961 IPR007110 IPR013783 IPR013098 IPR003598 IPR029021 IPR000387 IPR016130 IPR000242
Pfam	PF00041 PF07679 PF00102
PRINTS	PR00700
SMART	SM00060 SM00408 SM00194
SUPFAM	SSF49265 SSF52799
PROSITE	PS50853 PS50835 PS00383 PS50056 PS50055

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0030424	axon	PMID:7600997^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0043395	heparan sulfate proteoglycan binding	PMID:11865065^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0008201	heparin binding	PMID:11865065^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0008201	heparin binding	PMID:17178832^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:17178832^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:17178832^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:B0V2N1	C	Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:B0V2N1	F	Seeded From UniProt	complete
involved_in	GO:0061000	negative regulation of dendritic spine development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:B0V2N1	P	Seeded From UniProt	complete
involved_in	GO:0048681	negative regulation of axon regeneration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:B0V2N1	P	Seeded From UniProt	complete
involved_in	GO:0048671	negative regulation of collateral sprouting	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:B0V2N1	P	Seeded From UniProt	complete
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:B0V2N1	P	Seeded From UniProt	complete
involved_in	GO:0030517	negative regulation of axon extension	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:B0V2N1	P	Seeded From UniProt	complete
part_of	GO:0099061	integral component of postsynaptic density membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q64605	C	Seeded From UniProt	complete
part_of	GO:0030285	integral component of synaptic vesicle membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q64605	C	Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000242 InterPro:IPR016130	F	Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000242	P	Seeded From UniProt	complete
involved_in	GO:0016311	dephosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000387 InterPro:IPR016130	P	Seeded From UniProt	complete
enables	GO:0016791	phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000387	F	Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.3.48	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-NUL-9603754 Reactome:R-GGA-2467642	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	Reactome:R-NUL-9603754	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0771 UniProtKB-SubCell:SL-0261	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C	Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0628	C	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0358	F	Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
enables	GO:0004721	phosphoprotein phosphatase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0904	F	Seeded From UniProt	complete
part_of	GO:0030672	synaptic vesicle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0260	C	Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0279	C	Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0197	C	Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0297	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Stoker, AW et al. (1995) Axonal localisation of the CAM-like tyrosine phosphatase CRYP alpha: a signalling molecule of embryonic growth cones. Development 121 1833-44 PubMed GONUTS page
↑ ^2.0 ^2.1 Aricescu, AR et al. (2002) Heparan sulfate proteoglycans are ligands for receptor protein tyrosine phosphatase sigma. Mol. Cell. Biol. 22 1881-92 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Lee, S et al. (2007) Dimerization of protein tyrosine phosphatase sigma governs both ligand binding and isoform specificity. Mol. Cell. Biol. 27 1795-808 PubMed GONUTS page

[PMID:7600997-1] Stoker, AW et al. (1995) Axonal localisation of the CAM-like tyrosine phosphatase CRYP alpha: a signalling molecule of embryonic growth cones. Development 121 1833-44 PubMed GONUTS page

[PMID:11865065-2] 2.0 ^2.1 Aricescu, AR et al. (2002) Heparan sulfate proteoglycans are ligands for receptor protein tyrosine phosphatase sigma. Mol. Cell. Biol. 22 1881-92 PubMed GONUTS page

[PMID:17178832-3] 3.0 ^3.1 ^3.2 Lee, S et al. (2007) Dimerization of protein tyrosine phosphatase sigma governs both ligand binding and isoform specificity. Mol. Cell. Biol. 27 1795-808 PubMed GONUTS page

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CHICK:Q90815

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