CHICK:Q8AV73

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	ghr (ECO:0000313 with EMBL:BAC24980.1)
Protein Name(s)	Ghrelin (ECO:0000313 with EMBL:BAC24980.1) Preproghrelin (ECO:0000313 with EMBL:ABE69159.1) Uncharacterized protein (ECO:0000313 with Ensembl:ENSGALP00000013685)
External Links
UniProt	Q8AV73
EMBL	AADN03006464 AY303688 DQ458767 EU477526 AB075215 AB158617
UniGene	Gga.16
Ensembl	ENSGALT00000013700
GeneTree	ENSGT00390000004064
HOVERGEN	HBG018522
OMA	EIQFNAP
OrthoDB	EOG741Z4K
TreeFam	TF336219
Reactome	REACT_242665 REACT_249636 REACT_250082
PRO	PR:Q8AV73
Proteomes	UP000000539
GO	GO:0030424 GO:0005737 GO:0005615 GO:0030296 GO:0008154 GO:0000187 GO:0008343 GO:0016358 GO:0043066 GO:0042322 GO:0001937 GO:0050728 GO:0032691 GO:0045409 GO:0040013 GO:0042536 GO:0032100 GO:0046010 GO:0051461 GO:0051464 GO:0060124 GO:0051965 GO:0060079 GO:0043627
InterPro	IPR006737 IPR005441
PANTHER	PTHR14122
Pfam	PF04643
PRINTS	PR01624

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0006939	smooth muscle contraction	PMID:19615411^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(UBERON:0007357) part_of:(UBERON:0001155) part_of:(UBERON:0007356)	Seeded From UniProt	complete
enables	GO:0031768	ghrelin receptor binding	PMID:19615411^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0071375	cellular response to peptide hormone stimulus	PMID:19615411^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032099	negative regulation of appetite	PMID:15582733^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000854	positive regulation of corticosterone secretion	PMID:15582733^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:16253250^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0060124	positive regulation of growth hormone secretion	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000364583 RGD:632283 UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000364583 UniProtKB:Q9UBU3	P		Seeded From UniProt	complete
involved_in	GO:0032095	regulation of response to food	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000364583 RGD:632283	P		Seeded From UniProt	complete
enables	GO:0031768	ghrelin receptor binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000364583 RGD:632283 UniProtKB:Q8AV73	F		Seeded From UniProt	complete
enables	GO:0016608	growth hormone-releasing hormone activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000364583 RGD:632283	F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000364583 UniProtKB:Q8AV73 UniProtKB:Q9GKY5 UniProtKB:Q9UBU3	C		Seeded From UniProt	complete
involved_in	GO:0001696	gastric acid secretion	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000364583 RGD:632283	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0016608	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016608	P		Seeded From UniProt	complete
involved_in	GO:0061098	positive regulation of protein tyrosine kinase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0030296	P		Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0060079	C		Seeded From UniProt	complete
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQX0 ensembl:ENSMUSP00000145281	P		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQX0 ensembl:ENSMUSP00000145281	P		Seeded From UniProt	complete
involved_in	GO:0051965	positive regulation of synapse assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQX0 ensembl:ENSMUSP00000145281	P		Seeded From UniProt	complete
involved_in	GO:0046676	negative regulation of insulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQX0 ensembl:ENSMUSP00000145281	P		Seeded From UniProt	complete
involved_in	GO:0040013	negative regulation of locomotion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQX0 ensembl:ENSMUSP00000145281	P		Seeded From UniProt	complete
involved_in	GO:0032100	positive regulation of appetite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQX0 ensembl:ENSMUSP00000145281	P		Seeded From UniProt	complete
involved_in	GO:0016358	dendrite development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQX0 ensembl:ENSMUSP00000145281	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQX0 ensembl:ENSMUSP00000145281	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EQX0 ensembl:ENSMUSP00000145281	C		Seeded From UniProt	complete
involved_in	GO:0060124	positive regulation of growth hormone secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
involved_in	GO:0051965	positive regulation of synapse assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
involved_in	GO:0051464	positive regulation of cortisol secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
involved_in	GO:0051461	positive regulation of corticotropin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
involved_in	GO:0046010	positive regulation of circadian sleep/wake cycle, non-REM sleep	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
involved_in	GO:0045409	negative regulation of interleukin-6 biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
involved_in	GO:0043627	response to estrogen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
involved_in	GO:0042536	negative regulation of tumor necrosis factor biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
involved_in	GO:0042322	negative regulation of circadian sleep/wake cycle, REM sleep	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
involved_in	GO:0032691	negative regulation of interleukin-1 beta production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	C		Seeded From UniProt	complete
enables	GO:0030296	protein tyrosine kinase activator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	F		Seeded From UniProt	complete
involved_in	GO:0016358	dendrite development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
involved_in	GO:0009725	response to hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
involved_in	GO:0008154	actin polymerization or depolymerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	C		Seeded From UniProt	complete
involved_in	GO:0001937	negative regulation of endothelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBU3 ensembl:ENSP00000335074	P		Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006737	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005441 InterPro:IPR006737	C		Seeded From UniProt	complete
enables	GO:0016608	growth hormone-releasing hormone activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005441	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Kitazawa, T et al. (2009) Molecular cloning of growth hormone secretagogue-receptor and effect of quail ghrelin on gastrointestinal motility in Japanese quail. Regul. Pept. 158 132-42 PubMed GONUTS page
↑ ^2.0 ^2.1 Saito, ES et al. (2005) Inhibitory effect of ghrelin on food intake is mediated by the corticotropin-releasing factor system in neonatal chicks. Regul. Pept. 125 201-8 PubMed GONUTS page
↑ Richards, MP et al. (2006) Characterization of turkey and chicken ghrelin genes, and regulation of ghrelin and ghrelin receptor mRNA levels in broiler chickens. Gen. Comp. Endocrinol. 145 298-310 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19615411-1] 1.0 ^1.1 ^1.2 Kitazawa, T et al. (2009) Molecular cloning of growth hormone secretagogue-receptor and effect of quail ghrelin on gastrointestinal motility in Japanese quail. Regul. Pept. 158 132-42 PubMed GONUTS page

[PMID:15582733-2] 2.0 ^2.1 Saito, ES et al. (2005) Inhibitory effect of ghrelin on food intake is mediated by the corticotropin-releasing factor system in neonatal chicks. Regul. Pept. 125 201-8 PubMed GONUTS page

[PMID:16253250-3] Richards, MP et al. (2006) Characterization of turkey and chicken ghrelin genes, and regulation of ghrelin and ghrelin receptor mRNA levels in broiler chickens. Gen. Comp. Endocrinol. 145 298-310 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CHICK:Q8AV73

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