CHICK:Q6J613

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	Ii (ECO:0000313 with EMBL:AAT36346.1) (synonyms: CD74 (ECO:0000313 with Ensembl:ENSGALP00000007299))
Protein Name(s)	Invariant chain isoform p41 (ECO:0000313 with EMBL:AAT36346.1) Uncharacterized protein (ECO:0000313 with Ensembl:ENSGALP00000007299)
External Links
UniProt	Q6J613
EMBL	AADN03006662 AY597054
RefSeq	NP_001001613.1
UniGene	Gga.4414
SMR	Q6J613
MEROPS	I31.002
Ensembl	ENSGALT00000007311
GeneID	414741
KEGG	gga:414741
CTD	972
eggNOG	NOG248215
GeneTree	ENSGT00390000008961
HOVERGEN	HBG004444
KO	K06505
OMA	QCDENGN
OrthoDB	EOG793B8J
PhylomeDB	Q6J613
TreeFam	TF317779
Reactome	REACT_198092
NextBio	20818711
PRO	PR:Q6J613
Proteomes	UP000000539
GO	GO:0005783 GO:0009897 GO:0070062 GO:0005794 GO:0016021 GO:0005764 GO:0035692 GO:0042613 GO:0005771 GO:0035693 GO:0001540 GO:0004896 GO:0019886 GO:0008283 GO:0051085 GO:0006952 GO:0016064 GO:0006886 GO:0035691 GO:0043518 GO:1902166 GO:0002906 GO:0002792 GO:0045581 GO:0045060 GO:0030890 GO:2000343 GO:0001961 GO:0002606 GO:0070374 GO:0048146 GO:0060907 GO:0090023 GO:0050731 GO:0045582 GO:0002830 GO:0045059 GO:0001516 GO:0006461
Gene3D	1.10.870.10 4.10.800.10
InterPro	IPR015386 IPR022339 IPR011988 IPR000716
PANTHER	PTHR14093
Pfam	PF09307 PF08831 PF00086
PIRSF	PIRSF001992
PRINTS	PR01990
SMART	SM00211
SUPFAM	SSF48305 SSF57610
PROSITE	PS51162

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0005737	cytoplasm	PMID:24948007^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0042611	MHC protein complex	PMID:24948007^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0042288	MHC class I protein binding	PMID:24948007^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:U3PTD3	F	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:23370168^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:23370168^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0035718	macrophage migration inhibitory factor binding	PMID:25086294^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:25086294^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:25086294^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04233 ensembl:ENSP00000009530	P	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04233 ensembl:ENSP00000009530	P	Seeded From UniProt	complete
involved_in	GO:0051290	protein heterotetramerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04233 ensembl:ENSP00000009530	P	Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04233 ensembl:ENSP00000009530	P	Seeded From UniProt	complete
involved_in	GO:0048146	positive regulation of fibroblast proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04233 ensembl:ENSP00000009530	P	Seeded From UniProt	complete
involved_in	GO:0046598	positive regulation of viral entry into host cell	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04233 ensembl:ENSP00000009530	P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04233 ensembl:ENSP00000009530	P	Seeded From UniProt	complete
involved_in	GO:0045657	positive regulation of monocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04233 ensembl:ENSP00000009530	P	Seeded From UniProt	complete
enables	GO:0044183	protein folding chaperone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04233 ensembl:ENSP00000009530	F	Seeded From UniProt	complete
involved_in	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04233 ensembl:ENSP00000009530	P	Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04233 ensembl:ENSP00000009530	P	Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04233 ensembl:ENSP00000009530	P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04233 ensembl:ENSP00000009530	P	Seeded From UniProt	complete
enables	GO:0042658	MHC class II protein binding, via antigen binding groove	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04233 ensembl:ENSP00000009530	F	Seeded From UniProt	complete
enables	GO:0042609	CD4 receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04233 ensembl:ENSP00000009530	F	Seeded From UniProt	complete
enables	GO:0035718	macrophage migration inhibitory factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04233 ensembl:ENSP00000009530	F	Seeded From UniProt	complete
part_of	GO:0035692	macrophage migration inhibitory factor receptor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04233 ensembl:ENSP00000009530	C	Seeded From UniProt	complete
involved_in	GO:0033674	positive regulation of kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04233 ensembl:ENSP00000009530	P	Seeded From UniProt	complete
involved_in	GO:0030890	positive regulation of B cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04233 ensembl:ENSP00000009530	P	Seeded From UniProt	complete
enables	GO:0023026	MHC class II protein complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04233 ensembl:ENSP00000009530	F	Seeded From UniProt	complete
enables	GO:0019955	cytokine binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04233 ensembl:ENSP00000009530	F	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04233 ensembl:ENSP00000009530	C	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04233 ensembl:ENSP00000009530	C	Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04233 ensembl:ENSP00000009530	P	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04233 ensembl:ENSP00000009530	P	Seeded From UniProt	complete
part_of	GO:0005773	vacuole	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04233 ensembl:ENSP00000009530	C	Seeded From UniProt	complete
enables	GO:0004896	cytokine receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04233 ensembl:ENSP00000009530	F	Seeded From UniProt	complete
involved_in	GO:0002792	negative regulation of peptide secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04233 ensembl:ENSP00000009530	P	Seeded From UniProt	complete
involved_in	GO:0001961	positive regulation of cytokine-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04233 ensembl:ENSP00000009530	P	Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04233 ensembl:ENSP00000009530	P	Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04233 ensembl:ENSP00000009530	F	Seeded From UniProt	complete
involved_in	GO:0001516	prostaglandin biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04233 ensembl:ENSP00000009530	P	Seeded From UniProt	complete
involved_in	GO:2000343	positive regulation of chemokine (C-X-C motif) ligand 2 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04441 ensembl:ENSMUSP00000095171	P	Seeded From UniProt	complete
involved_in	GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04441 ensembl:ENSMUSP00000095171	P	Seeded From UniProt	complete
involved_in	GO:0090023	positive regulation of neutrophil chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04441 ensembl:ENSMUSP00000095171	P	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04441 ensembl:ENSMUSP00000095171	P	Seeded From UniProt	complete
involved_in	GO:0065003	protein-containing complex assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04441 ensembl:ENSMUSP00000095171	P	Seeded From UniProt	complete
involved_in	GO:0060907	positive regulation of macrophage cytokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04441 ensembl:ENSMUSP00000095171	P	Seeded From UniProt	complete
involved_in	GO:0051085	chaperone cofactor-dependent protein refolding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04441 ensembl:ENSMUSP00000095171	P	Seeded From UniProt	complete
enables	GO:0050998	nitric-oxide synthase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04441 ensembl:ENSMUSP00000095171	F	Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04441 ensembl:ENSMUSP00000095171	P	Seeded From UniProt	complete
involved_in	GO:0045582	positive regulation of T cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04441 ensembl:ENSMUSP00000095171	P	Seeded From UniProt	complete
involved_in	GO:0045581	negative regulation of T cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04441 ensembl:ENSMUSP00000095171	P	Seeded From UniProt	complete
involved_in	GO:0045060	negative thymic T cell selection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04441 ensembl:ENSMUSP00000095171	P	Seeded From UniProt	complete
involved_in	GO:0045059	positive thymic T cell selection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04441 ensembl:ENSMUSP00000095171	P	Seeded From UniProt	complete
involved_in	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04441 ensembl:ENSMUSP00000095171	P	Seeded From UniProt	complete
part_of	GO:0042613	MHC class II protein complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04441 ensembl:ENSMUSP00000095171	C	Seeded From UniProt	complete
enables	GO:0042289	MHC class II protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04441 ensembl:ENSMUSP00000095171	F	Seeded From UniProt	complete
part_of	GO:0035693	NOS2-CD74 complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04441 ensembl:ENSMUSP00000095171	C	Seeded From UniProt	complete
part_of	GO:0035692	macrophage migration inhibitory factor receptor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04441 ensembl:ENSMUSP00000095171	C	Seeded From UniProt	complete
involved_in	GO:0035691	macrophage migration inhibitory factor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04441 ensembl:ENSMUSP00000095171	P	Seeded From UniProt	complete
enables	GO:0019955	cytokine binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04441 ensembl:ENSMUSP00000095171	F	Seeded From UniProt	complete
involved_in	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04441 ensembl:ENSMUSP00000095171	P	Seeded From UniProt	complete
involved_in	GO:0019882	antigen processing and presentation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04441 ensembl:ENSMUSP00000095171	P	Seeded From UniProt	complete
involved_in	GO:0016064	immunoglobulin mediated immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04441 ensembl:ENSMUSP00000095171	P	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04441 ensembl:ENSMUSP00000095171	C	Seeded From UniProt	complete
involved_in	GO:0006952	defense response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04441 ensembl:ENSMUSP00000095171	P	Seeded From UniProt	complete
involved_in	GO:0006886	intracellular protein transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04441 ensembl:ENSMUSP00000095171	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04441 ensembl:ENSMUSP00000095171	C	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04441 ensembl:ENSMUSP00000095171	C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04441 ensembl:ENSMUSP00000095171	C	Seeded From UniProt	complete
part_of	GO:0005771	multivesicular body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04441 ensembl:ENSMUSP00000095171	C	Seeded From UniProt	complete
part_of	GO:0005770	late endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04441 ensembl:ENSMUSP00000095171	C	Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04441 ensembl:ENSMUSP00000095171	C	Seeded From UniProt	complete
enables	GO:0004896	cytokine receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04441 ensembl:ENSMUSP00000095171	F	Seeded From UniProt	complete
involved_in	GO:0002906	negative regulation of mature B cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04441 ensembl:ENSMUSP00000095171	P	Seeded From UniProt	complete
involved_in	GO:0002830	positive regulation of type 2 immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04441 ensembl:ENSMUSP00000095171	P	Seeded From UniProt	complete
involved_in	GO:0002606	positive regulation of dendritic cell antigen processing and presentation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04441 ensembl:ENSMUSP00000095171	P	Seeded From UniProt	complete
involved_in	GO:0001961	positive regulation of cytokine-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04441 ensembl:ENSMUSP00000095171	P	Seeded From UniProt	complete
involved_in	GO:0006886	intracellular protein transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015386	P	Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015386	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015386	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011988 InterPro:IPR022339 InterPro:IPR036613	C	Seeded From UniProt	complete
involved_in	GO:0019882	antigen processing and presentation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011988 InterPro:IPR015386 InterPro:IPR022339	P	Seeded From UniProt	complete
enables	GO:0042289	MHC class II protein binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011988 InterPro:IPR015386 InterPro:IPR022339 InterPro:IPR036613	F	Seeded From UniProt	complete
involved_in	GO:0070206	protein trimerization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR036613	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Chen, F et al. (2014) Allele-dependent association of chicken MHC class I molecules with the invariant chain. Vet. Immunol. Immunopathol. 160 273-80 PubMed GONUTS page
↑ ^2.0 ^2.1 Chen, F et al. (2013) Cross-species association of quail invariant chain with chicken and mouse MHC II molecules. Dev. Comp. Immunol. 40 20-7 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Kim, S et al. (2014) Both host and parasite MIF molecules bind to chicken macrophages via CD74 surface receptor. Dev. Comp. Immunol. 47 319-26 PubMed GONUTS page

[PMID:24948007-1] 1.0 ^1.1 ^1.2 Chen, F et al. (2014) Allele-dependent association of chicken MHC class I molecules with the invariant chain. Vet. Immunol. Immunopathol. 160 273-80 PubMed GONUTS page

[PMID:23370168-2] 2.0 ^2.1 Chen, F et al. (2013) Cross-species association of quail invariant chain with chicken and mouse MHC II molecules. Dev. Comp. Immunol. 40 20-7 PubMed GONUTS page

[PMID:25086294-3] 3.0 ^3.1 ^3.2 Kim, S et al. (2014) Both host and parasite MIF molecules bind to chicken macrophages via CD74 surface receptor. Dev. Comp. Immunol. 47 319-26 PubMed GONUTS page

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CHICK:Q6J613

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