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CHICK:PUR9

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) ATIC (synonyms: PURH)
Protein Name(s) Bifunctional purine biosynthesis protein PURH

Phosphoribosylaminoimidazolecarboxamide formyltransferase 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase AICAR transformylase IMP cyclohydrolase ATIC IMP synthase Inosinicase

External Links
UniProt P31335
EMBL S64492
PIR JQ1281
RefSeq NP_990509.1
UniGene Gga.4556
PDB 1G8M
1M9N
1OZ0
1THZ
2B1G
2B1I
2IU0
2IU3
PDBsum 1G8M
1M9N
1OZ0
1THZ
2B1G
2B1I
2IU0
2IU3
ProteinModelPortal P31335
SMR P31335
PaxDb P31335
PRIDE P31335
GeneID 396091
KEGG gga:396091
CTD 471
eggNOG COG0138
HOGENOM HOG000230372
HOVERGEN HBG006912
InParanoid P31335
KO K00602
PhylomeDB P31335
Reactome REACT_116007
UniPathway UPA00074
UPA00074
EvolutionaryTrace P31335
NextBio 20816149
PRO PR:P31335
Proteomes UP000000539
GO GO:0005829
GO:0003937
GO:0004643
GO:0042803
GO:0006189
GO:0055086
GO:0006144
GO:0044281
Gene3D 1.10.287.440
3.40.140.20
3.40.50.1380
HAMAP MF_00139
InterPro IPR024051
IPR024050
IPR002695
IPR016193
IPR011607
PANTHER PTHR11692
Pfam PF01808
PF02142
PIRSF PIRSF000414
SMART SM00798
SM00851
SUPFAM SSF52335
SSF53927
TIGRFAMs TIGR00355

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0042803

protein homodimerization activity

PMID:11323713[1]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P31335

F

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016193

F

Seeded From UniProt

complete

enables

GO:0003937

IMP cyclohydrolase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002695

F

Seeded From UniProt

complete

enables

GO:0004643

phosphoribosylaminoimidazolecarboxamide formyltransferase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002695

F

Seeded From UniProt

complete

involved_in

GO:0006164

purine nucleotide biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002695

P

Seeded From UniProt

complete

enables

GO:0003937

IMP cyclohydrolase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.5.4.10

F

Seeded From UniProt

complete

enables

GO:0004643

phosphoribosylaminoimidazolecarboxamide formyltransferase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.1.2.3

F

Seeded From UniProt

complete

involved_in

GO:0006189

'de novo' IMP biosynthetic process

Reactome:R-GGA-419140

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-GGA-419254
Reactome:R-GGA-419253

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

involved_in

GO:0006164

purine nucleotide biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0658

P

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0511

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

involved_in

GO:0008152

metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0511

P

Seeded From UniProt

complete

involved_in

GO:0006189

'de novo' IMP biosynthetic process

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00074

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Greasley, SE et al. (2001) Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis. Nat. Struct. Biol. 8 402-6 PubMed GONUTS page