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CHICK:PTN

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) PTN
Protein Name(s) Pleiotrophin

PTN Heparin-binding brain mitogen HBBM Heparin-binding growth factor 8 HBGF-8 Heparin-binding growth-associated molecule HB-GAM Heparin-binding neutrophic factor HBNF Osteoblast-specific factor 1 OSF-1

External Links
UniProt P32760
PIR B60042
UniGene Gga.39450
ProteinModelPortal P32760
STRING 9031.ENSGALP00000036778
eggNOG NOG262747
HOGENOM HOG000231473
HOVERGEN HBG008317
InParanoid P32760
PhylomeDB P32760
PRO PR:P32760
Proteomes UP000000539
GO GO:0005576
GO:0008201
GO:0051781
Gene3D 2.20.60.10
2.30.90.10
InterPro IPR000762
IPR020090
IPR020091
IPR020089
IPR020092
PANTHER PTHR13850
Pfam PF01091
PF05196
PRINTS PR00269
ProDom PD005592
SMART SM00193
SUPFAM SSF57288
PROSITE PS00619
PS00620

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0030282

bone mineralization

PMID:19526365[1]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P63089

P

Seeded From UniProt

complete

involved_in

GO:0007612

learning

PMID:19526365[1]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P63089

P

Seeded From UniProt

complete

involved_in

GO:0001503

ossification

PMID:19526365[1]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P63089

P

Seeded From UniProt

complete

involved_in

GO:0061056

sclerotome development

PMID:19526365[1]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0061054

dermatome development

PMID:19526365[1]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060173

limb development

PMID:19526365[1]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051216

cartilage development

PMID:19526365[1]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043588

skin development

PMID:19526365[1]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0021915

neural tube development

PMID:19526365[1]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007507

heart development

PMID:19526365[1]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007420

brain development

PMID:19526365[1]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001756

somitogenesis

PMID:19526365[1]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008083

growth factor activity

PMID:1550956[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21246

C

Seeded From UniProt

complete

enables

GO:0008201

heparin binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21246

F

Seeded From UniProt

complete

enables

GO:0008083

growth factor activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21246

F

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21246

P

Seeded From UniProt

complete

enables

GO:0035374

chondroitin sulfate binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21246

F

Seeded From UniProt

complete

involved_in

GO:0035989

tendon development

PMID:19526365[1]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008083

growth factor activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000354681
RGD:3444
UniProtKB:P21246
UniProtKB:P32760
ZFIN:ZDB-GENE-030624-1

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001015086
RGD:3444

C

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0008083

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0008083

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0008083

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0008083

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0008083

P

Seeded From UniProt

complete

enables

GO:0008083

growth factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000762
InterPro:IPR020089
InterPro:IPR020090
InterPro:IPR020091
InterPro:IPR020092
InterPro:IPR037122

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

enables

GO:0008083

growth factor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0339

F

Seeded From UniProt

complete

involved_in

GO:0051781

positive regulation of cell division

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0497

P

Seeded From UniProt

complete

enables

GO:0008201

heparin binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0358

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 Mittapalli, VR et al. (2009) Pleiotrophin is expressed in avian somites and tendon anlagen. Histochem. Cell Biol. 132 413-22 PubMed GONUTS page
  2. Hampton, BS et al. (1992) Structural and functional characterization of full-length heparin-binding growth associated molecule. Mol. Biol. Cell 3 85-93 PubMed GONUTS page
  3. 3.0 3.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page