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CHICK:PRL

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) PRL
Protein Name(s) Prolactin

PRL

External Links
UniProt P14676
EMBL J04614
AB011438
AF288765
AY588297
AY588296
AY588295
AY588294
AY588304
AY588301
AY588302
AY588303
AY588311
AY588308
AY588309
AY588310
AY588318
AY588316
AY588317
AY588315
PIR A60972
RefSeq NP_990797.2
UniGene Gga.1802
ProteinModelPortal P14676
SMR P14676
Ensembl ENSGALT00000020680
GeneID 396453
KEGG gga:396453
CTD 5617
eggNOG NOG47376
GeneTree ENSGT00730000110805
HOGENOM HOG000264241
HOVERGEN HBG104895
InParanoid P14676
KO K05439
OMA LHCLRRD
OrthoDB EOG74FF24
PhylomeDB P14676
TreeFam TF332592
Reactome REACT_197049
REACT_197052
REACT_197455
NextBio 20816494
PRO PR:P14676
Proteomes UP000000539
ExpressionAtlas P14676
GO GO:0005615
GO:0033685
GO:0046427
GO:0040014
Gene3D 1.20.1250.10
InterPro IPR009079
IPR012351
IPR001400
IPR018116
PANTHER PTHR11417
Pfam PF00103
PRINTS PR00836
SUPFAM SSF47266
PROSITE PS00266
PS00338

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005615

extracellular space

PMID:17045993[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0046427

positive regulation of receptor signaling pathway via JAK-STAT

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97762
PANTHER:PTN000151829
UniProtKB:P01236
UniProtKB:P01241

P

Seeded From UniProt

complete

involved_in

GO:0031667

response to nutrient levels

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000151829
UniProtKB:P01246

P

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1341833
MGI:MGI:97762
PANTHER:PTN000151831
RGD:2428
RGD:3403

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1341833
MGI:MGI:1858413
MGI:MGI:95707
MGI:MGI:97606
MGI:MGI:97607
MGI:MGI:97618
MGI:MGI:97619
PANTHER:PTN000151829
RGD:2429
RGD:2686
UniProtKB:P01238
UniProtKB:P01239
UniProtKB:P01241
UniProtKB:P01246
UniProtKB:P08998
UniProtKB:P14676

C

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1341833
MGI:MGI:97618
MGI:MGI:97619
PANTHER:PTN000151829
RGD:2686

F

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

involved_in

GO:1902895

positive regulation of pri-miRNA transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01236
ensembl:ENSP00000302150

P

Seeded From UniProt

complete

involved_in

GO:0046427

positive regulation of receptor signaling pathway via JAK-STAT

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01236
ensembl:ENSP00000302150

P

Seeded From UniProt

complete

involved_in

GO:0040014

regulation of multicellular organism growth

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01236
ensembl:ENSP00000302150

P

Seeded From UniProt

complete

involved_in

GO:0001937

negative regulation of endothelial cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01236
ensembl:ENSP00000302150

P

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001400
InterPro:IPR018116

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001400
InterPro:IPR018116

C

Seeded From UniProt

complete

involved_in

GO:0033685

negative regulation of luteinizing hormone secretion

PMID:7772235[3]
PMID:12535623[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:9845667[5]
PMID:8902221[6]
PMID:7772235[3]
PMID:19540238[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0372

F

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Leclerc, B et al. (2007) Development of a real-time (Q) PCR assay to measure variation in expression of prolactin receptor mRNA in the hypothalamus and pituitary gland during late embryogenesis in turkeys and chickens. Gen. Comp. Endocrinol. 150 319-25 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. ↑ 3.0 3.1 You, S et al. (1995) Sequence analysis of the turkey LH beta subunit and its regulation by gonadotrophin-releasing hormone and prolactin in cultured pituitary cells. J. Mol. Endocrinol. 14 117-29 PubMed GONUTS page
  4. ↑ Bhatt, R et al. (2003) Dopamine infusion into the third ventricle increases gene expression of hypothalamic vasoactive intestinal peptide and pituitary prolactin and luteinizing hormone beta subunit in the turkey. Gen. Comp. Endocrinol. 130 41-7 PubMed GONUTS page
  5. ↑ Tong, Z et al. (1998) Vasoactive intestinal peptide stimulates turkey prolactin gene expression by increasing transcription rate and enhancing mRNA stability. J. Mol. Endocrinol. 21 259-66 PubMed GONUTS page
  6. ↑ Zhou, JF et al. (1996) Molecular cloning, tissue distribution, and expression of the prolactin receptor during various reproductive states in Meleagris gallopavo. Biol. Reprod. 55 1081-90 PubMed GONUTS page
  7. ↑ Chaiseha, Y et al. (2010) Serotonin receptor subtypes influence prolactin secretion in the turkey. Gen. Comp. Endocrinol. 165 170-5 PubMed GONUTS page
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