GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

CHICK:NTRK3

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) NTRK3 (synonyms: TRKC)
Protein Name(s) NT-3 growth factor receptor

Neurotrophic tyrosine kinase receptor type 3 TrkC tyrosine kinase Trk-C

External Links
UniProt Q91044
EMBL S74248
X59669
Z30091
PIR I51222
I51259
S35695
RefSeq NP_990500.1
UniGene Gga.509
PDB 4PBV
4PBW
PDBsum 4PBV
4PBW
ProteinModelPortal Q91044
SMR Q91044
MINT MINT-127882
STRING 9031.ENSGALP00000010970
MEROPS I43.001
PaxDb Q91044
GeneID 396081
KEGG gga:396081
CTD 4916
eggNOG COG0515
HOVERGEN HBG056735
InParanoid Q91044
KO K05101
PhylomeDB Q91044
BRENDA 2.7.10.1
NextBio 20816139
PRO PR:Q91044
Proteomes UP000000539
GO GO:0005887
GO:0005524
GO:0005030
GO:0004714
GO:0030154
GO:0007399
GO:0007169
Gene3D 2.60.40.10
InterPro IPR000483
IPR007110
IPR013783
IPR013098
IPR003599
IPR011009
IPR001611
IPR000372
IPR000719
IPR017441
IPR001245
IPR020446
IPR008266
IPR020635
IPR020777
IPR002011
Pfam PF07679
PF13855
PF07714
PRINTS PR01939
PR01942
PR00109
SMART SM00409
SM00082
SM00013
SM00219
SUPFAM SSF56112
PROSITE PS50835
PS51450
PS00107
PS50011
PS00109
PS00239

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0007507

heart development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q16288

P

Seeded From UniProt

complete

involved_in

GO:1990090

cellular response to nerve growth factor stimulus

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97383
PANTHER:PTN001230900
RGD:3213
RGD:620144
UniProtKB:P04629

P

Seeded From UniProt

complete

NOT|involved_in

GO:0070374

positive regulation of ERK1 and ERK2 cascade

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002400475
UniProtKB:P04629

P

Seeded From UniProt

complete

involved_in

GO:0043410

positive regulation of MAPK cascade

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002400475
RGD:3213
UniProtKB:Q16288

P

Seeded From UniProt

complete

involved_in

GO:0043408

regulation of MAPK cascade

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002400475
RGD:3213
UniProtKB:Q16288

P

Seeded From UniProt

complete

part_of

GO:0043235

receptor complex

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0015380
FB:FBgn0024245
FB:FBgn0033791
PANTHER:PTN002356460
UniProtKB:A6QR62
UniProtKB:O15146
UniProtKB:P00533
UniProtKB:P04626
UniProtKB:P04629
UniProtKB:P06213
UniProtKB:P07949
UniProtKB:P08069
UniProtKB:P11362
UniProtKB:P14616
UniProtKB:P17948
UniProtKB:P21860
UniProtKB:P35916
UniProtKB:Q01973
UniProtKB:Q08345
UniProtKB:Q15303
UniProtKB:Q16288
UniProtKB:Q16620

C

Seeded From UniProt

complete

enables

GO:0043121

neurotrophin binding

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97384
PANTHER:PTN001230900
RGD:3213
UniProtKB:Q16620

F

Seeded From UniProt

complete

part_of

GO:0030424

axon

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97383
PANTHER:PTN001230900
RGD:3213
RGD:620144

C

Seeded From UniProt

complete

involved_in

GO:0014068

positive regulation of phosphatidylinositol 3-kinase signaling

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002400475
RGD:3213

P

Seeded From UniProt

complete

involved_in

GO:0010976

positive regulation of neuron projection development

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97384
MGI:MGI:97385
PANTHER:PTN002400475
RGD:3213
RGD:3214
UniProtKB:Q91987

P

Seeded From UniProt

complete

involved_in

GO:0007399

nervous system development

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97383
MGI:MGI:97384
MGI:MGI:97385
PANTHER:PTN002400475
RGD:3213
RGD:3214
RGD:620144
UniProtKB:P04629
UniProtKB:Q91987
ZFIN:ZDB-GENE-010126-3

P

Seeded From UniProt

complete

involved_in

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003366
FB:FBgn0003731
FB:FBgn0003733
FB:FBgn0283499
MGI:MGI:104757
MGI:MGI:109378
MGI:MGI:1096337
MGI:MGI:1339758
MGI:MGI:1345277
MGI:MGI:95276
MGI:MGI:95278
MGI:MGI:95294
MGI:MGI:95522
MGI:MGI:95523
MGI:MGI:95524
MGI:MGI:95525
MGI:MGI:95558
MGI:MGI:95561
MGI:MGI:96575
MGI:MGI:96677
MGI:MGI:96683
MGI:MGI:96969
MGI:MGI:97384
MGI:MGI:97530
MGI:MGI:97531
MGI:MGI:97902
MGI:MGI:98277
MGI:MGI:99216
MGI:MGI:99611
MGI:MGI:99612
MGI:MGI:99654
PANTHER:PTN002356460
RGD:2543
RGD:2611
RGD:2612
RGD:2621
RGD:2869
RGD:2917
RGD:2965
RGD:3082
RGD:3213
RGD:3214
RGD:3284
RGD:3285
RGD:620144
RGD:620714
RGD:620831
RGD:621737
RGD:69323
UniProtKB:A6QR62
UniProtKB:P00533
UniProtKB:P04626
UniProtKB:P04629
UniProtKB:P06213
UniProtKB:P07949
UniProtKB:P08069
UniProtKB:P09619
UniProtKB:P10721
UniProtKB:P11362
UniProtKB:P16234
UniProtKB:P17948
UniProtKB:P21709
UniProtKB:P21802
UniProtKB:P22455
UniProtKB:P22607
UniProtKB:P29317
UniProtKB:P29320
UniProtKB:P35916
UniProtKB:P35968
UniProtKB:P54753
UniProtKB:P54760
UniProtKB:P54762
UniProtKB:P54764
UniProtKB:Q02763
UniProtKB:Q08345
UniProtKB:Q15303
UniProtKB:Q15375
UniProtKB:Q16288
UniProtKB:Q16620
UniProtKB:Q16832
UniProtKB:Q5JZY3
UniProtKB:Q91987
WB:WBGene00001184
WB:WBGene00006868
ZFIN:ZDB-GENE-020503-1
ZFIN:ZDB-GENE-020503-2
ZFIN:ZDB-GENE-060503-14
ZFIN:ZDB-GENE-070713-2
ZFIN:ZDB-GENE-980526-255
ZFIN:ZDB-GENE-980526-326
ZFIN:ZDB-GENE-990415-62

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003366
FB:FBgn0003731
FB:FBgn0003733
FB:FBgn0011829
FB:FBgn0015380
FB:FBgn0032006
FB:FBgn0283499
MGI:MGI:103581
MGI:MGI:104771
MGI:MGI:109378
MGI:MGI:98277
MGI:MGI:99611
PANTHER:PTN002356460
RGD:1560587
RGD:3213
RGD:3214
RGD:70957
UniProtKB:P04629
UniProtKB:P06213
UniProtKB:P07949
UniProtKB:P16234
UniProtKB:P17948
UniProtKB:P21709
UniProtKB:P21802
UniProtKB:P22455
UniProtKB:P22607
UniProtKB:P29317
UniProtKB:P29320
UniProtKB:P35968
UniProtKB:P54753
UniProtKB:P54760
UniProtKB:P54762
UniProtKB:Q02763
UniProtKB:Q16620
UniProtKB:Q9UM73
WB:WBGene00000289
WB:WBGene00000898

C

Seeded From UniProt

complete

enables

GO:0005030

neurotrophin receptor activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001230900
RGD:3213
UniProtKB:Q16288

F

Seeded From UniProt

complete

enables

GO:0004714

transmembrane receptor protein tyrosine kinase activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003733
FB:FBgn0040505
FB:FBgn0283499
MGI:MGI:109378
MGI:MGI:1339758
MGI:MGI:1345277
MGI:MGI:95276
MGI:MGI:95294
MGI:MGI:95522
MGI:MGI:95524
MGI:MGI:95558
MGI:MGI:95561
MGI:MGI:96677
MGI:MGI:96683
MGI:MGI:96969
MGI:MGI:97384
MGI:MGI:97530
MGI:MGI:97902
MGI:MGI:98277
MGI:MGI:99611
MGI:MGI:99612
MGI:MGI:99654
PANTHER:PTN002356460
RGD:2543
RGD:2611
RGD:2621
RGD:2869
RGD:2917
RGD:2965
RGD:3082
RGD:3213
RGD:3214
RGD:3284
RGD:3285
RGD:620144
RGD:620714
RGD:620831
RGD:621737
UniProtKB:P00533
UniProtKB:P04626
UniProtKB:P04629
UniProtKB:P06213
UniProtKB:P07333
UniProtKB:P07949
UniProtKB:P08069
UniProtKB:P09619
UniProtKB:P10721
UniProtKB:P11362
UniProtKB:P14616
UniProtKB:P16234
UniProtKB:P17948
UniProtKB:P21709
UniProtKB:P21802
UniProtKB:P22455
UniProtKB:P22607
UniProtKB:P29317
UniProtKB:P29320
UniProtKB:P35916
UniProtKB:P35968
UniProtKB:P54753
UniProtKB:P54760
UniProtKB:P54762
UniProtKB:Q08345
UniProtKB:Q15303
UniProtKB:Q16620
UniProtKB:Q16832
UniProtKB:Q5JZY3
UniProtKB:Q91987
UniProtKB:Q9UM73
WB:WBGene00000289
WB:WBGene00006868
WB:WBGene00020504
ZFIN:ZDB-GENE-980526-255

F

Seeded From UniProt

complete

involved_in

GO:0018108

peptidyl-tyrosine phosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004714

P

Seeded From UniProt

complete

involved_in

GO:0018108

peptidyl-tyrosine phosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004713

P

Seeded From UniProt

complete

involved_in

GO:0018108

peptidyl-tyrosine phosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004714

P

Seeded From UniProt

complete

involved_in

GO:0018108

peptidyl-tyrosine phosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004713

P

Seeded From UniProt

complete

involved_in

GO:0018108

peptidyl-tyrosine phosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004714

P

Seeded From UniProt

complete

involved_in

GO:0038179

neurotrophin signaling pathway

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005030

P

Seeded From UniProt

complete

involved_in

GO:0038179

neurotrophin signaling pathway

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005030

P

Seeded From UniProt

complete

involved_in

GO:0038179

neurotrophin signaling pathway

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005030

P

Seeded From UniProt

complete

involved_in

GO:2000251

positive regulation of actin cytoskeleton reorganization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q16288
ensembl:ENSP00000354207

P

Seeded From UniProt

complete

involved_in

GO:0090630

activation of GTPase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q16288
ensembl:ENSP00000354207

P

Seeded From UniProt

complete

involved_in

GO:0050927

positive regulation of positive chemotaxis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q16288
ensembl:ENSP00000354207

P

Seeded From UniProt

complete

part_of

GO:0043235

receptor complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q16288
ensembl:ENSP00000354207

C

Seeded From UniProt

complete

involved_in

GO:0033138

positive regulation of peptidyl-serine phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q16288
ensembl:ENSP00000354207

P

Seeded From UniProt

complete

involved_in

GO:0032148

activation of protein kinase B activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q16288
ensembl:ENSP00000354207

P

Seeded From UniProt

complete

involved_in

GO:0030335

positive regulation of cell migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q16288
ensembl:ENSP00000354207

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q16288
ensembl:ENSP00000354207

P

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q16288
ensembl:ENSP00000354207

P

Seeded From UniProt

complete

involved_in

GO:0007507

heart development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q16288
ensembl:ENSP00000354207

P

Seeded From UniProt

complete

involved_in

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q16288
ensembl:ENSP00000354207

P

Seeded From UniProt

complete

enables

GO:0005030

neurotrophin receptor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q16288
ensembl:ENSP00000354207

F

Seeded From UniProt

complete

enables

GO:0002039

p53 binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q16288
ensembl:ENSP00000354207

F

Seeded From UniProt

complete

involved_in

GO:0001933

negative regulation of protein phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q16288
ensembl:ENSP00000354207

P

Seeded From UniProt

complete

involved_in

GO:0000187

activation of MAPK activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q16288
ensembl:ENSP00000354207

P

Seeded From UniProt

complete

involved_in

GO:0070306

lens fiber cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6VNS1
ensembl:ENSMUSP00000037909

P

Seeded From UniProt

complete

involved_in

GO:0051965

positive regulation of synapse assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6VNS1
ensembl:ENSMUSP00000037909

P

Seeded From UniProt

complete

involved_in

GO:0048691

positive regulation of axon extension involved in regeneration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6VNS1
ensembl:ENSMUSP00000037909

P

Seeded From UniProt

complete

involved_in

GO:0043065

positive regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6VNS1
ensembl:ENSMUSP00000037909

P

Seeded From UniProt

complete

involved_in

GO:0042490

mechanoreceptor differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6VNS1
ensembl:ENSMUSP00000037909

P

Seeded From UniProt

complete

involved_in

GO:0022011

myelination in peripheral nervous system

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6VNS1
ensembl:ENSMUSP00000037909

P

Seeded From UniProt

complete

involved_in

GO:0019227

neuronal action potential propagation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6VNS1
ensembl:ENSMUSP00000037909

P

Seeded From UniProt

complete

involved_in

GO:0007623

circadian rhythm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6VNS1
ensembl:ENSMUSP00000037909

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6VNS1
ensembl:ENSMUSP00000037909

C

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR001245
InterPro:IPR008266

F

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR020635

F

Seeded From UniProt

complete

enables

GO:0004714

transmembrane receptor protein tyrosine kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002011
InterPro:IPR020446
InterPro:IPR020777

F

Seeded From UniProt

complete

enables

GO:0005030

neurotrophin receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR020446

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR002011
InterPro:IPR017441
InterPro:IPR020777

F

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR020446
InterPro:IPR020777

C

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR001245
InterPro:IPR002011
InterPro:IPR008266
InterPro:IPR020446
InterPro:IPR020635
InterPro:IPR020777

P

Seeded From UniProt

complete

involved_in

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002011
InterPro:IPR020446
InterPro:IPR020777

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002011

C

Seeded From UniProt

complete

enables

GO:0004714

transmembrane receptor protein tyrosine kinase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.10.1

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472
UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0829

F

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

involved_in

GO:0007399

nervous system development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0524

P

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page