CHICK:NEUS

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	SERPINI1 (synonyms: PI12)
Protein Name(s)	Neuroserpin Axonin-2 Peptidase inhibitor 12 PI-12 Serpin I1
External Links
UniProt	Q90935
EMBL	Z71930
PIR	S70647
RefSeq	NP_001004411.1
UniGene	Gga.4416
ProteinModelPortal	Q90935
SMR	Q90935
STRING	9031.ENSGALP00000015400
MEROPS	I04.025
PaxDb	Q90935
Ensembl	ENSGALT00000015416
GeneID	425002
KEGG	gga:425002
CTD	5274
eggNOG	COG4826
GeneTree	ENSGT00760000118839
HOGENOM	HOG000238519
HOVERGEN	HBG005957
InParanoid	Q90935
OMA	TEESHYV
OrthoDB	EOG7327PB
PhylomeDB	Q90935
TreeFam	TF352620
NextBio	20827255
PRO	PR:Q90935
Proteomes	UP000000539
GO	GO:0005615 GO:0070062 GO:0004867 GO:0010951 GO:0030162
InterPro	IPR023795 IPR023796 IPR000215
PANTHER	PTHR11461
Pfam	PF00079
SMART	SM00093
SUPFAM	SSF56574
PROSITE	PS00284

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0060205	cytoplasmic vesicle lumen	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99574	C	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99574	C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:8670795^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:9442076^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004867	serine-type endopeptidase inhibitor activity	PMID:9442076^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0010951	negative regulation of endopeptidase activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0028988 FB:FBgn0265137 PANTHER:PTN000156123 RGD:3249 UniProtKB:P05121 UniProtKB:P29508 UniProtKB:P35237 UniProtKB:P50452 UniProtKB:P50453 UniProtKB:Q9UIV8	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0002930 FB:FBgn0015586 FB:FBgn0028986 FB:FBgn0031973 FB:FBgn0262057 FB:FBgn0265137 MGI:MGI:108080 MGI:MGI:1915304 MGI:MGI:87963 MGI:MGI:88278 MGI:MGI:894696 PANTHER:PTN000156123 RGD:1306692 RGD:1307404 RGD:2069 RGD:3249 RGD:3326 RGD:3747 RGD:3748 RGD:619833 RGD:631369 RGD:735225 UniProtKB:P01008 UniProtKB:P01009 UniProtKB:P01011 UniProtKB:P01019 UniProtKB:P05121 UniProtKB:P05154 UniProtKB:P08697 UniProtKB:P50453 UniProtKB:Q90935 UniProtKB:Q99574 UniProtKB:Q9TTE1	C	Seeded From UniProt	complete
enables	GO:0004867	serine-type endopeptidase inhibitor activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0002930 FB:FBgn0028983 FB:FBgn0028988 FB:FBgn0028990 FB:FBgn0265137 MGI:MGI:101780 MGI:MGI:106603 MGI:MGI:1277952 MGI:MGI:2445361 MGI:MGI:2683293 MGI:MGI:891970 MGI:MGI:894696 MGI:MGI:97608 PANTHER:PTN000156123 RGD:1306692 RGD:1307404 RGD:3249 RGD:3326 RGD:3748 RGD:619817 RGD:619896 RGD:619897 UniProtKB:P01009 UniProtKB:P01012 UniProtKB:P05121 UniProtKB:P05154 UniProtKB:P05155 UniProtKB:P07093 UniProtKB:P08697 UniProtKB:P35237 UniProtKB:P48594 UniProtKB:P50452 UniProtKB:P50453 UniProtKB:Q3ZEJ6 UniProtKB:Q86WD7 UniProtKB:Q90935 UniProtKB:Q96P63 UniProtKB:Q99574 UniProtKB:Q9TTE1 UniProtKB:Q9UIV8 WB:WBGene00005643	F	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35684 ensembl:ENSMUSP00000029423	C	Seeded From UniProt	complete
part_of	GO:0034774	secretory granule lumen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35684 ensembl:ENSMUSP00000029423	C	Seeded From UniProt	complete
part_of	GO:0060205	cytoplasmic vesicle lumen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99574 ensembl:ENSP00000295777	C	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99574 ensembl:ENSP00000295777	C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99574 ensembl:ENSP00000295777	C	Seeded From UniProt	complete
enables	GO:0004867	serine-type endopeptidase inhibitor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99574 ensembl:ENSP00000295777	F	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000215	C	Seeded From UniProt	complete
enables	GO:0030414	peptidase inhibitor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0646	F	Seeded From UniProt	complete
enables	GO:0004867	serine-type endopeptidase inhibitor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0722	F	Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
involved_in	GO:0010466	negative regulation of peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0646	P	Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0197	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Osterwalder, T et al. (1996) Neuroserpin, an axonally secreted serine protease inhibitor. EMBO J. 15 2944-53 PubMed GONUTS page
↑ ^2.0 ^2.1 Osterwalder, T et al. (1998) The axonally secreted serine proteinase inhibitor, neuroserpin, inhibits plasminogen activators and plasmin but not thrombin. J. Biol. Chem. 273 2312-21 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:8670795-1] Osterwalder, T et al. (1996) Neuroserpin, an axonally secreted serine protease inhibitor. EMBO J. 15 2944-53 PubMed GONUTS page

[PMID:9442076-2] 2.0 ^2.1 Osterwalder, T et al. (1998) The axonally secreted serine proteinase inhibitor, neuroserpin, inhibits plasminogen activators and plasmin but not thrombin. J. Biol. Chem. 273 2312-21 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CHICK:NEUS

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