CHICK:MTDC

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	MTHFD2
Protein Name(s)	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial NAD-dependent methylenetetrahydrofolate dehydrogenase Methenyltetrahydrofolate cyclohydrolase
External Links
UniProt	Q5ZKA5
EMBL	AJ720179
RefSeq	NP_001026531.1
UniGene	Gga.2672
ProteinModelPortal	Q5ZKA5
BioGrid	685886
STRING	9031.ENSGALP00000022034
PaxDb	Q5ZKA5
GeneID	426126
KEGG	gga:426126
CTD	10797
eggNOG	COG0190
HOGENOM	HOG000218242
HOVERGEN	HBG006411
InParanoid	Q5ZKA5
KO	K13403
PhylomeDB	Q5ZKA5
NextBio	20827831
PRO	PR:Q5ZKA5
Proteomes	UP000000539
GO	GO:0005739 GO:0004477 GO:0004487 GO:0004488 GO:0009396 GO:0006730
Gene3D	3.40.50.720
HAMAP	MF_01576
InterPro	IPR016040 IPR000672 IPR020630 IPR020867 IPR020631
Pfam	PF00763 PF02882
PRINTS	PR00085
PROSITE	PS00766 PS00767

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0042301	phosphate ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P13995	F		Seeded From UniProt	complete
enables	GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P13995	F		Seeded From UniProt	complete
enables	GO:0004487	methylenetetrahydrofolate dehydrogenase (NAD+) activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P13995	F		Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P13995	F		Seeded From UniProt	complete
involved_in	GO:0046653	tetrahydrofolate metabolic process		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000002250 TAIR:locus:2082254 UniProtKB:P13995	P		Seeded From UniProt	complete
involved_in	GO:0035999	tetrahydrofolate interconversion		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000002250 RGD:1310879	P		Seeded From UniProt	complete
enables	GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000002250 RGD:1310879 UniProtKB:P13995	F		Seeded From UniProt	complete
enables	GO:0004487	methylenetetrahydrofolate dehydrogenase (NAD+) activity		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000002329 UniProtKB:P13995	F		Seeded From UniProt	complete
enables	GO:0004477	methenyltetrahydrofolate cyclohydrolase activity		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10328 PANTHER:PTN000002250	F		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020867	F		Seeded From UniProt	complete
enables	GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000672 InterPro:IPR020630 InterPro:IPR020631	F		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000672 InterPro:IPR020630 InterPro:IPR020867	P		Seeded From UniProt	complete
enables	GO:0004477	methenyltetrahydrofolate cyclohydrolase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.5.4.9	F		Seeded From UniProt	complete
enables	GO:0004487	methylenetetrahydrofolate dehydrogenase (NAD+) activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.5.1.15	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
involved_in	GO:0006730	one-carbon metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0554	P		Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	P		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	F		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496 UniProtKB-SubCell:SL-0173	C		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
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References

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