CHICK:LEP

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	LEP (synonyms: OB)
Protein Name(s)	Leptin Obesity factor
External Links
UniProt	O42164
EMBL	AF012727 AF082500
ProteinModelPortal	O42164
SMR	O42164
HOVERGEN	HBG007860
InParanoid	O42164
PhylomeDB	O42164
Proteomes	UP000000539
GO	GO:0005576 GO:0007165
Gene3D	1.20.1250.10
InterPro	IPR009079 IPR012351 IPR000065
PANTHER	PTHR11724
Pfam	PF02024
PIRSF	PIRSF001837
PRINTS	PR00495
ProDom	PD005698
SUPFAM	SSF47266

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0032760	positive regulation of tumor necrosis factor production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41160	P		Seeded From UniProt	complete
involved_in	GO:0032635	interleukin-6 production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41160	P		Seeded From UniProt	complete
involved_in	GO:0032615	interleukin-12 production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41160	P		Seeded From UniProt	complete
involved_in	GO:0044320	cellular response to leptin stimulus	PMID:15907812^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0001898)	Seeded From UniProt	complete
involved_in	GO:0006909	phagocytosis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41160	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:16303278^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0001305)	Seeded From UniProt	complete
involved_in	GO:2000866	positive regulation of estradiol secretion	PMID:16303278^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000872	positive regulation of progesterone secretion	PMID:16303278^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033686	positive regulation of luteinizing hormone secretion	PMID:16303278^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000196	positive regulation of female gonad development	PMID:16303278^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000866	positive regulation of estradiol secretion	PMID:14748693^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	happens_during:(GO:0042594) occurs_in:(UBERON:0000992)	Seeded From UniProt	complete
involved_in	GO:2000872	positive regulation of progesterone secretion	PMID:14748693^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	happens_during:(GO:0042594) occurs_in:(UBERON:0000992)	Seeded From UniProt	complete
involved_in	GO:0033686	positive regulation of luteinizing hormone secretion	PMID:14748693^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	happens_during:(GO:0042594)	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:14748693^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0001305)	Seeded From UniProt	complete
involved_in	GO:0001552	ovarian follicle atresia	PMID:14748693^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032099	negative regulation of appetite	PMID:14748693^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:15907812^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0001898)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:15907812^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0032099	negative regulation of appetite	PMID:15907812^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1990051	activation of protein kinase C activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001711963 UniProtKB:P41159	P		Seeded From UniProt	complete
involved_in	GO:1900745	positive regulation of p38MAPK cascade	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001711963 UniProtKB:P41159	P		Seeded From UniProt	complete
enables	GO:0051428	peptide hormone receptor binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001711963 RGD:3000	F		Seeded From UniProt	complete
involved_in	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104663 PANTHER:PTN001711963 RGD:3000 UniProtKB:P41159	P		Seeded From UniProt	complete
involved_in	GO:0038108	negative regulation of appetite by leptin-mediated signaling pathway	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001711963 RGD:3000	P		Seeded From UniProt	complete
involved_in	GO:0032868	response to insulin	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104663 PANTHER:PTN001711963 UniProtKB:G8BLB4 UniProtKB:P50595	P		Seeded From UniProt	complete
involved_in	GO:0032008	positive regulation of TOR signaling	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001711963 UniProtKB:P41159	P		Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104663 PANTHER:PTN001711963 RGD:3000 UniProtKB:P41159	P		Seeded From UniProt	complete
involved_in	GO:0007260	tyrosine phosphorylation of STAT protein	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104663 PANTHER:PTN001711963	P		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104663 PANTHER:PTN001711963	P		Seeded From UniProt	complete
involved_in	GO:0006112	energy reserve metabolic process	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001711963 RGD:3000	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104663 PANTHER:PTN001711963 RGD:3000 UniProtKB:G8BLB4 UniProtKB:O42164 UniProtKB:P50595	C		Seeded From UniProt	complete
enables	GO:0005179	hormone activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001711963 RGD:3000	F		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005179	P		Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000065	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000065	C		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000065	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Dridi, S et al. (2005) Mode of leptin action in chicken hypothalamus. Brain Res. 1047 214-23 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Paczoska-Eliasiewicz, HE et al. (2006) Exogenous leptin advances puberty in domestic hen. Domest. Anim. Endocrinol. 31 211-26 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Paczoska-Eliasiewicz, HE et al. (2003) Attenuation by leptin of the effects of fasting on ovarian function in hens (Gallus domesticus). Reproduction 126 739-51 PubMed GONUTS page
↑ ^4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:15907812-1] 1.0 ^1.1 ^1.2 ^1.3 Dridi, S et al. (2005) Mode of leptin action in chicken hypothalamus. Brain Res. 1047 214-23 PubMed GONUTS page

[PMID:16303278-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Paczoska-Eliasiewicz, HE et al. (2006) Exogenous leptin advances puberty in domestic hen. Domest. Anim. Endocrinol. 31 211-26 PubMed GONUTS page

[PMID:14748693-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Paczoska-Eliasiewicz, HE et al. (2003) Attenuation by leptin of the effects of fasting on ovarian function in hens (Gallus domesticus). Reproduction 126 739-51 PubMed GONUTS page

[PMID:21873635-4] 4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CHICK:LEP

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