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CHICK:IOD2

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) DIO2
Protein Name(s) Type II iodothyronine deiodinase

5DII DIOII Type 2 DI Type-II 5'-deiodinase

External Links
UniProt Q9IAX2
EMBL AF125575
UniGene Gga.1819
Gga.51485
ProteinModelPortal Q9IAX2
PRIDE Q9IAX2
HOVERGEN HBG000099
InParanoid Q9IAX2
PhylomeDB Q9IAX2
Proteomes UP000000539
GO GO:0016021
GO:0004800
GO:0042446
GO:0006590
InterPro IPR000643
IPR008261
IPR012336
PANTHER PTHR11781
Pfam PF00837
PIRSF PIRSF001330
SUPFAM SSF52833
PROSITE PS01205

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0006590

thyroid hormone generation

PMID:12270789[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004800

thyroxine 5'-deiodinase activity

PMID:10318780[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0042403

thyroid hormone metabolic process

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000207341
RGD:68418
UniProtKB:Q92813

P

Seeded From UniProt

complete

enables

GO:0004800

thyroxine 5'-deiodinase activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1306782
MGI:MGI:1338833
MGI:MGI:94896
PANTHER:PTN000207341
RGD:2504
RGD:68418
UniProtKB:Q92813
UniProtKB:Q9IAX2

F

Seeded From UniProt

complete

enables

GO:0004800

thyroxine 5'-deiodinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000643
InterPro:IPR008261

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000643
InterPro:IPR008261

P

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

involved_in

GO:0042446

hormone biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0893

P

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472
UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Van der Geyten, S et al. (2002) Differential expression of iodothyronine deiodinases in chicken tissues during the last week of embryonic development. Gen. Comp. Endocrinol. 128 65-73 PubMed GONUTS page
  2. Gereben, B et al. (1999) Cloning and expression of the chicken type 2 iodothyronine 5'-deiodinase. J. Biol. Chem. 274 13768-76 PubMed GONUTS page
  3. 3.0 3.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page