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CHICK:HMGCL

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) HMGCL
Protein Name(s) Hydroxymethylglutaryl-CoA lyase, mitochondrial

HL HMG-CoA lyase 3-hydroxy-3-methylglutarate-CoA lyase

External Links
UniProt P35915
EMBL L07034
PIR B45470
UniGene Gga.2537
ProteinModelPortal P35915
SMR P35915
IntAct P35915
STRING 9031.ENSGALP00000034301
PaxDb P35915
PRIDE P35915
eggNOG COG0119
HOGENOM HOG000219757
HOVERGEN HBG064656
InParanoid P35915
PhylomeDB P35915
UniPathway UPA00896
PRO PR:P35915
Proteomes UP000000539
GO GO:0005759
GO:0005777
GO:0004419
GO:0046872
GO:0046951
Gene3D 3.20.20.70
InterPro IPR013785
IPR030020
IPR000138
IPR000891
PANTHER PTHR10277:SF35
Pfam PF00682
PROSITE PS01062
PS50991

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0046951

ketone body biosynthetic process

PMID:22865860[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P35914

F

Seeded From UniProt

complete

enables

GO:0004419

hydroxymethylglutaryl-CoA lyase activity

PMID:22865860[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004419

hydroxymethylglutaryl-CoA lyase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P35914

F

Seeded From UniProt

complete

involved_in

GO:0046951

ketone body biosynthetic process

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000031222
RGD:620554
UniProtKB:P35914
UniProtKB:P35915
UniProtKB:Q8TB92

P

Seeded From UniProt

complete

involved_in

GO:0006629

lipid metabolic process

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000031222
UniProtKB:P35914

P

Seeded From UniProt

complete

involved_in

GO:0006552

leucine catabolic process

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000031222
UniProtKB:Q5B2F7
UniProtKB:Q9I2A0

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:96158
PANTHER:PTN000031254
RGD:620554
UniProtKB:P35914

C

Seeded From UniProt

complete

enables

GO:0004419

hydroxymethylglutaryl-CoA lyase activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000031222
RGD:620554
UniProtKB:O81027
UniProtKB:P35914
UniProtKB:P35915
UniProtKB:Q8TB92
UniProtKB:Q9I2A0

F

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000891
InterPro:IPR013785

F

Seeded From UniProt

complete

enables

GO:0004419

hydroxymethylglutaryl-CoA lyase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000138

F

Seeded From UniProt

complete

enables

GO:0004419

hydroxymethylglutaryl-CoA lyase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:4.1.3.4

F

Seeded From UniProt

complete

part_of

GO:0005777

peroxisome

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0576
UniProtKB-SubCell:SL-0204

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0016829

lyase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0456

F

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0170

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Montgomery, C et al. (2012) Identification and characterization of an extramitochondrial human 3-hydroxy-3-methylglutaryl-CoA lyase. J. Biol. Chem. 287 33227-36 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page