CHICK:HBEGF

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	HBEGF (synonyms: HEGFL)
Protein Name(s)	Proheparin-binding EGF-like growth factor Heparin-binding EGF-like growth factor HB-EGF HBEGF
External Links
UniProt	Q9W7C5
EMBL	AF131224
RefSeq	NP_990180.1
UniGene	Gga.389
ProteinModelPortal	Q9W7C5
SMR	Q9W7C5
STRING	9031.ENSGALP00000001399
PaxDb	Q9W7C5
PRIDE	Q9W7C5
Ensembl	ENSGALT00000001401
GeneID	395654
KEGG	gga:395654
CTD	1839
eggNOG	NOG45526
GeneTree	ENSGT00530000063708
HOGENOM	HOG000026782
HOVERGEN	HBG053952
InParanoid	Q9W7C5
KO	K08523
OMA	YSYDHTT
OrthoDB	EOG7VQJGP
PhylomeDB	Q9W7C5
TreeFam	TF332773
Reactome	REACT_189763 REACT_194392 REACT_194393 REACT_194394 REACT_194410 REACT_196285 REACT_196847 REACT_196849 REACT_197054 REACT_198076 REACT_244793
NextBio	20815726
PRO	PR:Q9W7C5
Proteomes	UP000000539
GO	GO:0009986 GO:0005615 GO:0005887 GO:0008201 GO:0021545 GO:0007173 GO:0051549 GO:0051897 GO:0048661 GO:0090303 GO:0008016 GO:0035313
InterPro	IPR000742 IPR013032 IPR015497
PANTHER	PTHR10740
Pfam	PF00008
SMART	SM00181
PROSITE	PS00022 PS01186 PS50026

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0021545	cranial nerve development	PMID:17229890^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107508 MGI:MGI:88068 MGI:MGI:96070 MGI:MGI:98724 MGI:MGI:99439 PANTHER:PTN000843338 RGD:2149 RGD:3849 RGD:620299 UniProtKB:O14944 UniProtKB:P15514 UniProtKB:Q6UW88	P	Seeded From UniProt	complete
enables	GO:0008201	heparin binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96070 PANTHER:PTN000077739 UniProtKB:Q99075	F	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1919170 MGI:MGI:96070 PANTHER:PTN000843338 RGD:2149 RGD:2526 RGD:620275 RGD:620299 UniProtKB:P01135 UniProtKB:Q6UW88 UniProtKB:Q99075	F	Seeded From UniProt	complete
involved_in	GO:0007173	epidermal growth factor receptor signaling pathway	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107508 MGI:MGI:96070 PANTHER:PTN000843338 RGD:2149 RGD:2526 RGD:620275 UniProtKB:P15514 UniProtKB:Q99075	P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96070 PANTHER:PTN000077739	C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107508 MGI:MGI:96070 PANTHER:PTN000843338 RGD:2149 RGD:3849 RGD:620299 UniProtKB:O14944 UniProtKB:P01135 UniProtKB:P15514 UniProtKB:Q99075	C	Seeded From UniProt	complete
enables	GO:0005154	epidermal growth factor receptor binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107508 MGI:MGI:1919170 MGI:MGI:96070 PANTHER:PTN000843338 RGD:2149 RGD:2526 RGD:3849 RGD:620275 UniProtKB:P01135 UniProtKB:Q6UW88	F	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008083	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P	Seeded From UniProt	complete
involved_in	GO:0051549	positive regulation of keratinocyte migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06186 ensembl:ENSMUSP00000025363	P	Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06186 ensembl:ENSMUSP00000025363	P	Seeded From UniProt	complete
involved_in	GO:0048661	positive regulation of smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06186 ensembl:ENSMUSP00000025363	P	Seeded From UniProt	complete
involved_in	GO:0035313	wound healing, spreading of epidermal cells	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06186 ensembl:ENSMUSP00000025363	P	Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06186 ensembl:ENSMUSP00000025363	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06186 ensembl:ENSMUSP00000025363	P	Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06186 ensembl:ENSMUSP00000025363	F	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06186 ensembl:ENSMUSP00000025363	F	Seeded From UniProt	complete
involved_in	GO:0008016	regulation of heart contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06186 ensembl:ENSMUSP00000025363	P	Seeded From UniProt	complete
involved_in	GO:0007173	epidermal growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06186 ensembl:ENSMUSP00000025363	P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06186 ensembl:ENSMUSP00000025363	C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06186 ensembl:ENSMUSP00000025363	C	Seeded From UniProt	complete
enables	GO:0005154	epidermal growth factor receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06186 ensembl:ENSMUSP00000025363	F	Seeded From UniProt	complete
involved_in	GO:0090303	positive regulation of wound healing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99075 ensembl:ENSP00000230990	P	Seeded From UniProt	complete
involved_in	GO:0060326	cell chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99075 ensembl:ENSP00000230990	P	Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99075 ensembl:ENSP00000230990	P	Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99075 ensembl:ENSP00000230990	P	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99075 ensembl:ENSP00000230990	C	Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99075 ensembl:ENSP00000230990	F	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99075 ensembl:ENSP00000230990	F	Seeded From UniProt	complete
involved_in	GO:0007173	epidermal growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99075 ensembl:ENSP00000230990	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99075 ensembl:ENSP00000230990	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0339	F	Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0358	F	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0112	C	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Hoshino, H et al. (2007) Cornichon-like protein facilitates secretion of HB-EGF and regulates proper development of cranial nerves. Mol. Biol. Cell 18 1143-52 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17229890-1] Hoshino, H et al. (2007) Cornichon-like protein facilitates secretion of HB-EGF and regulates proper development of cranial nerves. Mol. Biol. Cell 18 1143-52 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[1]

[2]

CHICK:HBEGF

Contents

Annotations

Notes

References

a

c

d

e

g

h

i

m

n

p

r

s

t

v

w

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools