CHICK:GREM1

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	GREM1
Protein Name(s)	Gremlin-1
External Links
UniProt	O73755
EMBL	AF045799
RefSeq	NP_990309.1
UniGene	Gga.2961
ProteinModelPortal	O73755
STRING	9031.ENSGALP00000037126
Ensembl	ENSGALT00000015827
GeneID	395826
KEGG	gga:395826
CTD	26585
eggNOG	NOG41424
GeneTree	ENSGT00510000046909
HOGENOM	HOG000237358
HOVERGEN	HBG051837
InParanoid	O73755
OMA	RVKECRC
OrthoDB	EOG7Q2N7B
PhylomeDB	O73755
TreeFam	TF106445
NextBio	20815894
PRO	PR:O73755
Proteomes	UP000000539
GO	GO:0009986 GO:0005615 GO:0030297 GO:0001658 GO:0002042 GO:0007267 GO:0030199 GO:0048263 GO:0030326 GO:0060173 GO:0003337 GO:0043066 GO:0030514 GO:1900158 GO:0046851 GO:1900155 GO:0090191 GO:0090090 GO:0032331 GO:0033689 GO:0090291 GO:0060394 GO:0045892 GO:0045766 GO:0090190 GO:2000727 GO:0008284 GO:0042346 GO:0051092 GO:1900086 GO:0002092 GO:0051973 GO:0003257 GO:0009954 GO:0010717 GO:0051893 GO:0060676
InterPro	IPR006207 IPR004133 IPR017159
Pfam	PF03045
PIRSF	PIRSF037254
SMART	SM00041

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0060173	limb development	PMID:9660951^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60565	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:9660951^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60565	P	occurs_in:(UBERON:0006012)	Seeded From UniProt	complete
involved_in	GO:0032331	negative regulation of chondrocyte differentiation	PMID:9660951^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60565	P		Seeded From UniProt	complete
involved_in	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0030297	P		Seeded From UniProt	complete
involved_in	GO:1900158	negative regulation of bone mineralization involved in bone maturation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60565 ensembl:ENSP00000478319	P		Seeded From UniProt	complete
involved_in	GO:1900155	negative regulation of bone trabecula formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60565 ensembl:ENSP00000478319	P		Seeded From UniProt	complete
involved_in	GO:0090291	negative regulation of osteoclast proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60565 ensembl:ENSP00000478319	P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60565 ensembl:ENSP00000478319	P		Seeded From UniProt	complete
involved_in	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60565 ensembl:ENSP00000478319	P		Seeded From UniProt	complete
involved_in	GO:0060173	limb development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60565 ensembl:ENSP00000478319	P		Seeded From UniProt	complete
involved_in	GO:0051973	positive regulation of telomerase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60565 ensembl:ENSP00000478319	P		Seeded From UniProt	complete
involved_in	GO:0048263	determination of dorsal identity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60565 ensembl:ENSP00000478319	P		Seeded From UniProt	complete
involved_in	GO:0046851	negative regulation of bone remodeling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60565 ensembl:ENSP00000478319	P		Seeded From UniProt	complete
involved_in	GO:0045668	negative regulation of osteoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60565 ensembl:ENSP00000478319	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60565 ensembl:ENSP00000478319	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60565 ensembl:ENSP00000478319	F		Seeded From UniProt	complete
enables	GO:0036122	BMP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60565 ensembl:ENSP00000478319	F		Seeded From UniProt	complete
involved_in	GO:0033689	negative regulation of osteoblast proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60565 ensembl:ENSP00000478319	P		Seeded From UniProt	complete
involved_in	GO:0032331	negative regulation of chondrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60565 ensembl:ENSP00000478319	P		Seeded From UniProt	complete
involved_in	GO:0030514	negative regulation of BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60565 ensembl:ENSP00000478319	P		Seeded From UniProt	complete
involved_in	GO:0030502	negative regulation of bone mineralization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60565 ensembl:ENSP00000478319	P		Seeded From UniProt	complete
involved_in	GO:0030199	collagen fibril organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60565 ensembl:ENSP00000478319	P		Seeded From UniProt	complete
involved_in	GO:0010717	regulation of epithelial to mesenchymal transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60565 ensembl:ENSP00000478319	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60565 ensembl:ENSP00000478319	P		Seeded From UniProt	complete
involved_in	GO:0000902	cell morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60565 ensembl:ENSP00000478319	P		Seeded From UniProt	complete
involved_in	GO:2000727	positive regulation of cardiac muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70326 ensembl:ENSMUSP00000097170	P		Seeded From UniProt	complete
involved_in	GO:2000273	positive regulation of signaling receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70326 ensembl:ENSMUSP00000097170	P		Seeded From UniProt	complete
involved_in	GO:1901224	positive regulation of NIK/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70326 ensembl:ENSMUSP00000097170	P		Seeded From UniProt	complete
involved_in	GO:1900086	positive regulation of peptidyl-tyrosine autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70326 ensembl:ENSMUSP00000097170	P		Seeded From UniProt	complete
involved_in	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70326 ensembl:ENSMUSP00000097170	P		Seeded From UniProt	complete
involved_in	GO:0061098	positive regulation of protein tyrosine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70326 ensembl:ENSMUSP00000097170	P		Seeded From UniProt	complete
involved_in	GO:0060676	ureteric bud formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70326 ensembl:ENSMUSP00000097170	P		Seeded From UniProt	complete
involved_in	GO:0051893	regulation of focal adhesion assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70326 ensembl:ENSMUSP00000097170	P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70326 ensembl:ENSMUSP00000097170	P		Seeded From UniProt	complete
enables	GO:0048018	receptor ligand activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70326 ensembl:ENSMUSP00000097170	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70326 ensembl:ENSMUSP00000097170	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70326 ensembl:ENSMUSP00000097170	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70326 ensembl:ENSMUSP00000097170	P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70326 ensembl:ENSMUSP00000097170	P		Seeded From UniProt	complete
involved_in	GO:0043542	endothelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70326 ensembl:ENSMUSP00000097170	P		Seeded From UniProt	complete
enables	GO:0043184	vascular endothelial growth factor receptor 2 binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70326 ensembl:ENSMUSP00000097170	F		Seeded From UniProt	complete
involved_in	GO:0030514	negative regulation of BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70326 ensembl:ENSMUSP00000097170	P		Seeded From UniProt	complete
involved_in	GO:0030326	embryonic limb morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70326 ensembl:ENSMUSP00000097170	P		Seeded From UniProt	complete
enables	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70326 ensembl:ENSMUSP00000097170	F		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70326 ensembl:ENSMUSP00000097170	C		Seeded From UniProt	complete
involved_in	GO:0009954	proximal/distal pattern formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70326 ensembl:ENSMUSP00000097170	P		Seeded From UniProt	complete
involved_in	GO:0009887	animal organ morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70326 ensembl:ENSMUSP00000097170	P		Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70326 ensembl:ENSMUSP00000097170	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70326 ensembl:ENSMUSP00000097170	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70326 ensembl:ENSMUSP00000097170	C		Seeded From UniProt	complete
involved_in	GO:0003337	mesenchymal to epithelial transition involved in metanephros morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70326 ensembl:ENSMUSP00000097170	P		Seeded From UniProt	complete
involved_in	GO:0003257	positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70326 ensembl:ENSMUSP00000097170	P		Seeded From UniProt	complete
involved_in	GO:0002092	positive regulation of receptor internalization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70326 ensembl:ENSMUSP00000097170	P		Seeded From UniProt	complete
involved_in	GO:0002042	cell migration involved in sprouting angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70326 ensembl:ENSMUSP00000097170	P		Seeded From UniProt	complete
involved_in	GO:0001658	branching involved in ureteric bud morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70326 ensembl:ENSMUSP00000097170	P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O70326 ensembl:ENSMUSP00000097170	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Hsu, DR et al. (1998) The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities. Mol. Cell 1 673-83 PubMed GONUTS page

[PMID:9660951-1] 1.0 ^1.1 ^1.2 Hsu, DR et al. (1998) The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities. Mol. Cell 1 673-83 PubMed GONUTS page

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CHICK:GREM1

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