CHICK:G0W2S9

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	LRP2 (ECO:0000313 with EMBL:CCD17864.1)
Protein Name(s)	Low-density lipoprotein receptor-related protein-2 (ECO:0000313 with EMBL:CCD17864.1)
External Links
UniProt	G0W2S9
EMBL	HE578280
UniGene	Gga.54772 Gga.56301
Gene3D	4.10.400.10
InterPro	IPR023415 IPR002172
Pfam	PF00057
PRINTS	PR00261
SMART	SM00192
SUPFAM	SSF57424
PROSITE	PS01209 PS50068

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0030284	estrogen receptor activity	PMID:22868208^[1]	ECO:0000314			F	Figure 4B shows LRP2 expression in the kidneys of both hens and roosters. There is greater expression of LRP2 in hen kidneys, suggesting LRP2 is over-expressed in response to estrogen.	complete CACAO 9767
	GO:0030284	estrogen receptor activity	PMID:22868208^[1]	ECO:0000315			F	Figure 5:B and C. Western blot shows that LRP2 expression is increased in roosters treated with estrogen. Roosters treated with estrogen and then sacrificed within a 24 hour period (2, 5, 6) had the greatest amount of over-expression. Roosters who were treated with estrogen, and then sacrificed later than 24 hours (sacrifice at 48 hours -3- or 72 hours -4-). Roosters treated with estrogen multiple times (5 and 6) had the most over-expression of LRP2.	complete CACAO 9768
enables	GO:0030284	estrogen receptor activity	PMID:22868208^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0043401	steroid hormone mediated signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0030284	P	Seeded From UniProt	complete
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↑ ^1.0 ^1.1 ^1.2 Plieschnig, JA et al. (2012) Renal LRP2 expression in man and chicken is estrogen-responsive. Gene 508 49-59 PubMed GONUTS page