CHICK:FAS

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	FASN (synonyms: FAS)
Protein Name(s)	Fatty acid synthase [Acyl-carrier-protein] S-acetyltransferase [Acyl-carrier-protein] S-malonyltransferase 3-oxoacyl-[acyl-carrier-protein] synthase 3-oxoacyl-[acyl-carrier-protein] reductase 3-hydroxyacyl-[acyl-carrier-protein] dehydratase Enoyl-[acyl-carrier-protein] reductase Oleoyl-[acyl-carrier-protein] hydrolase
External Links
UniProt	P12276
EMBL	J03860 J04485 J02839
PIR	S57248
UniGene	Gga.8951
ProteinModelPortal	P12276
SMR	P12276
STRING	9031.ENSGALP00000038133
BindingDB	P12276
ChEMBL	CHEMBL1795136
ESTHER	chick-fas
PaxDb	P12276
PRIDE	P12276
eggNOG	COG3319
HOGENOM	HOG000019642
HOVERGEN	HBG005640
InParanoid	P12276
PhylomeDB	P12276
SABIO-RK	P12276
NextBio	20816121
PRO	PR:P12276
Proteomes	UP000000539
GO	GO:0047451 GO:0004317 GO:0004316 GO:0004315 GO:0004313 GO:0004314 GO:0047117 GO:0004319 GO:0016295 GO:0004320 GO:0016296 GO:0008270 GO:0006633
Gene3D	1.10.1200.10 1.10.1470.20 3.40.366.10 3.40.47.10 3.40.50.150 3.40.50.1820 3.40.50.720
InterPro	IPR029058 IPR001227 IPR009081 IPR014043 IPR016035 IPR013149 IPR002198 IPR023102 IPR011032 IPR018201 IPR014031 IPR014030 IPR016036 IPR016040 IPR020807 IPR020843 IPR013968 IPR006162 IPR029063 IPR001031 IPR016039
Pfam	PF00698 PF00106 PF00107 PF00109 PF02801 PF00550 PF14765 PF00975
SMART	SM00829 SM00822
SUPFAM	SSF47336 SSF50129 SSF52151 SSF53335 SSF53474 SSF53901 SSF55048
PROSITE	PS50075 PS00606 PS00012

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0003697	single-stranded DNA binding	PMID:2842766^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005623	cell	PMID:16455759^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001898) part_of:(UBERON:0002746) part_of:(UBERON:0001932)\|part_of:(UBERON:0002107)\|part_of:(UBERON:0001630)\|part_of:(UBERON:0000955)	Seeded From UniProt	complete
involved_in	GO:0032100	positive regulation of appetite	PMID:16455759^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006089	lactate metabolic process	PMID:16455759^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016039	F		Seeded From UniProt	complete
enables	GO:0004312	fatty acid synthase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR023102	F		Seeded From UniProt	complete
involved_in	GO:0009058	biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001031	P		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020843	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001227	F		Seeded From UniProt	complete
enables	GO:0016788	hydrolase activity, acting on ester bonds	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001031	F		Seeded From UniProt	complete
enables	GO:0031177	phosphopantetheine binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020806	F		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013149	P		Seeded From UniProt	complete
enables	GO:0008659	(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:4.2.1.59	F		Seeded From UniProt	complete
enables	GO:0004320	oleoyl-[acyl-carrier-protein] hydrolase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.2.14	F		Seeded From UniProt	complete
enables	GO:0004315	3-oxoacyl-[acyl-carrier-protein] synthase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.3.1.41	F		Seeded From UniProt	complete
enables	GO:0016418	S-acetyltransferase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.3.1.38	F		Seeded From UniProt	complete
enables	GO:0004312	fatty acid synthase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.3.1.85	F		Seeded From UniProt	complete
enables	GO:0102131	3-oxo-glutaryl-[acp] methyl ester reductase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.1.1.100	F		Seeded From UniProt	complete
enables	GO:0047451	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:4.2.1.59	F		Seeded From UniProt	complete
enables	GO:0016297	acyl-[acyl-carrier-protein] hydrolase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.2.14	F		Seeded From UniProt	complete
enables	GO:0016296	palmitoyl-[acyl-carrier-protein] hydrolase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.2.14	F		Seeded From UniProt	complete
enables	GO:0004314	[acyl-carrier-protein] S-malonyltransferase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.3.1.39	F		Seeded From UniProt	complete
enables	GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.1.1.100	F		Seeded From UniProt	complete
enables	GO:0004313	[acyl-carrier-protein] S-acetyltransferase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.3.1.38	F		Seeded From UniProt	complete
enables	GO:0102132	3-oxo-pimeloyl-[acp] methyl ester reductase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.1.1.100	F		Seeded From UniProt	complete
enables	GO:0047117	enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.3.1.39	F		Seeded From UniProt	complete
enables	GO:0016419	S-malonyltransferase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.3.1.39	F		Seeded From UniProt	complete
enables	GO:0016295	myristoyl-[acyl-carrier-protein] hydrolase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.2.14	F		Seeded From UniProt	complete
enables	GO:0019171	3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:4.2.1.59	F		Seeded From UniProt	complete
part_of	GO:0005623	cell	PMID:16455759^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001898) part_of:(UBERON:0002746) part_of:(UBERON:0001932)\|part_of:(UBERON:0002107)\|part_of:(UBERON:0001630)\|part_of:(UBERON:0000955)	Seeded From UniProt	complete
involved_in	GO:0032100	positive regulation of appetite	PMID:16455759^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006089	lactate metabolic process	PMID:16455759^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004312	fatty acid synthase activity	PMID:2842766^[1]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0016829	lyase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0456	F		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
involved_in	GO:0006631	fatty acid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0276	P		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	P		Seeded From UniProt	complete
involved_in	GO:0006633	fatty acid biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0275	P		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Yuan, ZY et al. (1988) Molecular cloning and sequencing of DNA complementary to chicken liver fatty acid synthase mRNA. Proc. Natl. Acad. Sci. U.S.A. 85 6328-31 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Dridi, S et al. (2006) FAS inhibitor cerulenin reduces food intake and melanocortin receptor gene expression without modulating the other (an)orexigenic neuropeptides in chickens. Am. J. Physiol. Regul. Integr. Comp. Physiol. 291 R138-47 PubMed GONUTS page

[PMID:2842766-1] 1.0 ^1.1 Yuan, ZY et al. (1988) Molecular cloning and sequencing of DNA complementary to chicken liver fatty acid synthase mRNA. Proc. Natl. Acad. Sci. U.S.A. 85 6328-31 PubMed GONUTS page

[PMID:16455759-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Dridi, S et al. (2006) FAS inhibitor cerulenin reduces food intake and melanocortin receptor gene expression without modulating the other (an)orexigenic neuropeptides in chickens. Am. J. Physiol. Regul. Integr. Comp. Physiol. 291 R138-47 PubMed GONUTS page

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CHICK:FAS

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