CHICK:CYB

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	MT-CYB (synonyms: COB, CYTB, MTCYB)
Protein Name(s)	Cytochrome b Complex III subunit 3 Complex III subunit III Cytochrome b-c1 complex subunit 3 Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
External Links
UniProt	P18946
EMBL	X52392 L08376
PIR	S10198
RefSeq	NP_006926.1
PDB	1BCC 1LLY 2BCC 3BCC 3CWB 3H1H 3H1I 3H1J 3H1K 3H1L 3L70 3L71 3L72 3L73 3L74 3L75 3TGU
PDBsum	1BCC 1LLY 2BCC 3BCC 3CWB 3H1H 3H1I 3H1J 3H1K 3H1L 3L70 3L71 3L72 3L73 3L74 3L75 3TGU
ProteinModelPortal	P18946
SMR	P18946
STRING	9031.ENSGALP00000034623
PaxDb	P18946
Ensembl	ENSGALT00000029080
GeneID	807641
KEGG	gga:807641
CTD	4519
eggNOG	COG1290
GeneTree	ENSGT00390000017948
HOGENOM	HOG000255206
HOVERGEN	HBG017694
InParanoid	P18946
KO	K00412
OMA	FFFVAVY
OrthoDB	EOG7BGHKX
PhylomeDB	P18946
TreeFam	TF353088
Reactome	REACT_314725
EvolutionaryTrace	P18946
NextBio	20934100
PRO	PR:P18946
Proteomes	UP000000539
ExpressionAtlas	P18946
GO	GO:0005743 GO:0045275 GO:0009055 GO:0046872 GO:0008121 GO:0006122
Gene3D	1.20.810.10
InterPro	IPR005798 IPR005797 IPR027387 IPR030689 IPR016174
Pfam	PF00032 PF13631
PIRSF	PIRSF038885
SUPFAM	SSF81342 SSF81648
PROSITE	PS51003 PS51002

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0005737	cytoplasm	PMID:18796602^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:18796602^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0022904	respiratory electron transport chain	PMID:20075289^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	PMID:20075289^[2]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0020037	heme binding	PMID:22690928^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005750	mitochondrial respiratory chain complex III	PMID:22690928^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0031305	integral component of mitochondrial inner membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00158 ensembl:ENSMUSP00000081003	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00158 ensembl:ENSMUSP00000081003	C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00158 ensembl:ENSMUSP00000081003	C	Seeded From UniProt	complete
involved_in	GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030689	P	Seeded From UniProt	complete
enables	GO:0008121	ubiquinol-cytochrome-c reductase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030689	F	Seeded From UniProt	complete
enables	GO:0009055	electron transfer activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005797 InterPro:IPR005798 InterPro:IPR030689 InterPro:IPR036150	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005797 InterPro:IPR005798 InterPro:IPR016174 InterPro:IPR036150	C	Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005797 InterPro:IPR005798 InterPro:IPR036150	F	Seeded From UniProt	complete
involved_in	GO:0022904	respiratory electron transport chain	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016174	P	Seeded From UniProt	complete
part_of	GO:0045275	respiratory chain complex III	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030689	C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:20075289^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0999 UniProtKB-SubCell:SL-0168	C	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0249	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0070469	respirasome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0679	C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Komarov, AP et al. (2008) Functional genetic screening reveals the role of mitochondrial cytochrome b as a mediator of FAS-induced apoptosis. Proc. Natl. Acad. Sci. U.S.A. 105 14453-8 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Tinsley, N et al. (2010) Investigation of mitochondrial protein expression and oxidation in heart muscle in low and high feed efficient male broilers in a single genetic line. Poult. Sci. 89 349-52 PubMed GONUTS page
↑ ^3.0 ^3.1 Hao, GF et al. (2012) Computational discovery of picomolar Q(o) site inhibitors of cytochrome bc1 complex. J. Am. Chem. Soc. 134 11168-76 PubMed GONUTS page

[PMID:18796602-1] 1.0 ^1.1 Komarov, AP et al. (2008) Functional genetic screening reveals the role of mitochondrial cytochrome b as a mediator of FAS-induced apoptosis. Proc. Natl. Acad. Sci. U.S.A. 105 14453-8 PubMed GONUTS page

[PMID:20075289-2] 2.0 ^2.1 ^2.2 Tinsley, N et al. (2010) Investigation of mitochondrial protein expression and oxidation in heart muscle in low and high feed efficient male broilers in a single genetic line. Poult. Sci. 89 349-52 PubMed GONUTS page

[PMID:22690928-3] 3.0 ^3.1 Hao, GF et al. (2012) Computational discovery of picomolar Q(o) site inhibitors of cytochrome bc1 complex. J. Am. Chem. Soc. 134 11168-76 PubMed GONUTS page

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CHICK:CYB

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