CHICK:CP1A4

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	CYP1A4
Protein Name(s)	Cytochrome P450 1A4 CYPIA4 Cytochrome P450 TCDDAHH
External Links
UniProt	P79760
EMBL	X99453
RefSeq	NP_990478.1
UniGene	Gga.617
ProteinModelPortal	P79760
SMR	P79760
STRING	9031.ENSGALP00000039219
PaxDb	P79760
GeneID	396052
KEGG	gga:396052
CTD	396052
eggNOG	COG2124
HOGENOM	HOG000036991
HOVERGEN	HBG106944
InParanoid	P79760
PhylomeDB	P79760
NextBio	20816112
PRO	PR:P79760
Proteomes	UP000000539
GO	GO:0005789 GO:0070330 GO:0020037 GO:0005506
Gene3D	1.10.630.10
InterPro	IPR001128 IPR017972 IPR002401 IPR008066
Pfam	PF00067
PRINTS	PR00463 PR01683 PR00385
SUPFAM	SSF48264
PROSITE	PS00086

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0019825	oxygen binding	PMID:23474502^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0071615	oxidative deethylation	PMID:23474502^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070989	oxidative demethylation	PMID:23474502^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005623	cell	PMID:20580800^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0002107)	Seeded From UniProt	complete
involved_in	GO:0017144	drug metabolic process	PMID:20580800^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046677	response to antibiotic	PMID:20580800^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019825	oxygen binding	PMID:9224771^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(UBERON:0002113) occurs_in:(UBERON:0002107) has_direct_input:(CHEBI:27258) has_output:(CHEBI:27259) part_of:(GO:1904681)	Seeded From UniProt	complete
involved_in	GO:0071615	oxidative deethylation	PMID:9224771^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0002113) occurs_in:(UBERON:0002107)	Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001210461 RGD:2458 RGD:2459 UniProtKB:P05177	C		Seeded From UniProt	complete
enables	GO:0004497	monooxygenase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88588 PANTHER:PTN001210461 RGD:2458 RGD:2459 UniProtKB:P05177	F		Seeded From UniProt	complete
enables	GO:0005506	iron ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001128 InterPro:IPR002401 InterPro:IPR008066 InterPro:IPR036396	F		Seeded From UniProt	complete
enables	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001128 InterPro:IPR002401 InterPro:IPR017972 InterPro:IPR036396	F		Seeded From UniProt	complete
enables	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008066	F		Seeded From UniProt	complete
enables	GO:0020037	heme binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001128 InterPro:IPR002401 InterPro:IPR008066 InterPro:IPR036396	F		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001128 InterPro:IPR002401 InterPro:IPR008066 InterPro:IPR017972 InterPro:IPR036396	P		Seeded From UniProt	complete
enables	GO:0070330	aromatase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.14.14.1	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0492	C		Seeded From UniProt	complete
enables	GO:0004497	monooxygenase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0503	F		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
part_of	GO:0031090	organelle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0165	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Yang, J et al. (2013) Characterization of chicken cytochrome P450 1A4 and 1A5: inter-paralog comparisons of substrate preference and inhibitor selectivity. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 157 337-43 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Zhang, LL et al. (2011) Effects of fluoroquinolones on CYP4501A and 3A in male broilers. Res. Vet. Sci. 90 99-105 PubMed GONUTS page
↑ ^3.0 ^3.1 Sinclair, PR et al. (1997) Identification of CYP1A5 as the CYP1A enzyme mainly responsible for uroporphyrinogen oxidation induced by AH receptor ligands in chicken liver and kidney. Drug Metab. Dispos. 25 779-83 PubMed GONUTS page
↑ ^4.0 ^4.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23474502-1] 1.0 ^1.1 ^1.2 Yang, J et al. (2013) Characterization of chicken cytochrome P450 1A4 and 1A5: inter-paralog comparisons of substrate preference and inhibitor selectivity. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 157 337-43 PubMed GONUTS page

[PMID:20580800-2] 2.0 ^2.1 ^2.2 Zhang, LL et al. (2011) Effects of fluoroquinolones on CYP4501A and 3A in male broilers. Res. Vet. Sci. 90 99-105 PubMed GONUTS page

[PMID:9224771-3] 3.0 ^3.1 Sinclair, PR et al. (1997) Identification of CYP1A5 as the CYP1A enzyme mainly responsible for uroporphyrinogen oxidation induced by AH receptor ligands in chicken liver and kidney. Drug Metab. Dispos. 25 779-83 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CHICK:CP1A4

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