CHICK:CD40L

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	CD40LG (synonyms: CD40L, TNFSF5)
Protein Name(s)	CD40 ligand CD40-L Tumor necrosis factor ligand superfamily member 5 CD40 ligand, membrane form CD40 ligand, soluble form
External Links
UniProt	Q9I8D8
EMBL	AJ243435
RefSeq	NP_990064.1
UniGene	Gga.3027
ProteinModelPortal	Q9I8D8
STRING	9031.ENSGALP00000010340
PRIDE	Q9I8D8
Ensembl	ENSGALT00000010354
GeneID	395485
KEGG	gga:395485
CTD	959
eggNOG	NOG39330
GeneTree	ENSGT00510000048489
HOGENOM	HOG000111291
HOVERGEN	HBG079629
InParanoid	Q9I8D8
KO	K03161
OMA	SMKIFMY
PhylomeDB	Q9I8D8
Reactome	REACT_332781
NextBio	20815565
PRO	PR:Q9I8D8
Proteomes	UP000000539
ExpressionAtlas	Q9I8D8
GO	GO:0009897 GO:0005615 GO:0016021 GO:0005174 GO:0030183 GO:0042100 GO:0048305 GO:0006954 GO:0045190 GO:0043066 GO:0030168 GO:2000353 GO:0032735 GO:0051023
Gene3D	2.60.120.40
InterPro	IPR003263 IPR021184 IPR006052 IPR008983
Pfam	PF00229
PIRSF	PIRSF016527
PRINTS	PR01702
SMART	SM00207
SUPFAM	SSF49842
PROSITE	PS00251 PS50049

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0042100	B cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29965	P		Seeded From UniProt	complete
involved_in	GO:0030168	platelet activation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29965	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29965	P		Seeded From UniProt	complete
enables	GO:0005174	CD40 receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29965	F		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0051023	regulation of immunoglobulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27548 ensembl:ENSMUSP00000033466	P		Seeded From UniProt	complete
involved_in	GO:0048305	immunoglobulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27548 ensembl:ENSMUSP00000033466	P		Seeded From UniProt	complete
involved_in	GO:0045190	isotype switching	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27548 ensembl:ENSMUSP00000033466	P		Seeded From UniProt	complete
involved_in	GO:0030183	B cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27548 ensembl:ENSMUSP00000033466	P		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27548 ensembl:ENSMUSP00000033466	C		Seeded From UniProt	complete
involved_in	GO:2000353	positive regulation of endothelial cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29965 ensembl:ENSP00000359663	P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29965 ensembl:ENSP00000359663	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29965 ensembl:ENSP00000359663	P		Seeded From UniProt	complete
involved_in	GO:0042102	positive regulation of T cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29965 ensembl:ENSP00000359663	P		Seeded From UniProt	complete
involved_in	GO:0042100	B cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29965 ensembl:ENSP00000359663	P		Seeded From UniProt	complete
involved_in	GO:0032753	positive regulation of interleukin-4 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29965 ensembl:ENSP00000359663	P		Seeded From UniProt	complete
involved_in	GO:0032735	positive regulation of interleukin-12 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29965 ensembl:ENSP00000359663	P		Seeded From UniProt	complete
involved_in	GO:0032733	positive regulation of interleukin-10 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29965 ensembl:ENSP00000359663	P		Seeded From UniProt	complete
involved_in	GO:0030168	platelet activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29965 ensembl:ENSP00000359663	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29965 ensembl:ENSP00000359663	C		Seeded From UniProt	complete
involved_in	GO:0007257	activation of JUN kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29965 ensembl:ENSP00000359663	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29965 ensembl:ENSP00000359663	P		Seeded From UniProt	complete
enables	GO:0005174	CD40 receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29965 ensembl:ENSP00000359663	F		Seeded From UniProt	complete
enables	GO:0005164	tumor necrosis factor receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003263 InterPro:IPR006052	F		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003263 InterPro:IPR006052	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003263 InterPro:IPR006052	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0310	C		Seeded From UniProt	complete
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References

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