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CHICK:CAN2

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) CAPN2
Protein Name(s) Calpain-2 catalytic subunit

Calcium-activated neutral proteinase 2 CANP 2 Calpain M-type Calpain-2 large subunit Millimolar-calpain M-calpain

External Links
UniProt Q92178
EMBL D38026
PIR S57194
RefSeq NP_990411.1
UniGene Gga.3677
ProteinModelPortal Q92178
SMR Q92178
STRING 9031.ENSGALP00000015225
MEROPS C02.002
PaxDb Q92178
GeneID 395963
KEGG gga:395963
CTD 824
eggNOG NOG327523
HOGENOM HOG000232035
HOVERGEN HBG012645
InParanoid Q92178
KO K03853
PhylomeDB Q92178
BRENDA 3.4.22.53
NextBio 20816028
PRO PR:Q92178
Proteomes UP000000539
GO GO:0005737
GO:0030425
GO:0005886
GO:0005509
GO:0004198
GO:0071230
GO:0006508
GO:0051493
Gene3D 1.10.238.10
InterPro IPR022684
IPR022682
IPR022683
IPR029539
IPR011992
IPR018247
IPR002048
IPR000169
IPR001300
PANTHER PTHR10183:SF268
Pfam PF01067
PF00648
PRINTS PR00704
SMART SM00720
SM00230
SM00054
SUPFAM SSF49758
PROSITE PS50203
PS00018
PS50222
PS00139

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0071230

cellular response to amino acid stimulus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07009

P

Seeded From UniProt

complete

involved_in

GO:0071230

cellular response to amino acid stimulus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O08529

P

Seeded From UniProt

complete

part_of

GO:0030425

dendrite

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07009

C

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07009

P

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O08529

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07009

C

Seeded From UniProt

complete

enables

GO:0004198

calcium-dependent cysteine-type endopeptidase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O08529

F

Seeded From UniProt

complete

enables

GO:0004198

calcium-dependent cysteine-type endopeptidase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07009

F

Seeded From UniProt

complete

enables

GO:1990782

protein tyrosine kinase binding

PMID:15340073[1]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q00944

F

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0012051
FB:FBgn0025866
MGI:MGI:107437
MGI:MGI:88263
MGI:MGI:88264
PANTHER:PTN000021568
RGD:2267
RGD:2268
RGD:2269
RGD:69354
UniProtKB:P07384
UniProtKB:P20807
UniProtKB:P35750
UniProtKB:Q9HC96
WB:WBGene00006606

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0025866
FB:FBgn0260450
MGI:MGI:107437
MGI:MGI:88264
PANTHER:PTN000021568
RGD:2268
RGD:2269
RGD:69354
UniProtKB:P20807
UniProtKB:P35750
UniProtKB:Q8RVL2

C

Seeded From UniProt

complete

enables

GO:0004198

calcium-dependent cysteine-type endopeptidase activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0012051
FB:FBgn0025866
MGI:MGI:107437
MGI:MGI:2181366
MGI:MGI:88263
PANTHER:PTN000021568
RGD:2267
RGD:2269
RGD:69354
UniProtKB:P07384
UniProtKB:P17655
UniProtKB:P35750
UniProtKB:Q9HC96

F

Seeded From UniProt

complete

enables

GO:0004198

calcium-dependent cysteine-type endopeptidase activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0012051
FB:FBgn0025866
MGI:MGI:107437
MGI:MGI:2181366
MGI:MGI:88263
MGI:MGI:88264
PANTHER:PTN000021568
RGD:2267
RGD:2268
RGD:2269
RGD:69354
UniProtKB:P07384
UniProtKB:P17655
UniProtKB:P35750
UniProtKB:Q9HC96

F

Seeded From UniProt

complete

enables

GO:0004198

calcium-dependent cysteine-type endopeptidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001300
InterPro:IPR022684
InterPro:IPR029539

F

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002048
InterPro:IPR029539

F

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001300
InterPro:IPR022684
InterPro:IPR029539

P

Seeded From UniProt

complete

involved_in

GO:0051493

regulation of cytoskeleton organization

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029539

P

Seeded From UniProt

complete

enables

GO:0008234

cysteine-type peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0788

F

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Westhoff, MA et al. (2004) SRC-mediated phosphorylation of focal adhesion kinase couples actin and adhesion dynamics to survival signaling. Mol. Cell. Biol. 24 8113-33 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page