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CHICK:B4ER10

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) IFNL (synonyms: IFN-lambda, IL28B)
Protein Name(s) Interferon lambda

Interferon-lambda Uncharacterized protein

External Links
UniProt B4ER10
EMBL KF680103
AM773754
RefSeq XP_004950144.1
UniGene Gga.47678
Ensembl ENSGALT00000042738
ENSGALT00000043036
GeneID 101751261
KEGG gga:101751261
GeneTree ENSGT00390000014310
HOVERGEN HBG052108
KO K05447
InterPro IPR029177
Pfam PF15177

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:2000379

positive regulation of reactive oxygen species metabolic process

PMID:18593329[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

PMID:18593329[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045918

negative regulation of cytolysis

PMID:18593329[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

NOT|involved_in

GO:0034141

positive regulation of toll-like receptor 3 signaling pathway

PMID:18593329[1]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

PMID:24371053[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045071

negative regulation of viral genome replication

PMID:24371053[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:3647279
PANTHER:PTN001277107
UniProtKB:B4ER10
UniProtKB:K9M1U5
UniProtKB:Q8IU54

P

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2450574
PANTHER:PTN001277107

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2450574
PANTHER:PTN001277107
UniProtKB:K9M1U5

C

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001277107
UniProtKB:Q8IU54

F

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

enables

GO:0005125

cytokine activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029177

F

Seeded From UniProt

complete

involved_in

GO:0007259

receptor signaling pathway via JAK-STAT

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029177

P

Seeded From UniProt

complete

involved_in

GO:0050778

positive regulation of immune response

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029177

P

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029177

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0202

C

Seeded From UniProt

complete

enables

GO:0005125

cytokine activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0202

F

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0051

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Karpala, AJ et al. (2008) Molecular cloning, expression, and characterization of chicken IFN -lambda. J. Interferon Cytokine Res. 28 341-50 PubMed GONUTS page
  2. 2.0 2.1 Reuter, A et al. (2014) Antiviral activity of lambda interferon in chickens. J. Virol. 88 2835-43 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page