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CHICK:B2L226

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) IFN-lambda
Protein Name(s) Interferon lambda

Interleukin 28

External Links
UniProt B2L226
EMBL EF587763
EU399904
KF680102
RefSeq NP_001121968.1
UniGene Gga.47678
STRING 9031.ENSGALP00000006033
GeneID 770778
KEGG gga:770778
CTD 770778
eggNOG NOG40189
HOGENOM HOG000232074
HOVERGEN HBG052108
KO K05447
NextBio 20920992
InterPro IPR029177
Pfam PF15177

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:2000379

positive regulation of reactive oxygen species metabolic process

PMID:18593329[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

PMID:18593329[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045918

negative regulation of cytolysis

PMID:18593329[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

NOT|involved_in

GO:0034141

positive regulation of toll-like receptor 3 signaling pathway

PMID:18593329[1]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

PMID:24371053[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045071

negative regulation of viral genome replication

PMID:24371053[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:3647279
PANTHER:PTN001277107
UniProtKB:B4ER10
UniProtKB:K9M1U5
UniProtKB:Q8IU54

P

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2450574
PANTHER:PTN001277107

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2450574
PANTHER:PTN001277107
UniProtKB:K9M1U5

C

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001277107
UniProtKB:Q8IU54

F

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

enables

GO:0005125

cytokine activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029177

F

Seeded From UniProt

complete

involved_in

GO:0007259

receptor signaling pathway via JAK-STAT

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029177

P

Seeded From UniProt

complete

involved_in

GO:0050778

positive regulation of immune response

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029177

P

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029177

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0202

C

Seeded From UniProt

complete

enables

GO:0005125

cytokine activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0202

F

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0051

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Karpala, AJ et al. (2008) Molecular cloning, expression, and characterization of chicken IFN -lambda. J. Interferon Cytokine Res. 28 341-50 PubMed GONUTS page
  2. 2.0 2.1 Reuter, A et al. (2014) Antiviral activity of lambda interferon in chickens. J. Virol. 88 2835-43 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page