CHICK:AVR2A

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	ACVR2A
Protein Name(s)	Activin receptor type-2A Activin receptor type IIA ACTR-IIA ACTRIIA
External Links
UniProt	Q90669
EMBL	D31899 U31222
PIR	S23089
RefSeq	NP_990698.1
UniGene	Gga.2852
ProteinModelPortal	Q90669
SMR	Q90669
STRING	9031.ENSGALP00000020317
PaxDb	Q90669
Ensembl	ENSGALT00000037806
GeneID	396324
KEGG	gga:396324
CTD	92
eggNOG	COG0515
GeneTree	ENSGT00760000118876
HOGENOM	HOG000231495
HOVERGEN	HBG054502
InParanoid	Q90669
KO	K04670
OMA	SCYGDKD
PhylomeDB	Q90669
TreeFam	TF352876
Reactome	REACT_289030 REACT_310846 REACT_314342 REACT_326856
NextBio	20816372
PRO	PR:Q90669
Proteomes	UP000000539
ExpressionAtlas	Q90669
GO	GO:0009986 GO:0005737 GO:0034673 GO:0016021 GO:0043235 GO:0017002 GO:0005524 GO:0015026 GO:0046872 GO:0004702 GO:0009952 GO:0030509 GO:0071773 GO:0007368 GO:0048706 GO:0001702 GO:0007498 GO:0043084 GO:0032927 GO:0030501 GO:0045648 GO:0045669 GO:0010862 GO:0030510 GO:0050999 GO:0060011 GO:0042713 GO:0007283
InterPro	IPR011009 IPR000719 IPR008271 IPR000472 IPR000333
PANTHER	PTHR23255
Pfam	PF01064 PF00069
PRINTS	PR00653
SUPFAM	SSF56112
PROSITE	PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0009798	axis specification	PMID:7589799^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0048185	activin binding	PMID:7589799^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:20071511^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0002295) part_of:(CL:0000202)\|part_of:(UBERON:0002295) part_of:(CL:0005014)	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:20071511^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0002295) part_of:(CL:0000202)\|part_of:(UBERON:0002295) part_of:(CL:0005014)	Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	PMID:20071511^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	acts_on_population_of:(CL:0005014)	Seeded From UniProt	complete
involved_in	GO:0032924	activin receptor signaling pathway	PMID:20071511^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048333	mesodermal cell differentiation	PMID:7589799^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	results_in_formation_of:(UBERON:0001135)\|results_in_formation_of:(UBERON:0001134)\|results_in_formation_of:(UBERON:0001133)\|results_in_formation_of:(UBERON:0002328)\|results_in_formation_of:(UBERON:0003062)	Seeded From UniProt	complete
enables	GO:0048185	activin binding	PMID:7589799^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0048185	activin binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102806 MGI:MGI:87912 PANTHER:PTN001147373 RGD:2028 RGD:70911 UniProtKB:A0A0B4KG59 UniProtKB:F1NCI7 UniProtKB:P27037 UniProtKB:Q90669 UniProtKB:Q90670	F		Seeded From UniProt	complete
enables	GO:0048185	activin binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102806 MGI:MGI:87912 PANTHER:PTN000583717 RGD:2028 RGD:70911 UniProtKB:F1NCI7 UniProtKB:P27037 UniProtKB:Q90669 UniProtKB:Q90670	F		Seeded From UniProt	complete
part_of	GO:0048179	activin receptor complex	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001147373 UniProtKB:A0A0B4KG59	C		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98728 MGI:MGI:98729 PANTHER:PTN000583675 RGD:621789 UniProtKB:O00238 UniProtKB:P36894 UniProtKB:P36896 UniProtKB:P36897 UniProtKB:P37023 UniProtKB:P37173 UniProtKB:Q04771	F		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000583675 UniProtKB:P27037 UniProtKB:P36896 UniProtKB:P36897 UniProtKB:P37173 UniProtKB:Q13705	C		Seeded From UniProt	complete
enables	GO:0034713	type I transforming growth factor beta receptor binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001147373 UniProtKB:P37173 UniProtKB:Q90999	F		Seeded From UniProt	complete
involved_in	GO:0032924	activin receptor signaling pathway	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001147373 UniProtKB:A0A0B4KG59 UniProtKB:F1NCI7 UniProtKB:P27037 UniProtKB:Q13705 UniProtKB:Q90669 UniProtKB:Q90670	P		Seeded From UniProt	complete
enables	GO:0019838	growth factor binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102806 MGI:MGI:87911 MGI:MGI:87912 PANTHER:PTN000583675 RGD:71082 UniProtKB:P36896 UniProtKB:P36897 UniProtKB:Q13705 UniProtKB:Q8NER5	F		Seeded From UniProt	complete
involved_in	GO:0007389	pattern specification process	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1338938 MGI:MGI:87912 PANTHER:PTN000583675	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003716 MGI:MGI:1338946 MGI:MGI:87911 MGI:MGI:98728 MGI:MGI:98729 PANTHER:PTN000583675 RGD:3852 RGD:620200 RGD:69651 RGD:70964 UniProtKB:A0A0B4KG59 UniProtKB:P36897 UniProtKB:P37023 UniProtKB:P37173 UniProtKB:Q04771 UniProtKB:Q06900 UniProtKB:Q90ZK6	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87911 PANTHER:PTN000583675 RGD:69651 RGD:70964 UniProtKB:P36896 UniProtKB:P37023 UniProtKB:Q04771 UniProtKB:Q13873	C		Seeded From UniProt	complete
enables	GO:0005026	transforming growth factor beta receptor activity, type II	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001147373 RGD:69651	F		Seeded From UniProt	complete
enables	GO:0005024	transforming growth factor beta-activated receptor activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98728 MGI:MGI:98729 PANTHER:PTN000583675 UniProtKB:A0A0B4KG59 UniProtKB:P36897 UniProtKB:P37023 UniProtKB:P37173 ZFIN:ZDB-GENE-070618-1	F		Seeded From UniProt	complete
enables	GO:0098821	BMP receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27038 ensembl:ENSMUSP00000067305	F		Seeded From UniProt	complete
involved_in	GO:0060011	Sertoli cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27038 ensembl:ENSMUSP00000067305	P		Seeded From UniProt	complete
involved_in	GO:0050999	regulation of nitric-oxide synthase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27038 ensembl:ENSMUSP00000067305	P		Seeded From UniProt	complete
involved_in	GO:0048706	embryonic skeletal system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27038 ensembl:ENSMUSP00000067305	P		Seeded From UniProt	complete
enables	GO:0048185	activin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27038 ensembl:ENSMUSP00000067305	F		Seeded From UniProt	complete
enables	GO:0043621	protein self-association	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27038 ensembl:ENSMUSP00000067305	F		Seeded From UniProt	complete
involved_in	GO:0043084	penile erection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27038 ensembl:ENSMUSP00000067305	P		Seeded From UniProt	complete
involved_in	GO:0042713	sperm ejaculation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27038 ensembl:ENSMUSP00000067305	P		Seeded From UniProt	complete
enables	GO:0034711	inhibin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27038 ensembl:ENSMUSP00000067305	F		Seeded From UniProt	complete
involved_in	GO:0030510	regulation of BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27038 ensembl:ENSMUSP00000067305	P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27038 ensembl:ENSMUSP00000067305	P		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27038 ensembl:ENSMUSP00000067305	F		Seeded From UniProt	complete
enables	GO:0019838	growth factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27038 ensembl:ENSMUSP00000067305	F		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27038 ensembl:ENSMUSP00000067305	C		Seeded From UniProt	complete
involved_in	GO:0009966	regulation of signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27038 ensembl:ENSMUSP00000067305	P		Seeded From UniProt	complete
involved_in	GO:0009952	anterior/posterior pattern specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27038 ensembl:ENSMUSP00000067305	P		Seeded From UniProt	complete
involved_in	GO:0008584	male gonad development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27038 ensembl:ENSMUSP00000067305	P		Seeded From UniProt	complete
involved_in	GO:0007498	mesoderm development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27038 ensembl:ENSMUSP00000067305	P		Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27038 ensembl:ENSMUSP00000067305	P		Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27038 ensembl:ENSMUSP00000067305	P		Seeded From UniProt	complete
involved_in	GO:0001702	gastrulation with mouth forming second	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27038 ensembl:ENSMUSP00000067305	P		Seeded From UniProt	complete
involved_in	GO:0071773	cellular response to BMP stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27037 ensembl:ENSP00000241416	P		Seeded From UniProt	complete
enables	GO:0048185	activin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27037 ensembl:ENSP00000241416	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27037 ensembl:ENSP00000241416	P		Seeded From UniProt	complete
involved_in	GO:0045669	positive regulation of osteoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27037 ensembl:ENSP00000241416	P		Seeded From UniProt	complete
involved_in	GO:0045648	positive regulation of erythrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27037 ensembl:ENSP00000241416	P		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27037 ensembl:ENSP00000241416	C		Seeded From UniProt	complete
part_of	GO:0034673	inhibin-betaglycan-ActRII complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27037 ensembl:ENSP00000241416	C		Seeded From UniProt	complete
involved_in	GO:0032927	positive regulation of activin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27037 ensembl:ENSP00000241416	P		Seeded From UniProt	complete
involved_in	GO:0032924	activin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27037 ensembl:ENSP00000241416	P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27037 ensembl:ENSP00000241416	P		Seeded From UniProt	complete
involved_in	GO:0030501	positive regulation of bone mineralization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27037 ensembl:ENSP00000241416	P		Seeded From UniProt	complete
enables	GO:0017002	activin-activated receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27037 ensembl:ENSP00000241416	F		Seeded From UniProt	complete
enables	GO:0015026	coreceptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27037 ensembl:ENSP00000241416	F		Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27037 ensembl:ENSP00000241416	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27037 ensembl:ENSP00000241416	C		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27037 ensembl:ENSP00000241416	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333 InterPro:IPR000472	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333 InterPro:IPR000719	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P		Seeded From UniProt	complete
involved_in	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333 InterPro:IPR000472	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Stern, CD et al. (1995) Activin and its receptors during gastrulation and the later phases of mesoderm development in the chick embryo. Dev. Biol. 172 192-205 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 McCullar, JS et al. (2010) Activin potentiates proliferation in mature avian auditory sensory epithelium. J. Neurosci. 30 478-90 PubMed GONUTS page
↑ ^3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:7589799-1] 1.0 ^1.1 ^1.2 ^1.3 Stern, CD et al. (1995) Activin and its receptors during gastrulation and the later phases of mesoderm development in the chick embryo. Dev. Biol. 172 192-205 PubMed GONUTS page

[PMID:20071511-2] 2.0 ^2.1 ^2.2 ^2.3 McCullar, JS et al. (2010) Activin potentiates proliferation in mature avian auditory sensory epithelium. J. Neurosci. 30 478-90 PubMed GONUTS page

[PMID:21873635-3] 3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CHICK:AVR2A

Contents

Annotations

Notes

References

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