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CHICK:AL1A2

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) ALDH1A2 (synonyms: RALDH2)
Protein Name(s) Retinal dehydrogenase 2

RALDH 2 RalDH2 Aldehyde dehydrogenase family 1 member A2 Retinaldehyde-specific dehydrogenase type 2 RALDH(II)

External Links
UniProt O93344
EMBL AF064253
AF181680
RefSeq NP_990326.1
UniGene Gga.2996
ProteinModelPortal O93344
SMR O93344
STRING 9031.ENSGALP00000033786
PaxDb O93344
Ensembl ENSGALT00000006791
GeneID 395844
KEGG gga:395844
CTD 8854
eggNOG COG1012
GeneTree ENSGT00760000118999
HOGENOM HOG000271505
HOVERGEN HBG000097
InParanoid O93344
KO K07249
OMA KAWKPGN
PhylomeDB O93344
Reactome REACT_278149
UniPathway UPA00912
NextBio 20815911
PRO PR:O93344
Proteomes UP000000539
ExpressionAtlas O93344
GO GO:0005737
GO:0004028
GO:0004029
GO:0001758
GO:0042572
Gene3D 3.40.309.10
3.40.605.10
InterPro IPR016161
IPR016163
IPR016160
IPR029510
IPR016162
IPR015590
Pfam PF00171
SUPFAM SSF53720
PROSITE PS00070
PS00687

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0003007

heart morphogenesis

PMID:10500184[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001947

heart looping

PMID:10500184[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:10500184[1]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0021522

spinal cord motor neuron differentiation

PMID:9727493[2]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004745

retinol dehydrogenase activity

PMID:9727493[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004029

aldehyde dehydrogenase (NAD) activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0012036
MGI:MGI:1861722
PANTHER:PTN000192421
RGD:2087
RGD:620252
RGD:68409
RGD:69219
SGD:S000000875
SGD:S000005901
UniProtKB:O75891
UniProtKB:P00352
UniProtKB:P05091
UniProtKB:P08157
UniProtKB:P48644
UniProtKB:P49189
UniProtKB:Q3SY69

F

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR015590
InterPro:IPR016160
InterPro:IPR016161
InterPro:IPR016162
InterPro:IPR016163
InterPro:IPR029510

F

Seeded From UniProt

complete

enables

GO:0016620

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016163

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR015590
InterPro:IPR016160
InterPro:IPR016161
InterPro:IPR016162
InterPro:IPR016163
InterPro:IPR029510

P

Seeded From UniProt

complete

enables

GO:0001758

retinal dehydrogenase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.2.1.36

F

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

involved_in

GO:0042572

retinol metabolic process

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00912

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Tsukui, T et al. (1999) Multiple left-right asymmetry defects in Shh(-/-) mutant mice unveil a convergence of the shh and retinoic acid pathways in the control of Lefty-1. Proc. Natl. Acad. Sci. U.S.A. 96 11376-81 PubMed GONUTS page
  2. 2.0 2.1 Sockanathan, S & Jessell, TM (1998) Motor neuron-derived retinoid signaling specifies the subtype identity of spinal motor neurons. Cell 94 503-14 PubMed GONUTS page
  3. Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page