CHICK:ACM2

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	CHRM2 (synonyms: CM2)
Protein Name(s)	Muscarinic acetylcholine receptor M2
External Links
UniProt	P30372
EMBL	M73217
PIR	A40972
RefSeq	NP_001025936.1
UniGene	Gga.10240 Gga.49677
ProteinModelPortal	P30372
STRING	9031.ENSGALP00000020999
PaxDb	P30372
Ensembl	ENSGALT00000021029
GeneID	418126
KEGG	gga:418126
CTD	1129
eggNOG	NOG250863
GeneTree	ENSGT00780000121874
HOGENOM	HOG000231484
HOVERGEN	HBG105720
InParanoid	P30372
KO	K04130
OMA	TIEVVFI
OrthoDB	EOG7V49Z7
PhylomeDB	P30372
TreeFam	TF320495
Reactome	REACT_338065 REACT_354470
NextBio	20821333
PRO	PR:P30372
Proteomes	UP000000539
GO	GO:0030054 GO:0005829 GO:0005887 GO:0045211 GO:0045202 GO:0016907 GO:0007197 GO:0007213 GO:0007207 GO:0051482 GO:0008016 GO:0006940 GO:0009615 GO:0007606 GO:0007271
InterPro	IPR000276 IPR017452 IPR001065 IPR000995
PANTHER	PTHR24249:SF57
Pfam	PF00001
PRINTS	PR00237 PR00243 PR00539
PROSITE	PS00237 PS50262

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08172	C	Seeded From UniProt	complete
enables	GO:0016907	G protein-coupled acetylcholine receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08172	F	Seeded From UniProt	complete
involved_in	GO:0007213	G protein-coupled acetylcholine receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08172	P	Seeded From UniProt	complete
enables	GO:0030594	neurotransmitter receptor activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000664111 RGD:71034	F	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000664111 RGD:2342 RGD:2343 RGD:2518 RGD:2522 RGD:2851 RGD:61800 RGD:61801 RGD:620023 RGD:62044 RGD:71034	C	Seeded From UniProt	complete
enables	GO:0016907	G protein-coupled acetylcholine receptor activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000037 MGI:MGI:88397 MGI:MGI:88399 PANTHER:PTN001207082 RGD:2342 RGD:2343 RGD:620023 RGD:620027 UniProtKB:P08172 WB:WBGene00001519	F	Seeded From UniProt	complete
involved_in	GO:0007268	chemical synaptic transmission	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000664111 RGD:2830 RGD:2846	P	Seeded From UniProt	complete
involved_in	GO:0007197	adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88399 PANTHER:PTN001207082	P	Seeded From UniProt	complete
involved_in	GO:0007187	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000664111 RGD:2851 RGD:62044	P	Seeded From UniProt	complete
involved_in	GO:0006940	regulation of smooth muscle contraction	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000665559 RGD:620023	P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000037 PANTHER:PTN000664111 RGD:2343 UniProtKB:P08172 UniProtKB:P08908 UniProtKB:P21917 UniProtKB:P28221 UniProtKB:P28222 UniProtKB:P28335 UniProtKB:P28566 UniProtKB:P30546 UniProtKB:P30939 WB:WBGene00001519	C	Seeded From UniProt	complete
enables	GO:0004993	G protein-coupled serotonin receptor activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004168 FB:FBgn0004573 FB:FBgn0087012 FB:FBgn0263116 MGI:MGI:109323 MGI:MGI:96273 MGI:MGI:96274 MGI:MGI:96276 MGI:MGI:96281 MGI:MGI:96284 PANTHER:PTN000664111 RGD:2845 RGD:2846 RGD:2848 RGD:2850 RGD:2851 RGD:61800 RGD:62044 RGD:62388 RGD:71034 UniProtKB:A0A0B4KFU6 UniProtKB:P08908 UniProtKB:P28221 UniProtKB:P28222 UniProtKB:P28223 UniProtKB:P28335 UniProtKB:P28566 UniProtKB:P30939 UniProtKB:P41595 UniProtKB:P47898 UniProtKB:Q13639 WB:WBGene00004776 WB:WBGene00004779	F	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000664111 RGD:2518	F	Seeded From UniProt	complete
involved_in	GO:0098664	G protein-coupled serotonin receptor signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004993	P	Seeded From UniProt	complete
enables	GO:1990763	arrestin family protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08172 ensembl:ENSP00000399745	F	Seeded From UniProt	complete
enables	GO:0016907	G protein-coupled acetylcholine receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08172 ensembl:ENSP00000399745	F	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08172 ensembl:ENSP00000399745	C	Seeded From UniProt	complete
involved_in	GO:0009615	response to virus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08172 ensembl:ENSP00000399745	P	Seeded From UniProt	complete
involved_in	GO:0007213	G protein-coupled acetylcholine receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08172 ensembl:ENSP00000399745	P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08172 ensembl:ENSP00000399745	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08172 ensembl:ENSP00000399745	C	Seeded From UniProt	complete
involved_in	GO:2000300	regulation of synaptic vesicle exocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ4 ensembl:ENSMUSP00000130874	P	Seeded From UniProt	complete
part_of	GO:0098981	cholinergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ4 ensembl:ENSMUSP00000130874	C	Seeded From UniProt	complete
enables	GO:0016907	G protein-coupled acetylcholine receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ4 ensembl:ENSMUSP00000130874	F	Seeded From UniProt	complete
involved_in	GO:0007213	G protein-coupled acetylcholine receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ERZ4 ensembl:ENSMUSP00000130874	P	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276	F	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000995	C	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR000995 InterPro:IPR001065	P	Seeded From UniProt	complete
involved_in	GO:0008016	regulation of heart contraction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001065	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR001065 InterPro:IPR017452	C	Seeded From UniProt	complete
enables	GO:0016907	G protein-coupled acetylcholine receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000995 InterPro:IPR001065	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770	C	Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0628 UniProtKB-SubCell:SL-0219	C	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P	Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CHICK:ACM2

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